Clinical Trials

The purpose of this study is to investigate the extent to which advanced MRI measurements can help predict brain signals measured with intracranial electrodes.

The purpose of this study is to set up the infrastructure for future clinical trials for patients with cavernous malformations. To do this we will be assessing the quality of MRI and data collection from patients with cavernous malformations across multiple sites in the country. At Mayo, we will be looking at new MRI "sequences" in addition to the usual sequences to see if that helps determine which cavernous malformations may bleed again.

This proposal includes evaluation of brain iron quantification method using MR imaging and will operate within the NSR guidelines for data acquisition established by the FDA/CDRH. The significant testing by vendor and Mayo staff prior to in vivo use, assure the safety of these studies and overall system stability. 

The result of these studies will be used to validate new technology to determine the iron level in the brain and correlate the iron deposit with age, gender, and pathology.

The purpose of this study is to better understand the mechanisms by which people retain control of their bowel contents and evacuate stool (defecation) and why people have constipation or fecal incontinence (involuntary stool leakage). Pressure measurements (by manometry) and magnetic resonance imaging (MRI) are widely used for diagnosis in patients with constipation or fecal incontinence. This study is trying to improve the utility of these tests for diagnosing these problems and to understand if pressure measurements (by manometry) can be related to strength of the anal sphincter measured by MRI. To do this, we will study the effects of alfuzosin on these muscles.

The purpose of this study is to evaluate the detection rates of MRI-targeted prostate biopsies compared to standard 12-core trans-rectal ultrasound guided (TRUS) prostate biopsies for prostate cancer. 

The purpose of this study is to develop and test a wide range of software, all designed to operate an MRI scanner more efficiently - to produce higher quality images, with less undesired variability, in a shorter exam time and with a better patient experience.
 

The purpose of this study is to evaluate the performance of the new compact Magnetic Resonance Imaging (MRI) scanner compared to standard MR exams of the brain.

The primary purpose of this study is to describe the utilization and findings on magnetic resonance imaging (MRI) of the hands and feet in patients with seronegative rheumatoid arthritis (RA) (based on the ACR 1987 or 2010 classification criteria) compared to the findings seen in patients with seropositive disease (RF or ACPA positive).

The primary purpose of this study is to determine the serum and urine gadolinium reference ranges in patients with normal renal function being administered Gadobutrol for an enhanced MRI exam.

This is a subaward with Washington University in St. Louis (Wash U) as the prime site. This study is designed to assess the efficacy of drug treatment to pre-AD subject. Dr. Jack's ADIR lab will have no patient contact and will only receive de-identified data from Wash U. ADIR will assess the images for MRI protocol compliance and quality. Neuroradiologists in the lab will provide safety assessments and provide inclusion/exclusion recommendations. Mayo Clinic in Rochester will also be a safety MRI site for local participants who are enrolled at other performance sites. Research ...

The purpose of this research is to better understand brain white matter hyperintensities (WMH) in women with migraine. We will accomplish this by comparing brain imaging and clinical assessments of women with migraine, small vessel ischemic (SVI) disease, and multiple sclerosis (MS).

The objective of this study is to investigate the clinical utility of the mi-eye 2™ device. This will be done by measuring the frequency with which the MRI and mi-eye 2™, respectively, change the Investigator’s primary diagnosis, confidence in diagnosis and management plan, in a routine clinical setting.

The purpose of this study is to assess advanced imaging methods for the prostate and pelvis. Specifically, we are studying methods that allow us to acquire higher resolution images of the prostate and pelvis more quickly than our current imaging methods. These types of fast high resolution MRI acquisitions have been shown in the literature to improve cancer detection.

The purpose of this study is to test computer software for removing face data from medical images. This study will help us determine whether the software can remove face data without hurting the medical and research use of these images.

The purpose of this study is to better understand specific MRI characteristics of different pediatric disorders affecting the brain using new MRI analysis and imaging techniques to detect and understand subtle changes in specific parts of the brain.

In the past data has indicated that Gadolinium based contrast may specify brain tissue intensity in subsequent MRI exams. This study is being conducted to try and determine normal ranges of specific tissue ratios for old and new 1.5 and 3T systems. We are hoping that this study allows us to develop a normal range intensity/ratio profiles for specific tissue regions of interest in the brain.

The purpose of this study is to investigate if blood and/or MRI markers of inflammation and immune system activation may show changes in relation to when you have a seizure, and to noninvasively detect seizure related structural and functional alterations in acute seizure by MRI.

The purpose of this study is to evaluate the performance of a compact, 3T magnetic resonance (MR) scanner for patients with MR conditional implanted devices, including MR conditional spinal cord stimulators.

The ischiofemoral space (IFS) has been evaluated with radiographs, CT, and magnetic resonance imaging (MRI). Recent studies have questioned the reliability of IFS measurements taken without controlling hip position. In recent years the utilization of outpatient musculoskeletal ultrasonography (MSK US) increased has increases dramtically. MSK US offers many benefits to a musculoskeletal practice, including rapid diagnosis of disorders of bones, joints, tendons, muscles, ligaments, blood vessels, and nerves, as well as the ability to guide interventions to treat these structures. The primary aim of this study is to evaluate the inter-rater and intra-rater reliability of US measurements of the IFS.  A secondary aim is ...

This study uses an MRI scan called an MR Spectroscopy to measure brain chemicals before and after treatment with lamotrigine or fluoxetine in patients with bipolar depression. This better understanding of therapy impact on brain function may help individualize future treatment for bipolar depression.

The purpose of this study is to utilize neuroimaging to assess the neurobiological mechanisms underlying disease progression in progressive apraxia of speech.
 

The objective of this proposal is to evaluate MRI hardware and software features that have potential to improve the interventional MRI (iMRI) practice.

The goal of this study is to evaluate and optimize our existing phosphorus MRI head coil and imaging sequence on healthy human volunteers. 

The purpose of this study is to assess if it is possible to use a carotid MRI/MRA to see if cholesterol lowering medication is causing a reduction in the amount of plaque in the arteries.

The purpose of this study is to learn whether Cardiac Magnetic Resonance Imaging (cMRI) and/or echocardiogram is useful to diagnose patients with unique heart conditions. This research study focuses on evaluating the use of cMRI or echocardiogram as a novel, non-invasive method for evaluating specific heart conditions.

The purpose of this research study is to improve the quality of Magnetic Resonance Imaging (MRI) examinations.

The purpose of this study is to evaluate whether newly developed acquisition techniques or 1.5 Tesla and 3.0 Tesla MRI scanners systems can provide improvements over current acquisition techniques. The objective of this protocol is to allow investigators to perform initial test evaluation in humans of new MRI acquisition techniques.  

All pulse sequences, including the ones that we testing, can be used on FDA-approved MRI scanners as long as they meet FDA guidelines for non-significant risk, and our new sequences all meet these guidelines.

All MRI test scans of new pulse sequences will be performed subject to FDA guidelines ...

The purpose of this study is to establish normal Magnetic Resonance quantitative values (tissues stiffness, Apparent Diffusion Coefficient values and Blood Oxygen Level Determination values for both renal cortex and medullary tissues and total renal blood flow) for young Autosomal Dominant Polycystic Kidney Disease patients with normal renal function, and normal young adult controls without Autosomal Dominant Polycystic Kidney Disease and normal renal function.

Hypothesis: Newer Magnetic Resonance quantitative imaging parameters (tissue stiffness, Apparent Diffusion Coefficient, Blood Oxygen Level Determination levels, Magnetization Transfer and renal blood flow) will have different values in young adult ADPKD patients as compared to normal volunteers.

This study will evaluate the bio-mechanical and biochemical abnormalities in acute ACL-injured knees over time. Data will be collected through advanced quantitative MR imaging, functional testing, and bio-specimen collection. Researchers will collect this data from the time of baseline visit, which is within 28 days of injury, through the temporal sequence of post-operative or post-injury recovery and return to activity.

The hypotheses for this study are (1) that T1ρ and T2 will be significantly elevated in the lateral side of ACL-injured knees immediately after injury (indicating damage caused by initial injury), and will not fully recover at 6-month, 1-year ...

The purpose of this study is to look at imaging characteristics of carotid plaques in symptomatic versus asymptomatic patients. Patients will undergo carotid plaque imaging with MRI and findings will be correlated with patient symptomatic status.

This research study is being done to look at a new MRI imaging software, Siemens Interventional Software, to see if we can improve our ability to see and treat cancerous tumors.

The purpose of the study is to quantify gadolinium levels in the serum and urine of local and nonlocal patients.

This study will determine if a multiband EPI fMRI pulse sequence provides higher quality data than a traditional EPI fMRI pulse sequence for language fMRI. 
 

The purpose of this study is to determine if stress cardiac magnetic resonance imaging (MRI) imaging will allow us to detect radiation-related cardiac toxicity before other evaluation modalities would allow.

This study will use powerful 7T MRI scanning to find very small brain lesions that cause partial epileptic seizures.These small lesions can be missed by current MRI scanners. When a  neurosurgeon can find and remove the small area where the seizure starts, it is often possible to cure the epilepsy.

The purpose of this study is to develop quantitative approaches of analyzing multimodal MRI acquisitions with the goal to improve cortical lesion detection in all stages in MS, and to understand the interplay between cortical lesions, white matter lesions and functional connectivity network disruptions.

The purpose of this study is to continue the evaluation of non-FDA approved MR equipment software and hardware for imaging the heart and associated vasculature.

The purpose of this research study is to gather information on the safety and effectiveness of new MRI Non-FDA approved software. The evaluation of the new MRI software methods will provide the radiologist with more tools to assist him/her in making an accurate diagnosis of your specific condition.

Zero echo time (ZTE) is seen as a viable radiation-free alternative to a CT scan. This study will investigate this opportunity by developing clinical workflows, comparing ZTE and CT images, and determining costs.

The purpose of this study is to compare the fast and conventional MRI exams in the same patient who will subsequently undergo knee arthroscopy; arthroscopy represents the “gold standard” information.

This study will study of the effectiveness of Blackbone MRI in a pediatric population.

The overall purpose of this study is to evaluate the safety and diagnostic effectiveness of Mangoral in liver MRI in patients with known or suspected focal liver lesions and severe renal impairment. The diagnostic efficacy of Mangoral will be assessed in terms of visualization of detected focal liver lesions in combined MRI (CMRI: combined Mangoral-enhanced and unenhanced MRI) compared to unenhanced MRI.

The purpose of this study is to improve magnetic resonance (MR) evaluation for middle ear cholesteatoma at 3T (investigational protocol).

The purpose of this study is to evaluate magnetic resonance imaging (MRI) as a non-invasive imaging method to detect chronic pancreatitis (CP) and quantify pancreatic fibrosis.

The primary objective of this application is to establish the feasibility of widespread clinical use of advanced MRS technology for early AD diagnosis in a strategic alliance between MR physicists at the UMN and physician scientists at Mayo Clinic.

The aim of this study is to develop machine-learning algorithms and infrastructure through the analysis of MR image data for training and testing, for the detection of intravenous infiltration of MR contrast agent. This aim will be achieved through the analysis of both non-infiltrated and infiltrated brain MR images.  This analysis will involve segmenting and analyzing the nasal mucosa region following contrast agent administration. The developed machine learning model will be trained to be able to differentiate between non-infiltrated (contrast-enhanced) and infiltrated MR images and thus determine if infiltration has occurred.  The training and testing data will include ...

The long-term goal of this research program is to clarify the potential mutation causing and cancer causing risk posed by clinical magnetic resonance imaging (MRI).

The purpose of this study is to develop an MRI based model to accurately identify persistent posttraumatic headache related to mild traumatic brain injury, as different from chronic migraine.

The purpose of this study is to test multiple positions of the passive driver (vibration transmitter) on the patient in Cardiac Magnetic Resonance Elastography (MRE) to find the best position for scanner imaging.

The purpose of this study is to identify the area patterns of deposits in the brains of subjects who have a prior history of gadolinium contrast exposure. These results will be compared against those from a similar study on subjects with no history of gadolinium exposure.  

The purpose of this study is a comprehensive review of the clinical and radiologic history in these patients as well as review of neuropathology in deceased patients, where available.  The goal of this research is to investigate the hypothesis that this presentation represents a spatially limited form of CNS inflammatory demyelinating disease.

The natural course of autosomal dominant polycystic kidney disease (ADPKD) is highly variable and typically characterized by progressive enlargement of cysts within the kidneys.  ADPKD is a leading cause of end-stage renal disease.  Recently, a new medication called Tolvaptan has been approved by the FDA to slow progression of ADPKD.  Accurate, MR based kidney volume measurements are the best parameter for following the progression of ADPKD, and are suggested be acquired to measure progression and effects of Tolvaptan.  However, making these slice-by-slice volume measurements can be extremely time consuming when done manually.  The purpose of this work is to evaluate an AI algorithm to make the ...

The purpose of this study is to evaluate PD-0325901 in the treatment of symptomatic inoperable neurofibromatosis type-1 (NF1)-associated plexiform neurofibromas (PNs). All participants will receive PD-0325901.

The aim of this study is to develop machine-learning algorithms and infrastructure through the analysis of MR image data for training and testing, for the detection of intravenous infiltration of MR contrast agent. This aim will be achieved through the analysis of both non-infiltrated and infiltrated brain MR images.  This analysis will involve segmenting and analyzing the nasal mucosa region following contrast agent administration. The developed machine learning model will be trained to be able to differentiate between non-infiltrated (contrast-enhanced) and infiltrated MR images and thus determine if infiltration has occurred.  The training and testing data will include ...

The long-term goal of this research program is to clarify the potential mutation causing and cancer causing risk posed by clinical magnetic resonance imaging (MRI).

The purpose of this study is to develop an MRI based model to accurately identify persistent posttraumatic headache related to mild traumatic brain injury, as different from chronic migraine.

The purpose of this study is to test multiple positions of the passive driver (vibration transmitter) on the patient in Cardiac Magnetic Resonance Elastography (MRE) to find the best position for scanner imaging.

The purpose of this study is to identify the area patterns of deposits in the brains of subjects who have a prior history of gadolinium contrast exposure. These results will be compared against those from a similar study on subjects with no history of gadolinium exposure.  

This research study is being done to look at new MRI imaging guidance software, Philips Interventional iSuite software, to see if using will improve the physician's ability to quickly place and guide needle tip position for biopsies and ablations.

The purpose of this study is to see if magnetic resonance imaging (MRI) can determine the cause of these lung nodules.

The primary objective of this project is to compare metrics of CSF through the cerebral aqueduct among imaging platforms to determine the variability in results.

The purpose of this study is to explain the mechanisms of impaired rectal evacuation characterizing phenotypes in functional defecation disorders, and ascertain if pelvic floor retraining can be tailored to underlying mechanisms.

The purpose of this study is to evaluate new MRI Non-FDA approved software methods and to provide the radiologist with more tools to assist his/her in making an accurate diagnosis of a specific condition.

The purpose of this study is to evaluate whether or not an MRI technique (quantitiative magnetization transfer or qMT) in narrowing human kidneys is feasible, reproducible, and predicts recovery.

The purpose of this study is to evaluate if pulsed arterial spin labeling magnetic resonance imaging (PASL MRI) is able to measure a difference in hypothalamic blood flow in patients with anorexia nervosa, opposite than obesity when compared to health.

The purpose of this study is evaluate changes in male and female athletes’ brains following concussion injury and recovery, and to see whether female athletes demonstrate a different pattern of recovery compared to male athletes.

The purpose of this study is to compare the clinical application of two emerging magnetic resonance (MR) imaging modalities which Mayo Clinic has the technical capability of using, by adding them at the same time that standard imaging is done for patients receiving treatment for Ewing Sarcoma , Rhabdomyosarcoma and soft tissue sarcoma.  

The overall purpose is to study how a variety of technological approaches in Magnetic resonance imaging (MRI) can be used to provide improved performance non-contrast MR imaging as used for angiography and perfusion.  These include but are not limited to improvements in: (i) receiver coils; (ii) pulse sequences for data acquisition; (iii) methods for image reconstruction; (iv) algorithms for deriving MRI-based quantitative parameters and biomarkers.

The purpose of this study is to validate an NMR-based (Nuclear magnetic resonance) serum metabolite constellation for detection of early Hepatocellular carcinoma (HCC) lesions in liver cirrhosis.

Can an MRI detect and monitor the inflammatory and fibrotic possess in patients with Eosinophilic Esophagitis

The purpose of this study is to evaluate and develop new imaging techniques on the new MRI scanner.

The primary purpose of this study is to compare the diagnostic utility of 7T MRI versus 3T MRI in the detection of subtle epileptogenic lesions in the brain.

The purpose of this study is to evaluate the diagnostic benefit of adding exercise to cardiac Magnetic Resonance Imaging to help show early changes that may assist in the earlier diagnosis of Pulmonary Artery Hypertension.

The purpose of this study is to compare the sensitivity and specificity of ultra-high field MRI (7 Tesla) to standard 3T MRI for the of characteristic imaging findings in the diagnosis of Adult-onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP).

This study is investigating the usefulness of using functional magnetic resonance imaging (fMRI) to monitor brain activation during deep brain stimulation for Parkinson's Disease. The study may determine the relationship between patterns of brain activation and therapeutic outcome and/or side effects.

The purpose of this study is to assess cardiac dyspnea using exercise cardiac magnetic resonance as a diagnostic tool.

The purpose of this study is to determine the usefulness of combining PET scan activity and MRI image biomarkers for the clinical management of spinal joint low back pain.

The purpose of this study is to study the brain response to different wavelengths of light. 

The purpose of this study is to create a standardized cardiac MRI imaging protocol for patients with Congenital Heart Disease. 

The objectives of this study are to identify the unique individual neuro-hormonal footprint of volumetric, caloric, and hedonic stimulation along the distinct stages of food intake regulation, to categorize the hormone(s) and brain area(s) that predominate in each stage of food intake regulation, and to discover the unique neuro-hormonal footprint which may predict subsequent caloric intake.

The purpose of this study is to measure the part-worth utilities breast MRI screening patients place on different MRI gadolinium contrast parameters, and to use those data to better understand and deliver patient-centered contrast agents for MRI screening exams.

The purpose of this study is to compare the effectiveness of 7T imaging to the current conventional imaging (3T) to improve MR sensitivity to the changes of multiple sclerosis.  Using FDA-cleared 7T imaging would have a substantial impact on patient management.

The purpose of this study is to prospectively determine if magnetic resonance imaging (MRI) in patients with cardiac implantable electronic devices (CIED) results in myocardial injury as assessed by changes in high sensitivity cardiac troponin T (hs-cTnT) assay. This will be done by comparing pre-and-post MRI hs-cTnT levels in these patients.

The dual purposes of this study are to determine whether the increased performance of the Compact 3T scanner produces higher quality data than a traditional 3T and a 7T scanner using three of the most commonly employed tasks in current clinical practice, and to determine which of these three scanner platforms provides the highest quality resting state fMRI data primarily assessing the default mode network.

The objective of this study is to compare the central neural circuitry with fMRI (7T) in 30 asymptomatic healthy controls, 30 constipated patients without DD, and 30 constipated patients with DD at rest (functional connectivity analysis), during rectal distention to desire to defecate and urgency, and during evacuation. 

The purpose of this study is to improve patient care by optimizing and measuring magnetic resonance imaging methods for the early detection of brain cancer response to therapy.

A combined molecular breast imaging / ultrasound system will enable coregistration of a functional abnormality seen on Molecular Breast Imaging (MBI) with the corresponding anatomical abnormality seen on ultrasound.

The purpose of this study is to evaluate the effectiveness of ultrasound reduction imaging for liver steatosis grading using Proton Density Fat Fraction (PDFF) measured by magnetic resonance imaging (MRI) as the reference standard.

The purpose of this study is to compare the effectiveness of ultrasound with magnetic resonance (MR) enterography in the diagnosing and monitoring of Crohn's disease.

The purpose of this study is to evaluate whether ultrasound can detect medial meniscal extrusion more frequently than MRI.

The purpose of this study is to compare the accuracy of ultrasound to MRI for the diagnosis and characterization of tears in the ulnar collateral ligament (UCL) of the thumb.

This clinical trial compares the use of quantitative transmission imaging (QTI) to standard of care MRI as a supplemental screening tool for patients with a high lifetime risk of breast cancer. QTI is a single 3D ultrasound test intended to be used as an initial evaluation method for asymptomatic women identified with above-average risk for developing breast cancer. Using QTI may be an effective supplemental screening tool, compared to MRI for patients with a high lifetime risk of breast cancer.

The purpose of this study is to develop and test software that may improve MRI imaging by shortening the exam time.

The purpose of this study is to demonstrate that ZTE allows for better visualization of bone cement breast biopsy markers when compared to conventional breast biopsy markers and pulse sequences.

The purpose of this study is to determine whether cardiac magnetic resonance elastography (MRE) can detect acute myocardial infarctions in humans as areas of increased stiffness, and to compare cardiac MRE stiffness to microvascular obstruction in acute myocardial infarction.  

The purpose of this study is to find out if a PET/MR scan in combination with standard MRI and CT scans can improve the early detection and treatment of patients with prostate cancer.

The purpose of this study is to provide normal reference values for cardiac magnetic resonance elastography.

The purpose of this study is to evaluate the ability of PET/MRI (Positron Emission Tomography/Magnetic Resonance Imaging) to give physicians preoperative information about specific sites in the body that the endometrial cancer may be present. If the PET/MRI is accurate and successful in providing this information, then women in the future may be able to have less extensive surgery for their endometrial cancer after evaluation with PET/MRI.

The purpose of this study is to use functional imaging to study the mechanisms of the anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS).

This research study is being done because we want to better understand the composition of exhaled breath and exhaled breath condensate in health and disease and at different stages of disease to determine if there are markers in this easy to collect sample that can help us understand disease progression and give earlier warning that health or disease status is declining and improve treatment for patients.

This research study is being done because we want to better understand the composition of exhaled breath and exhaled breath condensate in health and disease and at different stages of disease to determine if there are markers in this easy to collect sample that can help us understand disease progression and give earlier warning that health or disease status is declining and improve treatment for patients.

The purposes of this study are to assess image quality of a multiparametric MRI protocol for local staging imaging among patients with bladder cancer, and to assess accuracy of MR imaging in determining muscle invasion.

The purpose of this study is to determine if a single ZTE MR sequence can replace the need for a CT of the pelvis to avoid an additional exam and avoid the radiation to these patients from CT.

The purpose of this study is to describe the changes in cardiac Magnetic Resonance Elastography stiffness in Hypertrophic cardiomyopathy patients pre- and post-myectomy.

This prospective clinical trial (PRostate Imaging using Mri +/- contrast Enhancement (PRIME)) aims to assess whether biparametric MRI (bpMRI) is non-inferior to multiparametric mpMRI (mpMRI) in the detection of clinically significant prostate cancer.

The primary purpose of this study is to evaluate the feasibility and safety of MRI-guided focal laser ablation (Laser-Induced Interstitial Thermal Therapy, LITT) to treat low-risk native prostate cancer.

The purpose of this research is to use advanced 3D kidney MRE imaging for detecting or characterizing hepatorenal syndrome processes, providing capabilities unavailable with other imaging techniques or serum biomarkers.

The purpose of this study is to determine if neurodevelopmental abnormalities in children exposed to anesthesia prior to age 3 are associated with specific changes in brain MRI.  Individuals who have already undergone detailed neuropsychological testing as part of an earlier study will be invited to return for brain imaging.

The purpose of this study is to examine the capability of contrast enhanced breast PCD-CT in staging breast cancer within the breasts and regional nodes of human subjects. Developing and using a PCD-CT imaging technique and postprocessing algorithms, dedicated for breast cancer detection.

The purpose of this study is to develop an MRS-based measurement of 2-HG that is reliable, and to assess the reproducibility of the method(s) above on a cohort of patients with IDH mutant low grade gliomas.  

The purpose of this study is to validate an MRI method to detect renal fibrosis in patients after kidney transplantation (KT).

The purpose of this study is to determine if there are changes in mild traumatic brain injury (mTBI) and/or repetitive head impacts (RHI) detectible with multiparametric MR Elastography (MRE). The hypothesis is that multiparametric MR Elastography will detect changes in the mechanical properties of human head tissues in patients following head traumas.

The purpose of this study is to develop Magnetic Resonance Elastography (MRE) techniques and protocol for brain applications on 7T MRI scanners.

The purpose of this study is to develop a functional MRI memory task for clinical presurgical mapping.

The purpose of this study is to evaluate the safety and ablation efficacy of the ExAblate UF V2 System when treating symptomatic uterine fibroids. The ExAblate System is a medical device that involves a focused ultrasound system and an MRI scanner. ExAblate delivers a pulse of focused ultrasound energy, or sonication, to the targeted tissue. In this particular study, the targeted tissue is uterine fibroids. Each sonication is used to heat small spots in the fibroid much like a magnifying glass can be used to focus light to heat a spot. The heat created kills a portion of the fibroid ...

Mayo Clinic is developing and testing the effectiveness of an investigational imaging technique called magnetic resonance elastography (MRE). This technique measures the stiffness (mechanical properties) of tissues.

The purpose of this study is to demonstrate the use of 3D ZTE imaging of the cervical spine to assess osseous neural foraminal stenosis and directly compare it to CT. Other objectives will include evaluation of ossification of the posterior longitudinal ligament, ossification of disc herniations, and comparison of ZTE derived imaging of pedicle morphology to the current reformats provided by CT. The ability to image metallic hardware with ZTE will also be assessed, if present; 56 participants.  Other cohorts being added is for those who are returning for aneursym ablation follow-up with medically indicated head MRI (adding reserach ZTE sequence) ...

This study is designed to use new MRI techniques to better understand and treat seizure disorders

The purpose of this study is to develop and evaluate four-dimensional Magnetic Resonance Image (4DMRI) sequence to accurately map tumor motion for radiation treatment.

The purpose of this study is to establish whether exposure to 3.0T MRI acoustic noise can induce temporary or permanent hearing threshold shifts or otoacoustic emissions amplitude shifts in patients using the currently accepted routine hearing protection. 

Assessing disease activity in people with Takayasu's arteritis is difficult, as most people with the disease do not exhibit visible, measurable symptoms. Combination positron emission tomography/computed axial tomography (PET/CT) is a particularly sensitive, accurate scanning method that may improve researchers' ability to evaluate people with the disease. This study will determine the effectiveness of PET/CT in assessing disease activity in people with Takayasu's arteritis.

This is a Phase I study to understand the biodistribution of MM-398 and to determine the feasibility of using Ferumoxytol as a tumor imaging agent.

The purpose of this study is to demonstrate the feasibility of F18- FES PET/MRI in patients with endometriosis, to establish the normal bio-distribution of F18- FES in pre-menopausal women, and to compare the diagnostic performance of F18- FES PET/MRI with that of conventional imaging (ultrasound and MRI alone) using surgical findings as the reference standard.

The purpose of this study is to compare functional MRI images for motor activity in patients with rotationplasty using the nonsurgical limb as an internal comparison.

The purpose of this study is to develop 7T MRI techniques for early-stage detection of cancer, using both hydrogen (1H) and deuterium (2H) imaging. 

The purpose of this study is to assess the advantages of new image processing software to workflow and productivity. This software has been shown in the literature to improve cancer detection.

The purpose of this study is to evaluate the standard Myocardial Blood Volume Measurement (MBV) by Real-Time Myocardial Perfusion Echocardiography (RTMPE) and compare this to the myocardial volume ratio by Cardiac Magnetic Resonance (CMR).

The purpose of this study is to identify clinical factors and mechanisms associated with cardioembolic stroke related to atrial cardiopathy, hypothesizing that impaired left atrial appendage (LAA) velocities and stasis are key determinants. 

The purpose of this study is to build a database to do comparison studies of epilepsy patients and normal controls with Magnetic Resonance Imaging(MRI) and Electroencephalogram (EEG).

This research study will evaluate magnetic resonance (MR) studies (imaging and elastography) to assess methods to estimate liver fat and fibrosis among American Indians (AI) with high rates of obesity, insulin resistance and variable alcohol (EtOH) use. MR examinations in this study are obtained in the same way as routine images are obtained on MR scanners, using radio waves and magnetic fields.

The purpose of this study is to evaluate plasma biomarkers of vascular function and inflammation in patients with newly-diagnosed Obstructive Sleep Apnea (OSA) and pre-existing imaging evidence of Cerebral Small Vessel Disease (CSVD).

The purpose of this research study is testing a new technique for measuring stiffness of the lung. This new technique is called Magnetic Resonance Elastography (MRE). In this study we will look at the stiffness measurements in humans.

The purpose of this study is to see if Magnetic Resonance Elastography (MRE) a recently developed imaging technique can be used to characterize and help stage glioma tumors and evaluate response to therapy.

The purpose of this study is to develop MRE-based imaging biomarkers to measur the mechanical properties of the myofascial interface and determine if there are changes in these parameters in MPS patients and if these parameters can be used to monitor treatment responses and predict patient outcomes.

The objectives of this proposal are to evaluate new MRI software and hardware methods to improve dynamic imaging of the wrist.

The purpose of this study is to characterize the changes occurring in breast tumor-associated properties/ dimensions between the prone and supine imaging positions and to develop a dataset of supine-positioned MRIs that can be translated into an operative setting for real-time visualization.

The purpose of this study is to evaluate changes in CSF dynamics (e.g., velocity, flow rate) between patients with normal pressure hydrocephalus and healthy controls, as well as patients with other dementia disorders.

The purpose of this study is to assess how well multiparametric magnetic resonance imaging (MRI) works in evaluating cancer stage and helping treatment planning in patients with prostate cancer. Multiparametric MRI may be useful for evaluating the type of cancer in finding aggressive disease.

This purpose of this pilot study is to determine if there are changes in mild TBI detectible with MRE. This is the first time this novel technology has been applied to mild TBI and the anticipated results are theoretical.

The purpose of this study is to compare the accuracy of the Auto Registration capability on the EPIQ/PercuNav system against existing manual registration techniques using common anatomical landmarks, for image fusion.

To determine whether PET/MRI can accurately predict complete pathologic response from neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer

To assess the quality of images obtained with a new RF (AIR) coil when compared to those obtained using FDA approved RF coils of patients undergoing MR imaging for radiation therapy treatment planning.

The purpose of this study is to examine the ability of PCD-CT to (1) display subtle fractures of the wrist using the system’s increased spatial resolution compared to conventional wrist CT and MR; and (2)  evaluate the ability of PCD-CT with virtual non-calcium images to identify bone marrow edema at acute fracture sites.

This randomized phase II trial studies how well abbreviated breast magnetic resonance imaging (MRI) and digital tomosynthesis mammography work in detecting cancer in women with dense breast. Abbreviated breast MRI is a low cost procedure in which radio waves and a powerful magnet linked to a computer and used to create detailed pictures of the breast in less than 10 minutes. These pictures can show the difference between normal and diseased tissue. Digital tomosynthesis mammography is a procedure that uses multiple x-rays pictures of each breast to produce a 3-dimensional rendering of the entire breast. Combined screening with abbreviated breast ...

The purpose of this study is to look at a contrast-enhanced MR angiography method in comparison to current methods. The contrast-enhanced method can generate images with more spatial detail and can be used to view a much larger region of the patient’s body than is presently possible.

The purpose of this study is to demonstrate haemorrhage detection sensitivity >80% and specificity >80%.

The purpose of this study is to develop an advanced multiparametric liver magnetic resonance elastography (MRE) imaging technology for monitoring hepatic inflammation during direct acting antiviral (DAA) treatment, evaluation risks of severe liver injury, and HCC development.

The purpose of this study is to develop and test the effectiveness of an investigational imaging technique called magnetic resonance elastography (MRE) to measure the stiffness (mechanical properties) of tissues.

To establish whether ZTE imaging of the infant calvarium can provide equivalent information to CT, specifically in reference to diagnosis for craniosynostosis.

The purpose of this study is to determine whether a posterior fossa decompression or a posterior fossa decompression with duraplasty results in better patient outcomes with fewer complications and improved quality of life in those who have Chiari malformation type I and syringomyelia.

VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute ischemic stroke window for immediate use in clinical trials, and explore these biomarkers in acute intracerebral hemorrhage. VERIFY will create the first multicenter, large-scale, prospective dataset of clinical, transmagnetic stimulation (TMS), and MRI measures in the acute stroke time window.

The purpose of this research is to evaluate the diagnostic role and clinical efficacy of [18F]FET-PET/MRI in detecting MRI-occult primary or residual/recurrent functional pituitary adenomas (PAs) and its influence on clinical and surgical decisions.

The purpose of this study is to assess and deploy a new PET/MR platform following the same quality control method as was done at other Mayo Clinic sites, i.e. Rochester and Arizona.

The secondary purpose is to initiate a data registry for the PET/MR studies allowing us to capture some basic information about the indications, findings, and relevant imaging and non-imaging biomarkers for the studies conducted. This will allow us to see trends in utilization as well as create preliminary data to inform future (IRB approved) investigations.

The purpose of this study is to assess whether patients undergoing a breast MRI (magnetic resonance imaging) before breast surgery will have better results after the surgery. Breast tumors are routinely evaluated using mammograms and ultrasound before surgery. This study would like to find out if using MRI in addition to mammography before surgery improves the ability to evaluate tumors and decide what kind of surgery is best for the patient.

The purpose of this study is to compare the utility of whole body MRI (WBMRI) with diffusion-weighted imaging (DWI) and simultaneous 18F-FDG PET/MRI with time of flight (TOF) PET acquisition to identify and characterize osseous lesions in patients with multiple myeloma.

The purpose of this study is to develop an artificial intelligence (AI) system than can process MR images acquired using conventional acquisition schemes (spin echo, gradient echo, etc) and contrasts (T1, T2, T2*, PD) to identify the MR fingerprint of the tissue under interrogation.

The purpose of this study is to prospectively clarify the long-term consequences of SARS-CoV-2 infection in the CNS with multi-modal magnetic resonance (MR) imaging tracking structural, microstructural, vascular and biochemical changes.

COVID-19 increases the risk of developing long-term inflammatory, neurodegenerative and cerebrovascular consequences.

The purpose of the study is to collect representative clinical images (head and whole-body scans) of demonstrated diagnostic quality using the next-generation SIGNA PET/MR device equipped with investigational software components in adult population. The images and summary data from this study are intended for use in regulatory submission.

The purpose of this study is to develop a localizer for use within the 7T MRI to allow for future clinical use in neurosurgical planning.

The purpose of this study is to create a new Magnetic resonance imaging (MRI) technique with true contrast to the background reference points in functional MR images of individual patients. Functional MRI has been widely used in staging, grading and treatment response monitoring of glioblastoma.  MRI has great soft tissue and tumor tissue contrast and can assist in outlining the target. It has proven able to offer functional information such as cell density, permeability of the micro-blood vessels, and the oxygen level of the tumor.

The purpose of this study is to evaluate the feasibility, safety, and initial effectiveness of ExAblate thermal ablation of a subcortical focal epileptic target area in the brain of patients suffering from medication-refractory epilepsy, using the ExAblate transcranial system to produce multiple sonications targeted in the lesion of interest. The investigators will establish the feasibility and collect data to establish the basic safety of this type of treatment as the basis for later studies that will evaluate its full clinical efficacy.

Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been realized in informing the design of therapeutic trials in AD. ADNI3 continues the previously funded ADNI-1, ADNI-GO, and ADNI-2 studies that have been combined public/private collaborations between academia and industry to determine the relationships between the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of Alzheimer's disease (AD). The overall goal of the study is to continue to discover, optimize, standardize, and validate clinical trial measures and biomarkers used in AD research.

The purpose of this study is to evaluate an attenuation map for a transmit/receive (T/R) head coil used on the GE SIGNA PET/MR system. An attenuation map of the T/R head coil will be developed and evaluated in phantom experiments followed by the patient studies. The repeatability of generating patient-specific attenuation maps from Zero Echo Time (ZTE) MR images acquired with the T/R head coil will also be assessed.

The purpose of this study is to identify early response biomarkers from biological or functional imaging to better align with clinical trial endpoints and minimize sarcoma patient toxicities.

The purpose of this study is to investigate the mechanical properties of breast tissue on MRE (including stiffness, elasticity, viscosity, and volumetric stain) to find any correlation between these variables with breast density and background parenchymal enhancement, both of which are considered independent risk factors for breast carcinoma. We can also assess any suspicious lymph nodes noted on diagnostic MRI and correlate with stiffness values of the lymph nodes on MRI.

The purpose of this study is to evaluate the effects of radiation on normal liver tissue. This will help us develop MRI-based dose range monitoring techniques for liver Stereotactic Body Radio Therapy.

This phase II trial studies how well dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) works in measuring relative cerebral blood volume (rCBV) for early response to bevacizumab in patients with glioblastoma that has come back. DSC-MRI may help evaluate changes in the blood vessels within the cancer to determine a patient?s response to treatment.

Aims, purpose, or objectives:

1. Evaluation of quantitative biomarkers derived from simultaneous time-of-flight FDG PET-MRI/MRCP for assessment of response to neoadjuvant therapy in borderline resectable PDAC.
2. Evaluate the comparative performance of blood and FDG PET-MRI/MRCP based biomarkers for assessment of response to neoadjuvant therapy in borderline resectable PDAC.

The purpose of this study is to examine the relationship of ctDNA status and FDG PET/MRI findings with other clinicopathologic variables and standard staging examinations. We will develop a multivariable model combining ctDNA and FDG PET/MRI biomarkers to predict treatment response and survival. In addition, we will define the quantitative thresholds for early chemotherapy switch in patients who do not respond to first-line chemotherapy.

This study will focus on demonstrating the benefits of Photon Counting Detector CT Scan (PCD-CT) for clinical indications and findings are expected to benefit the diagnosis and characterization of Coronary Artery Disease (CAD) and myocardial perfusion defects.

Specific Aim:  

In patients, measure the clinical impact of cardiac PCD-CT on patient diagnosis and management

This study is designed to assess the ergonomics and ease of use of a new Adaptive Image Receive (AIR) coil system for patients undergoing MR imaging for radiation therapy treatment planning. 

The purpose of this study is to compare pain and function in patients undergoing operative versus non-operative treatment of atraumatic rotator cuff tears at 12 months of follow-up, and to assess effects of rotator cuff tear size and age on comparative outcomes of operative versus non-operative treatments for atraumatic rotator cuff tears.

The first objective of this pilot research protocol is to evaluate the quality of PET from the SIGNA PET/MR system and to compare the quantitative accuracy of PET images from the PET/MR system to PET images from a standard PET/CT system. The second objective of this pilot research protocol is to compare the image quality from MRI images acquired on the SIGNA PET/MR to clinical MR images acquired on a standard 3.0T MRI system.

The primary purpose of this study is to is to develop an advanced multiparametric liver magnetic resonance elastography (MRE) imaging technology for early identification of hepatocellular carcinoma (HCC) involvement, differentiation, and risks of microvascular invasion.

The purpose of this study is to assess the combined impact of post-processing methods that quantify potential biomarkers of chronic liver disease (AEF, fECS) and that improve iodine signal (vMono+) on detecting liver fibrosis and hepatic masses or esophageal varices, in comparison to routine contrast-enhanced liver CT.

The purpose of this study is to compare the accuracy of non-invasive MRE (Magnetic Resonance Elastography) with the results of liver biopsy and/or MRI (Magnetic Resonance Imaging).

The purpose of this study is to evaluate the initial safety and effectiveness of Microburst VNS stimulation in subjects with refractory epilepsy.

The purpose of this study is to evaluate the effects of menopause transition on myocardial stiffness in healthy female subjects without a history of heart disease who are expected to be close to the average age of menopause transition (~51 years), in the 48-53 year age range. All eligible subjects will undergo two study visits that will include a cardiac MRI/MRE exam, echocardiography imaging and blood test.

The purpose of this aim is to characterize the relationship between the serum estradiol level and myocardial stiffness changes in young women (<46) on estradiol replacement therapy after bilateral oophorectomy.  Subjects will be ...

The purpose of this study is to utilize a novel approach of combining advanced radiation delivery with proton beam therapy with advanced tumor visualization with 18F-DOPA PET and MRI imaging. We will study the effectiveness and safety of this technique delivering the entire treatment over 1-2 weeks.

The purposes of this study are to assess gastric motility and emptying with scintigraphy in patients with upper gastrointestinal symptoms, to evaluate the relationship between daily symptoms and GE, motility, and symptoms during a GE study, to assess fasting and postprandial gastric volumes and motility with MRI in patients with upper gastrointestinal symptoms, and to compare gastric motility measured with scintigraphy and MRI.

Investigators will compare magnetic resonance (MR) elastography and/or ultrasound elastography measurements to other forms of noninvasive methods of detecting raised intracranial pressure, including optical coherence tomography (OCT) imaging measurements of the retinal nerve fiber layer (RNFL) and indirect signs of raised intracranial pressure on magnetic resonance imaging (MRI).

The purpose of this study is to evaluate if specific blood, stool and MRI tests can tell the difference between bowel wall inflammation without scarring and bowel wall inflammation with scarring that can cause bowel blockages requiring surgery.

The general aim of this proposal is to evaluate new non-significant risk (NSR) MRI technology in a clinical setting, specifically the use of preclinical (non-FDA-approved) sequences (including but not limited to bSSFP, SSFSE) which have been modified from their standard counterparts to include interleaved 1D body navigator pulses.

The purpose of this study is to combine MRI images with histologic and genetic analysis of cancer (from blood and tissue samples) to improve the overall accuracy of diagnosis and effectiveness of cancer treatment.

The purpose of this study is to determine the performance of Dual-Energy CT (DECT) with Virtual Non-calcium (VNCa) and fat measurement in assessing multiple myeloma disease activity following treatment, with MRI and clinical/ laboratory parameters as reference standards.

The purpose of this study is to determine if cerebral perfusion imaging can identify a subset of patients who are most likely to have a favorable outcome after thrombectomy treatment. We hypothesize that patients with a favorable Critical Area Perfusion Score (CAPS≤3) on cerebral perfusion imaging will have a favorable response to revascularization by thrombectomy and that patients with a CAPS>3 will not.

The purpose o fthis study

A total of 8,000 patients presenting to CPSs with acute-onset AIS, ICH or aSAH and no history of dementia will be enrolled within 6 weeks of stroke onset.

All participants will undergo baseline screening for evidence of pre-stroke dementia. Those who pass baseline screening will complete a blood draw and a series of cognitive and functional assessments at baseline.

Participants will undergo in-person (3-6 months, 18 months) and telephone (annual) follow-up visits for the duration of the study to assess for longitudinal cognitive and functional outcomes. In addition to Tier 1 procedures, at each in-person follow-up visit: Tier ...

Evaluation of TOF FDG PET-MRE for identification of predominantly fibrotic small bowel strictures in Crohn’s disease.

The purpose of this study is to evaluate the feasibility and diagnostic performance of 68Ga PSMA-dual contrast PET/MRI for detection and staging of Hepatocellular Carcinoma (HCC), and to compare it with standard-of-care (SOC) imaging. Additionally, this study aims to identify the biologic correlates of biomarkers derived from 68Ga PSMA-dual contrast PET/MRI with histopathology features and PSMA immunostaining of HCC.

The purpose of this research is to compare two different standard-of-care pre-surgical imaging methods. 

The primary hypotheses are that the TULSA-Procedure is safe and effective treatment of intermediate grade prostate cancer over 2 years. The primary endpoint is defined as the proportion of patients who maintain urinary continence and erectile potency. The effectiveness co-primary endpoint is defined as the proportion of patients free from treatment failure.