A Study to Evaluate Using Pulsed Arterial Spin Labeling Magnetic Resonance Imaging (PASL-MRI) to Study the Function of the Hypothalamus in Anorexia and Obesity


About this study

The purpose of this study is to evaluate if pulsed arterial spin labeling magnetic resonance imaging (PASL MRI) is able to measure a difference in hypothalamic blood flow in patients with anorexia nervosa, opposite than obesity when compared to health.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • 3 groups:

    • Group 1 will include 8 patients with a DSM-5 diagnosis of anorexia nervosa;
    • Group 2 will include 8 healthy normal weight volunteers (BMI 20-25); and
    • Group 3 will include 8 patients with class I-II obesity (BMI 30-40).
  • Age > 18 and ≤ 50 years.
  • Stable weight for 3 months prior to study entry.
  • Able to provide written informed consent prior to any study procedures, and be willing and able to comply with study procedures.

Exclusion Criteria:

  • Any contraindications to MRI.
  • Claustrophobia.
  • Diabetes.
  • Unstable coronary artery disease.
  • Heart failure.
  • Cardiac arrhythmia.
  • Cardiac valvular disease.
  • Obstructive or interstitial lung disease.
  • Pregnancy.
  • Previous gastric surgery.
  • Gastroparesis.
  • Congenital abnormalities of the GI tract.
  • Currently on or prescribed a medication or over the counter supplement known to affect weight or satiety within 3 months of study entry.
  • A positive score on the AUDIT-C questionnaire as judged by an investigator.
  • Patient has a known history of any condition or factor judged by the investigator to preclude participation in the study or which might hinder study adherence.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Andres Acosta, M.D., Ph.D.

Closed for enrollment

Contact information:

Shawna Franks R.N.

(507) 422-6779


More information


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