Evaluating Raised Intracranial Pressure Using MR Elastography


About this study

Investigators will compare magnetic resonance (MR) elastography and/or ultrasound elastography measurements to other forms of noninvasive methods of detecting raised intracranial pressure, including optical coherence tomography (OCT) imaging measurements of the retinal nerve fiber layer (RNFL) and indirect signs of raised intracranial pressure on magnetic resonance imaging (MRI).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Male or female, ≥ 18 year of age.
  • Group 1: : Papilledema from idiopathic intracranial hypertension and others suspected of elevated intracranial pressure, including obstructive hydrocephalus, or suspected biomechanical changes to the eye, such as choroidal fold.
  • Group 2: Patients without raised intracranial pressure.

Exclusion Criteria:

  • Age < 18.
  • Pregnancy (self-reported).
  • Individuals for whom MR is contraindicated.

Eligibility last updated 10/27/21. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

John Chen, M.D., Ph.D.

Open for enrollment

Contact information:

Jessica Morgan C.O.A.

(507) 293-9689


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