A Study of BI-RADS 4 and 5 Lesions that are Malignant and Increased Stiffness on MR Elastography Compared to Lesions that are Benign


About this study

The purpose of this study is to gather measurements of mechanical properties of BI-RADS 4 and 5 lesions in order to test the effectiveness of MR elastography (MRE) in differentiating benign versus malignant disease. We will also test the mechanical properties of bilateral breast tissue on MRE to find any correlation with breast density on mammograms.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • BI-RADS 4 or 5 lesion greater than 1cm on ultrasound.
  • Female patients older than 18 years.

Exclusion Criteria: 

  • Pregnant and lactating females will be excluded (Women of child bearing potential will have a urine pregnancy test administered prior to the MR elastography exam).
  • Patients with implanted devices including aneurysm clips, pacemakers, coils, filters, and electronic pumps will be excluded.
  • Patients under the age of 18 will be excluded. Patient without decision making capacity will be excluded.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Kathleen Brandt, M.D.

Closed for enrollment

More information


Publications are currently not available

Study Results Summary

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Supplemental Study Information

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