A Study of Carotid MRI/MRA to Evaluate the Amount of Plaque in the Arteries of Patients Taking Cholesterol Lowering Medication


About this study

The purpose of this study is to assess if it is possible to use a carotid MRI/MRA to see if cholesterol lowering medication is causing a reduction in the amount of plaque in the arteries.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Adults starting PCSK9 inhibitors for treatment of hypercholesterolemia
  • Able to come back to Mayo for follow-up imaging at 3-9 months and 12-18 months following initiation of therapy

Exclusion Criteria  

  • Pregnant or nursing
  • Are not on PCSK9 inhibitors 
  • Has renal failure
  • GFR < 30   
  • Has claustrophobia
  • Has gadolinium allergy

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

John Huston, M.D.

Closed for enrollment

More information


Publications are currently not available

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