Study to Assess Cardiac Dyspnea Using Exercise Cardiac Magnetic Resonance as a Diagnostic Tool


About this study

The purpose of this study is to assess cardiac dyspnea using exercise cardiac magnetic resonance as a diagnostic tool.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Please contact the study team to discuss whether or not you are eligible to participate in a study.

Inclusion Criteria:

  • Consecutive patients aged ≥ 18 years old.
  • Suspected cardiac dyspnea.
  • Scheduled to undergo right heart catheterization as dictated by a comprehensive examination.
  •  Echocardiography will be included for enrollment.

Exclusion Criteria:

  • Age < 18 years old.
  • Pregnancy.
  • Mechanical ventilation.
  • Acute or chronic renal failure (creatinine clearance < 30 ml/min or requiring renal replacement therapy).
  • Inability to perform MRI (i.e., claustrophobia, severe obesity (>150 kg), device incompatible with MRI).
  • Inability to exercise.
  • Significant arrhythmia that precludes adequate ECG-gating for the MRI (i.e., atrial fibrillation with highly variable cycle lengths).
  • Prior heart or lung transplantation.
  • Left ventricular systolic (ejection fraction < 50%) or diastolic failure (based on Framingham criteria for heart failure with preserved ejection fraction).
  • Significant left-sided valvular disease (≥ moderate aortic stenosis, mitral stenosis, aortic regurgitation, mitral regurgitation) or prior valve surgery.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Brian Shapiro, M.D.

Closed-enrolling by invitation

What is this? (?)
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Carolyne Stevens


More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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