A Study to Determine if Early Changes of Pulmonary Artery Hypertension can be Seen by Adding Exercise During Cardiac Magnetic Resonance Imaging (MRI)


About this study

The purpose of this study is to evaluate the diagnostic benefit of adding exercise to cardiac Magnetic Resonance Imaging to help show early changes that may assist in the earlier diagnosis of Pulmonary Artery Hypertension.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Please contact the study team to discuss whether or not you are eligible to participate in a study.

Inclusion Criteria

  • Consecutive patients aged ≥18 years with confirmed or high clinical suspicion for group 1 Pulmonary artery hypertension as dictated by a comprehensive examination and echocardiography

Exclusion Criteria

  • Under 18 years of age
  • Portopulmonary hypertension (i.e. PAH in the presence of chronic liver disease and confirmed portal hypertension)
  • Pregnancy
  • Mechanical ventilation
  • Acute or chronic renal failure
    • Creatinine clearance <30 ml/min 
    • Requires renal replacement therapy
  • Inability to perform CMR (i.e. claustrophobia, severe obesity (>150 kg), device incompatible with CMR)
  • Inability to exercise adequately as assessed by investigator
  • Significant arrhythmia that precludes adequate ECG-gating for the CMR (i.e. atrial fibrillation with highly variable cycle lengths)
  • Prior heart or lung transplantation,
  • Left ventricular systolic ejection fraction < 50%
  • Diastolic failure based on Framingham criteria for heart failure with preserved ejection fraction
  • Significant left-sided valvular disease such as ≥ moderate aortic stenosis, mitral stenosis, aortic regurgitation, mitral regurgitation
  • Prior valve surgery

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Brian Shapiro, M.D.

Closed for enrollment

Contact information:

Marcia Dubin CCRP

More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


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