A Study of New MRI Markers to Detect the Earliest Phases of Pediatric Multiple Sclerosis


About this study

The purpose of this study is to better understand specific MRI characteristics of different pediatric disorders affecting the brain using new MRI analysis and imaging techniques to detect and understand subtle changes in specific parts of the brain.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Age 18 or below
  • Ability to obtain MRI without sedation
    • This in practice comes down to age > 5-6
  • Evaluation at Mayo Clinic by pediatric neurologist for groups 1-3
  • Group 1
    • Pediatric onset Multiple Sclerosis
    • Clinically isolated syndrome (single demyelinating event with abnormal MRI of the brain)
  • Group 2
    • Non-specific T2 signal change on MRI
    • Clinical history not consistent with MS
    • Acquired or inherited WM disease, e.g. low grade neoplasm, leukodystrophy
  • Group 3
    • Patients with epilepsy
  • Group 4
    • Healthy controls
    • No neurological disease

Exclusion Criteria 

  • Claustrophobia or sedation required to obtain MRI
  • Standard exclusion criteria for MRI, e.g.
    • Pacemaker
    • Implanted device
    • Etc

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Jan-Mendelt Tillema, M.D.

Closed for enrollment

Contact information:

Center for Multiple Sclerosis and Autoimmune Neurology


More information


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