A Study to Evaluate and Monitor Hepatitis Activity in Hepatitis C Virus Infection Patients Using Advanced Multiparametric MR Elastography (MRE)

Overview

About this study

The purpose of this study is to develop an advanced multiparametric liver magnetic resonance elastography (MRE) imaging technology for monitoring hepatic inflammation during direct acting antiviral (DAA) treatment, evaluation risks of severe liver injury, and HCC development.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Please contact the study team to discuss whether or not you are eligible to participate in a study.

Inclusion Criteria:

  • Diagnosis of HCV infection with laboratory test and verified by histological examination.
  • Liver MRE was performed within 3 months of histological analysis.
  • Age ≥ 18 years old.

Exclusion Criteria: 

  • Patients with HBV coinfection (10% a high risk of parenteral transmission).
  • Perinatal transmission (because of the immature immunity system, the infection becomes chronic much easily; cause delayed virus clearance).
  • Patients with HIV infection (lower immune activity).
  • Patients have alcohol abuse.
  • Patients have antiviral treatment between liver biopsy and MRE examination.
  • Any medical condition that, in the opinion of the Principal Investigator, would serve as exclusion criteria for study enrollment.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Douglas Simonetto, M.D.

Open for enrollment

Contact information:

Meng Yin Ph.D.

(507)284-9777

Yin.Meng@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20467518

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