7 Tesla MRI in ALSP Patients


About this study

The purpose of this study is to compare the sensitivity and specificity of ultra-high field MRI (7 Tesla) to standard 3T MRI for the of characteristic imaging findings in the diagnosis of Adult-onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Male or female subjects, aged ≥ 18 years on the day the informed consent form (ICF) is signed.
  • Subjects who are enrolled in IRB 21-006198.

Exclusion Criteria: 

  • Contraindication to either 3T or 7T brain MRI (ineligible metallic implants, < 30 kg or > 115 kg, etc.).

Eligibility last updated 12/15/21. Questions regarding updates should be directed to the study team contact.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Zbigniew Wszolek, M.D.

Closed-enrolling by invitation

What is this? (?)
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Audrey Strongosky C.C.R.C.


More information


Publications are currently not available

Mayo Clinic Footer