Optimizing Pancreatic Cancer Management with Next Generation Imaging and Liquid Biopsy


About this study

The purpose of this study is to examine the relationship of ctDNA status and FDG PET/MRI findings with other clinicopathologic variables and standard staging examinations. We will develop a multivariable model combining ctDNA and FDG PET/MRI biomarkers to predict treatment response and survival. In addition, we will define the quantitative thresholds for early chemotherapy switch in patients who do not respond to first-line chemotherapy.



Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adults > 18 years with treatment-naïve biopsy-proven PDA or with findings diagnostic for PDA on baseline imaging (CT, MRI or PET).
  • Localized disease expected to undergo surgical resection following NAT.
  • ECOG performance status of 0-2.
  • Ability to provide informed consent.

Exclusion Criteria: 

  • Non-PDA histology on biopsy.
  • No baseline PET/CT or PET/MRI.
  • Histopathologically proven metastatic PDA.
  • Non-FDG avid PDA on baseline PET/CT or PET/MRI.
  • Pregnant women.

Eligibility last updated8/25/21.  Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Ajit Goenka, M.D.

Closed-enrolling by invitation

What is this? (?)
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Kurt Kevin Degillo CCRP

(507) 422-5407


More information


Publications are currently not available

Mayo Clinic Footer