Magnetic Resonance Elastography of Dementia


About this study

The purpose of this study is to develop and test the effectiveness of an investigational imaging technique called magnetic resonance elastography (MRE) to measure the stiffness (mechanical properties) of tissues.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Human subjects will be recruited for the project from the Mayo Alzheimer’s Disease Research Center and the clinical practice
  • There will be six groups of subjects in the study including
  • Cognitively normal elderly patients
  • Patients with Alzheimer’s disease
  • Patients with frontotemporal dementia, DLB, PD and seizures
  • Adults ranging in age from 18 to 100 years of age
  • Subjects will be in good general health with the exception of dementia or a history of TBI. Their dementia will not be due to other medical or psychiatric problems.

Exclusion Criteria:

We will exclude individuals with contraindications to MRI scanning such as:

  • Cardiac pacemaker
  • Presence of intraocular or intracranial metallic objects and MRI incompatible devices

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

John Huston, M.D.

Open for enrollment

Contact information:

Timothy Waters

(507) 293-0692

More information


Publications are currently not available

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