Magnetic Resonance Elastography of Dementia


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 11-001066
    Sponsor Protocol Number: 11-001066

About this study


We are doing this research study to develop and test the effectiveness of an investigational imaging technique called magnetic resonance elastography (MRE). This technique measure the stiffness (mechanical properties) of tissues.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Human subjects will be recruited for the project from the Mayo Alzheimer’s Disease Research Center and the clinical practice
  • There will be six groups of subjects in the study including
  • Cognitively normal elderly patients
  • Patients with Alzheimer’s disease
  • Patients with frontotemporal dementia, TBI, DLB and PD
  • Adults ranging in age from 18 to 100 years of age
  • Subjects will be in good general health with the exception of dementia or a history of TBI. Their dementia will not be due to other medical or psychiatric problems.

Exclusion Criteria:

We will exclude individuals with contraindications to MRI scanning such as:

  • Cardiac pacemaker
  • Presence of intraocular or intracranial metallic objects and MRI incompatible devices

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

John Huston, M.D.

Open for enrollment

Contact information:

Laurie Olsen-Holtorf CCRP



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