A Study to Develop an MRI (Magnetic Resonance Imaging) Based System to Identify Persistent Posttraumatic Headaches as Different from Chronic Migraines


About this study

The purpose of this study is to develop an MRI based model to accurately identify persistent posttraumatic headache related to mild traumatic brain injury, as different from chronic migraine.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Adults (18-65 years of age)
  • Meet criteria for one of four groups
    1. persistent post-traumatic headache (i.e. Persistent headaches following a concussion);
    2. chronic migraine without history of head trauma/concussion;
    3. healthy people with no history of migraine or head trauma/concussion;
    4. concussion with no history of migraine and no persistent post-traumatic headaches.

Exclusion Criteria

  • Structural abnormalities that might suggest moderate or severe traumatic brain injury 
  • Other structural brain damage as interpreted by a board certified neuroradiologist
  • History of any significant head trauma in Chronic Migraine and healthy control subjects
  • Attempts will be made to enroll subjects who are not taking headache prevention medications, antidepressant medications, and other medications that could potentially impact imaging findings
  • Have both PPTH and a history of a primary headache disorder such as migraine

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Todd Schwedt, M.D.

Closed for enrollment

Contact information:

Teresa Radam CCRP



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