Clinical Trials

This study aims to address the gaps in physical exam assessment and lack of available time for POCUS exams to provide daily accurate quantitation of markers of pulmonary and systemic congestion by combining lung ultrasound and peripheral pressure monitoring in heart failure patients without altering provider time commitments.

The purpose of this study is to find out if we can use ultrasound to identify people with breathing problems from their vocal cords. Ultrasound machines use sound waves to see inside your body. In this case, we will be looking at the vocal cords in your neck. If we can use ultrasound to see this problem, then we won’t need to use a camera inside of a person’s throat to diagnose this problem.

Traumatic and non-traumatic soft tissue hematomas are frequently encountered in the acute care setting. The incidence of these hematomas appears to be on the rise secondary to the increased use of anticoagulants among older patients for a variety of medical conditions. The management of soft tissue hematomas depends on the accurate diagnosis of any ongoing bleeding as well as of identification of the injured vessel type. While the majority of cases can be managed conservatively, expanding hematomas leading to hemodynamic instability or ongoing blood loss might require embolization or surgical intervention. The mainstay diagnostic imaging modality is multidetector computed tomography ...

The purpose of this study is to determine efficacy of the Philips Lumify ultrasound in detecting the posterior tibial nerve.

The purpose of this study is to determine if disorders such as immune-mediated myopathies and myotonic dystrophy can affect the mechanical properties of muscle which can be detected using ultrasound-based methods.

The purpose of this study is to assess the effectiveness of 2 dimensional shear wave elastography using ultrasound technology, to measure myofascial trigger points and evaluate treatment response.

The purpose of this study is to determine patient and manufacturing factors that influence orthobiologic agent (OBA) product components and determine how they may influence patient outcomes.

The primary purpose of this study is to measure total kidney volume (TKV) from multi-sweep freehand 3D US using a Philips EPIQ scanner with a 2D curved array C5-1 probe and an electromagnetic (EM) orientation tracker attached to the probe, and from panoramic 3D using X6-1 matrix probe. To segment the kidney from US volume in a fully automated manner, we will use deep learning approaches. We will also use MR-based measurements of TKV as the gold standard by which we will evaluate the accuracy of the US based measurements.

The goal of this study is to evaluate the efficacy of B-scan ultrasonography in identifying increased ICP in patients with idiopathic intracranial hypertension via measurement of optic nerve sheath diameter. 

The purpose of this study is to investigate the value of ultrasound imaging of microscopic blood vessels as a new biomarker for identifying the difference between benign and cancerous uterine pathologies, and to compare ultrasound imaging to the diagnostics of MRI and (if available), surgical pathology.

The goal of this proposal is to perform a pilot study in a group of patients (N=20) who have been diagnosed with osteochondritis dissecans (OCD) of the humeral capitellum. This pilot study will allow us to assess the study design, recruitment process, participant retention, and measurement variabilities for planning future large-scale studies.

Osteochondritis Dissecans (OCD) is a joint defect in which a crack forms in subchondral bone leading to separation of subchondral bone and overlying cartilage from the bulk of the bone. For this pilot study, we will be focusing on OCD within the elbow, specifically on ...

There have been a wide variety of techniques suggested for performing stress sonography of the elbow medial ulnar collateral ligament (mUCL) to evaluate for underlying ulnohumeral joint (UHJ) instability. This is clinically relevant when using ultrasound to diagnose mUCL injuries by measuring ulnohumeral joint widening under stress. To assist the ultrasound operator, prior measurement techniques have stabilized, and stress loaded the elbow with a second operator or specialized instrumentation (Telos Device), as well as a two-operator technique. Reliability of these techniques has not been described. This study will attempt to validate a novel single operator technique that does ...

The purpose of this research is to optimize and evaluate the efficacy of strain magnitude imaging of the placental interface using ultrasound techniques for prediction of placental attachment abnormalities in pregnant women at risk.

The purpose of this study is to compare diaphragm excursion (measured with B mode ultrasound) in a small group of healthy subjects with the published values in the curernt literature and to evaluate the sensitivity and specificity of M mode ultrasound, in isolation, and when combined with B mode ultrasound of the diaphragm, in diagnosing neuromuscular disease of the diaphragm.

The purpose of this research study is to obtain knowledge of the elastic and viscous components of the material properties of the arteries in healthy individuals. All soft tissues have both elastic and viscous components, and we are trying to quantify these properties arterial vessels. The aim of the study is to evaluate if these properties are unique indicators of cardiovascular health.

The purpose of this study is to assess and compare the utility of ultrasonographic shear wave elastography (SWE) method as compared to “ABCDE” thickening ratio and fraction method in assessing diaphragm function.

The purpose of this study is to investigate the effectiveness of ultrasound imaging for staging liver steatosis, using liver fat content measured by MRI as the reference standard.

The purpose of this study is to determine the intra-rater and inter-rater reliability of US measurements of meniscal protrusion with and without weight bearing.

The purpose of this study is to use Ultrasound surface wave elastography to measure and compare the tissue thickness and elasticity in normal eyes and eyes with glaucoma. The goal is to understand the association between tissue characteristics and glaucoma.

The purpose of this study is to determine if ultrasound can improve the ability of physicians in training (residents) to palpate the long head of the biceps tendon (LHBT) in the bicipital groove.

The purpose of this study is to assess kidney microcirculation using contrast-enhanced ultrasonography associated with kidney ultrasound elastography among patients who are at risk of sepsis-associated acute kidney injury provides strong predictive ability for AKI and potential therapeutic targets. 

The purpose of this study is to investigate the use of noninvasive ultrasound shear wave elastography and ultrasound blood vessel imaging to evaluate eosinophilic esophagitis.

The purpose of this study is to measure skeletal muscle (such as in the leg) stiffness through adolescence and adulthood using ultrasound. 

The purpose of this study is to determine the accuracy of a new non-invasive device, the Carotid Stenotic Scan (CSS), to check for stenosis of the internal carotid artery (ICA), as compared to a duplex carotid ultrasound.

The purpose of this study is to evaluate the performance of the investigational GE Ultrasound Systems including image quality, under clinical conditions and to obtain feedback from experienced users.

AIMS:

1. Determine the feasibility of measuring velocity of flow across a patent foramen ovale and using this Doppler spectrum to estimate left atrial pressures.

2. Correlate PFO velocity Doppler profile with the degree of diastolic dysfunction.

3. To Correlated PFO velocity and Doppler derived left atrial pressure with left atrial pressure measured during cardiac catheterization in a subset of (n=20) subjects for validation of this methodology.

The purpose of this study is to quantify medial meniscal extrusion with and without a medial knee unloader brace using ultrasonography in patients with isolated medial knee pain.

As CTS is the most commonly diagnosed compression neuropathy of the upper extremity, assessment of severity and treatment response is important crucial to determine the clinical outcomes. Currently, physical examination and overall functional status as well as pre-op electrodiagnostic (EDX) testing are important in determining patient outcome scores and assessing the treatment response. The physical properties of MN and surrounding tissue may be good biomarkers for this evaluation.

SWE is a qualitative and quantitative method for measuring tissue stiffness. There are limited studies on using SWE for diagnosis of CTS , but other aspects of CTS, including the ...

This is a randomized, placebo-controlled, phase 3 clinical trial to evaluate the efficacy and safety of transcranial ultrasound (US) as an adjunctive therapy to tissue plasminogen activator (tPA) treatment in subjects with acute ischemic stroke.

Investigators hypothesis is that as human age increases, the size of the carpal tunnel decreases.

The purpose of this research is to optimize and evaluate the efficacy of strain magnitude imaging of the placental interface using ultrasound techniques for prediction of placental attachment abnormalities in pregnant women at risk and evaluate the placenta condition.

The purpose of this study is is to assess the EPIQ-Affiniti and NG Compact ultrasound systems in a clinical environment and collect clinical data and feedback when compared to the site’s standard ultrasound system.

The purpose of this study is to determine whether prescribing apixaban (Eliquis®) is more effective in treating and preventing pulmonary embolisms and subsequent DVTs than monitoring the calf DVT with ultrasound imaging alone.

This study is designed to answer the question of whether injection of the greater occipital nerve at its proximal origin, near the C2 vertebrae, using ultrasound guidance is effective in improving pain in human subjects.

HYPOTHESES

1. Ultrasound (US) guided greater occipital nerve (GON) injections are effective at a novel, proximal C2 location in live, human subjects, measured by improvement in visual analog scale (VAS) pain scores pre-injection compared to VAS scores 30 minutes post-injection, 2-weeks post-injection, and 1-month post-injection.
2. Ultrasound (US) guided injection of the greater occipital nerve (GON) at a novel, C2 location is effective at improvement of both occipital neuralgia and ...

Liver stiffness measured by MRE can be used for liver fibrosis staging. However, MRE is expensive and not as widely available. The GE Logiq E9 ultrasound scanners in Radiology department can now make shear wave elastography (SWE) measurements. Before these scanners can be used for making clinical measurements for liver fibrosis staging, it is important to evaluate the reliability of SWE measurements on the Logiq E9. The aims of this study are to train sonographers for making SWE measurements,  estimate the variability of the SWE measurements, and estimate the correlation of SWE and MRE measurements.

Aim 1 of this project will be entirely cadaveric and, thus, classified as not-human-subjects research by the Mayo Clinic IRB. Eight fresh-frozen cadaveric lower extremities (no history of knee trauma; < 50 years of age) will be acquired from a vendor that has provided >50 specimens with similar criteria in the past three years.5 Specimens will be thawed 24 hours prior to testing. 3D musculoskeletal (MSK) US images of the ACL in the intact knee will be acquired with an Aixplorer Mach 30 (SuperSonic Imagine, Bothell, WA). Literature described imaging techniques from both the anterior and posterior aspect ...

The purpose of this study is to determine if ultrasound surface wave elastography (USWE) produces different recording patterns in healthy and lymphadematous limbs, to establish the relationship between USWE recording values and stages of lymphedema, and to understand the correlation between USWE lymphedema evaluation and other tracking modalities.

The purpose of this study is to compare the use of ultrasound to traditional xrays to evaluate fracture healing over time in patients with radius/ulna (arm) fractures.

The purpose of this study is to develop and validate a new ultrasonic method for assessment of infant bone by evaluating structural and mechanical characteristics of infant tibia.

The overall goal is to investigate the value of ultrasound imaging of tumor vasculature as a new biomarker for early treatment evaluation.

The purpose of this study is to observe newly-graduated CRNAs and their skills level in placing arterial lines using palpation vs. ultrasound guidance method.

The primary aim of the project is to examine the validity and reliability of a portable ultrasound unit for the measurement of the median nerve at the distal palmar crease of the wrist.. We hypothesize the portable ultrasound unit will serve as an acceptable and reliable method for the measurement median nerve diameter. The secondary aim of this project is to examine the validity of a portable ultrasound unit for assessing muscle thickness compared to a high resolution ultrasound unit. 

The purpose of this pilot study is to see if recruitment maneuvers performed during ICU care in patients who have a breathing tube are useful in assessing a blood volume status based on changes in their blood pressure during the recruitment maneuver. The recruitment maneuver consists of increasing the pressure of the breath given through the breathing tube, and is commonly done as a standard part of ICU care for patients who are connected to a machine that helps them breathe. Results will be compared to ultrasound measurements of the main vein of the body (inferior vena cava) which serve ...

The purpose of this study is to evaluate strain imaging, 3-D volume ultrasonography and elastic properties of thrombus to determine if these properties can be used to evaluate the age of thrombus. 
 

The overall goal is to investigate the value of ultrasound imaging of small vasculature as a new biomarker for cancer characterization and early treatment evaluation.

Liver biopsy is routinely performed at day 7 after liver transplant at Mayo to evaluate acute liver rejection.The purpose of this study is to assess the feasibility of a non-invasive evaluation of acute liver rejection by using ultrasound measurements.

The researchers are trying to see whether contrast-enhanced ultrasonography, shear wave elastography, strain imaging, and 3-D volume ultrasonography improves arterial wall visualization and identifies arterial elastic properties among individuals with fibromuscular dysplasia (FMD), atherosclerosis, personal history of spontaneous coronary artery dissections (SCAD), or personal history of segmental arterial mediolysis (SAM) that may be different compared to those without the aforementioned conditions.

The purpose of this study is to find out the optimal acquisition parameters for ultrasound microvessel imaging in healthy volunteers. 

The goal of this study will be to determine the false positive rate of the ultrasonographic Adson and Military press maneuvers for thoracic outlet syndrome (TOS) and to determine interpreter variability among ultrasound technicians.

Specific Aim of this protocol is to measure bladder wall stiffness and compliance by Ultrasound Bladder Vibrometry (UBV) in a group of healthy volunteers. The goal is to obtain normal range of bladder elasticity in and its normal variations in different bladder volumes and in two different positions, standing and supine positions.

The purpose of the study is to assess the Motion Compensation functionality on EPIQ ultrasound system in a clinical environment.

The purpose of this study is to evaluate effectiveness of point-of-care ultrasonography (POCUS) tele-education compared to conventional hands-on training and self-learning in image acquisition by assessing the image appropriateness obtained in the post-training simulation-based skill testing.

The purpose of this study is tp evaluate the effectiveness of quantitative ultrasound bladder vibrometry (QUBV) as a noninvasive tool for detrusor overactivity assessment and for BPH treatment selection.

The purpose of this study is to develop an ultrasound based detection and classification system that achieves high negative predictive value and specificity for malignancy, which could reduce unnecessary biopsies.

The purpose of this pilot and feasibility study is to evaluate intravascular volume changes occurring after recreational scuba diving, as assessed by point-of-care ultrasonography.

The purpose of this study is to determine if lung ultrasound surface wave elastography (LUSWE) can accurately detect changes in lung elasticity (compliance) caused by the presence of extravascular lung water  (pulmonary edema).

The purpose of this study is to investigate the value of ultrasound imaging of small blood vessels and tumor stiffness as a new biomarker to characterize the disease and evaluate early treatment for cancer.

The purpose of this study is to use ultrasound to detect variations in nerve, tendon and subsynovial connective tissue mobility in patients with carpal tunnel syndrome may be useful as functional biomarkers that serve as predictors for treatment response. To test this patients presenting for treatment of carpal tunnel syndrome will be monitored by ultrasound and by clinical assessment before and after non-surgical and surgical treatment.  The clinical outcomes will be alined with the initial ultrasound motion patterns.

The purpose of ths study is to evaluate a contrast-free ultrasound tool for the visualization and quantification of tumor microvessel morphologies, called quantitative high-definition microvessel imaging (qHDMI). This technology includes three components: (1) novel processing procedures to reveal small microvasculatures using high frame rate ultrasound imaging; (2) quantification procedures to analyze the morphology of the microvasculatures in terms of 10 parameters (e.g., tortuosity, branch angle, number of branch points, etc.); and (3) a classification method to automatically determine if the lesion is benign or malignant based on its morphological signature. 

The proposed technique is noninvasive, affordable, portable, and ...

The purpose of this study is to provide objective evaluation of the knowledge, skills, and behaviors of advanced practice providers (APP) trained to perform a focused cardiac ultrasound (FCU) in order to improve the delivery of care and reduce patient and hospital costs.

The purpose of this study is to investigate the value of ultrasound imaging of tumor microvasculature and stiffness as new biomarkers for evaluation of liver tumor.

This study is being done to:

• Test an investigational stiffness measurement and imaging method on the lymph node found in the underarm area.

• Compare investigational imaging to sonography images.

• Compare investigational information to FDA approved US elasticity imaging conducted by SuperSonic Imaging (SSI) machine on the same lymph node in your underarm area.

• Compare to FDA approved ultrasound stiffness imaging system (GE Logiq E9)

• Compare to ultrasound images using Alpinion clinical ultrasound platform, FDA approved ECUBE 12and a non-FAD approved ECUBE 12R

The purpose of this pilot study is to analyze the effectiveness of a new ultrasound microvessel imaging technology for evaluation of synovitis in patients with rheumatoid arthritis.

The purpose of this study is to evaluate an ultrasound technology that may be used to evaluate liver fibrosis.

The purpose of this study is to find out if advanced ultrasound studies can be used to make a diagnosis of giant cell arteritis. Ultimately, we hope to be able to offer non-invasive diagnostic options as an alternative to biopsy to future patients who are being evaluated for giant cell arteritis.

The overall objective of this study is to assess the reproducibility of carotid doppler velocity measurements in the presence of disease.

This phase II trial studies the performance, including ultrasound visibility, of an optimized ultrasound twinkling marker in imaging lymph nodes in patients with clinically node-positive breast cancer. In patients with biopsy-proven breast cancer, biopsy markers are used to identify the sites of cancer involvement in both the breasts and lymph nodes. These biopsy markers are critical for guiding surgical management many months after the marker is placed. For breast radiologists and breast surgeons, there is a need for simple, consistent visibility of biopsy markers by ultrasound, particularly several months after marker placement. Ultrasound is the imaging method of choice, particularly ...

The study will assess whether protein-containing clear liquids have similar gastric emptying time as carbohydrate-based clear liquids.Some commercially available beverages have been advertised as clear liquids yet contains whey protein isolates.These protein-containing clear liquids can be easily confused as carbohydrate-based clear liquids by the patients.However, the gastric emptying time the protein-containing liquids has not been established.The study will assess specific sonographic characteristics of stomach containing solid food.The study will assess if a novice ultrasonographer is able to reproduce the results of gastric contents and volume as an experienced ultrasonographer.

The purpose of this study is to gain knowledge about the elastic and frictional parts of arterial tissues in healthy people and in people with cardiovascular disease.

The purpose of this study is to develop novel ultrasonographic methods for the evaluation and diagnosis of hand pathology.

The purpose of this study is to evaluate the effectiveess of a new 3D ultrasound imaging technology combining B-mode, microvessel imaging, shear wave elastography, and machine learning for breast lesion diagnosis.

The purpose of this research is to evaluate the efficacy of a new breast tissue assessment tool that provides new diagnostic information about breast masses and potential for early classification of malignant masses.

This study is being done to:

• Test an investigational breast imaging system;

• Image the breast and see if we can differentiate lesions by using the investigational imaging system;

• Test an investigational breast stiffness measurement method

• Test and compare to an FDA approved ultrasound stiffness imaging system (GE LOGIQ E9 (LE9)

• Compare to ultrasound images using Alpinion ...

The overall goal of this study is to investigate the improvement of sensitivity and penetration of a new contrast enhanced ultrasound (CEUS) technology over those of traditional CEUS.

The purpose of this research is to use new ultrasound-based methods to measure the mechanical properties of arteries.

The purpose of this study is to utilize direct visualization of proximal arterial occlusion via point-of-care ultrasonography (POCUS), with an eventual goal of developing a simple, inexpensive model for both assessment and instruction of hemorrhage control.

The researchers are trying to determine if the characterization of "vulnerable" carotid artery plaques can be accomplished with ultrasound-based methods that look for vessels in the plaque and measure the plaque stiffness.

The aims of this study are to assess the clinical efficiency of utilization of a dual-plane simultaneous view ultrasound probe (Butterfly iQ+; Butterfly Network, Inc.) during arterial catheter placement in the operating room. Outcome metrics to include: number of attempts for successful cannulation, amount of time to complete procedure, percent of failed attempts / total attempts, and to assess end-user response to use of dual-plane probe via subjective feedback.

The goal of the project is to develop and test a new 3D Doppler technology, with enhanced vessel sensitivity than conventional Doppler, to employ tumor vascularity as a differential biomarker for improved cancer diagnosis and reduced unnecessary biopsy on benign tumors

The purpose of this study is to evaluate whether ultrasound can detect medial meniscal extrusion more frequently than MRI.

The overall goal is to investigate the value of ultrasound imaging of small vasculature as a new biomarker for cancer characterization and early treatment evaluation.

The purpose of this study is to evaluate the effectiveness of ultrasound reduction imaging for liver steatosis grading using Proton Density Fat Fraction (PDFF) measured by magnetic resonance imaging (MRI) as the reference standard.

The purpose of this study is to determine if the AI generated results are less arduous than manual tracing by radiologists, and to determine the non-inferiority of the quality of AI vs manual tracing.  These aims will be evaluated in a clinical environment to investigate the impact of an AI algorithm on the clinical workflow.

The specific aims of this study are as follows:

Aim # 1:  To determine the prevalence of pancreas solid tumor intratumoral microbiota, their composition and diversity in specimens prospectively acquired via endoscopic ultrasound (EUS).

Aim # 2:  To investigate both the oral and duodenal microbiome of such patients to evaluate for similarities and differences.

A combined molecular breast imaging / ultrasound system will enable coregistration of a functional abnormality seen on Molecular Breast Imaging (MBI) with the corresponding anatomical abnormality seen on ultrasound.

The aims of this study are to:

1. Study the history of esophageal leiomyomas in patients followed with periodic surveillance with endoscopic ultrasound.

2. Determine baseline characteristics and symptoms of patients diagnosed with esophageal leiomyomas.

3. Determine the transformation rate of malignancy or symptoms (if previously asymptomatic) in patients who undergo interval surveillance EUS examinations for esophageal leiomyomas.

4. Determine risk factors for progression of symptoms or malignancy in patients followed with interval surveillance EUS exams for esophageal leiomyomas.

5. Assess morbidity and mortality in patients followed with interval surveillance EUS examinations for esophageal leiomyomas.

6. Identify malignant sub-epithelial tumors, including leiomyosarcomas, granular cell tumors, and gastrointestinal stromal tumors (GIST) to see ...

The short-term goal of the proposed research is to develop a new method for viscoelasticity imaging of breast that can work with any type of wave, and not restricted to plane shear waves.

The long-term goal of this project is to develop an ultrasound-based breast imaging technique to improve the diagnostic specificity in breast cancer.

The purpose of this study is to compare the effectiveness of ultrasound with magnetic resonance (MR) enterography in the diagnosing and monitoring of Crohn's disease.

Hypothesis: Identification of vulnerable atherosclerotic plaques (with or without neovascularization) using carotid CEUS is an independent predictor of MACE (over clinical risk factors, stress echo wall motion results, and carotid ultrasound two-dimensional speckle tracking strain indices).

Primary Aims:

1. Evaluate the diagnostic role of carotid CEUS and two-dimensional speckle tracking strain imaging for detection of carotid plaque:

   • To determine the feasibility and safety of Carotid CEUS and Two-dimensional speckle tracking strain imaging SE .
   • To determine if carotid CEUS and two-dimensional speckle tracking strain imaging findings are associated ...

The purpose of this study is to evaluate the use of bedside ultrasound for confirmation of intrauterine contraception (IUC) compared to formal radiology evaluation (standard of care) when IUC location is in question.

The purpose of this study is to compare the accuracy of ultrasound to MRI for the diagnosis and characterization of tears in the ulnar collateral ligament (UCL) of the thumb.

The purpose of this study is to determine the feasibility of ultrasound microvessel imaging to image patient kidneys in vivo.
 

The purpose of this study is for evaluating an ultrasound-based technology (similar to standard clinical echocardiography) for measuring the stiffness of your heart muscle and your peripheral arteries. This type of information may prove to be clinically important.

The purpose of this study is to test the feasibility of NanoString digital spatial profiling (DSP) and RNAscope™ on prospectively acquired HDLN tissue samples with EUS-FNB in patients with unresectable perihilar CCA undergoing liver transplant (LT) evaluation.

The purpose of this study is to describe the findings and outcomes of patient undergoing contrast-enhanced harmonic endoscopic ultrasound (CE-EUS) imaging. A registry will be created to monitor for possible procedure adverse events and to perform descriptive statistics for the patients who undergo this procedure.

Aims:

1.To assess the accuracy of limited ultrasonography of internal jugular vein (IJV), subclavian vein (SV), and inferior vena cava (IVC) for non-invasive measurement of central venous pressure (CVP)

Lymphaticovenous anstomosis is an effective surgery to treat lymphedema in the upper extremities secondary to cancer treatment. A crucial step is to identify patent lymphatic channels. Contrast enhanced ultrasound (CEUS) with intradermal injection of microbubbles is a promising method for lymphatic mapping in the upper extrmeities with lymphedema. The goals of the study are(1) to establish the preferred FDA approved microbubble agent (Lumason, Optison, Definity) for CEUS lymphatic mapping, (2) to identify lymphatic channels with CEUS and high-frequency ultrasound in patients receiving lymphaticovenous anastomosis surgery for upper extremity lymphedema, (3) and to validate the use of shear wave elastography for detecting improving in ...

The purpose of this study is to get surgeon feedback on the use of Google Glass and the MedCyclops software during surgery.

The purpose of this study is to evaluate sensitivity and specificity of 3D ultrasound in the assessment of tumor diameter and myometrial invasion in endometrial cancer in a pre-operative setting. This research is aiming to avoid the performance of sentinel node biopsy in patients at low risk of lymphatic spread.

This study is being done to determine how well a needle can be placed into your knee joint with the use of an ultrasound machine for guidance and to find out if specific nerves can be reached with anesthetic or placebo to prevent the pain in the knee. We are interested if we can reach the specific nerve that will be anesthetized to prevent the pain.

The purpose of this study is to determine the safety of Ultrasound-guided Tenotomy (USGT) by describing the rate and types of USGT-related complications at the Achilles, and to demonstrate the feasibility of an RCT (randomized control trial) at each site by measuring the patient volume per year treated with USGT for Achilles Tendinopathy (AT), and capture rate utilizing a standardized ultrasound imaging protocol for AT.

The research is about the post-procedure outcomes and is not about the ultrasound device or the ultrasound-guided tenotomy procedure.

The purpose of this study is to:

1. To determine whether the presence of pleural effusion measured by bedside ultrasound in the immediate pre-liver transplant period is associated with worse postoperative outcome as compared to no pleural effusion
2. To determine the prevalence of pleural effusion in the immediate pre-liver transplant period measured by lung ultrasound, as compared to the prevalence measured by routine pre-transplant chest imaging

The aim of this study is to prospectively validate the novel AI based model in patients undergoing clinically indicated transthoracic echocardiography using a four-chamber view acquired with a hand-held point of care ultrasound.

The purpose of this study is to test the accuracy and comfort of self-directed ultrasound imaging of cervical dilation and length in participants undergoing induction of labor. The study will assess correlation of cervical measurements between self-directed imaging and experienced provider digital cervical examinations. Experienced providers performing digital cervical examinations will be blinded to ultrasound images and measurements.  Participants will be randomized to undergoing digital cervical examination or ultrasound imaging as initial modality to assess cervical measurements.

The purpose of this study is to prospectively validate a new Artificial Intelligence (AI)-based model developed by our team to analyze TVUS images for early EC detection.  

The purpose of this study is to evaluate the safety and ablation efficacy of the ExAblate UF V2 System when treating symptomatic uterine fibroids. The ExAblate System is a medical device that involves a focused ultrasound system and an MRI scanner. ExAblate delivers a pulse of focused ultrasound energy, or sonication, to the targeted tissue. In this particular study, the targeted tissue is uterine fibroids. Each sonication is used to heat small spots in the fibroid much like a magnifying glass can be used to focus light to heat a spot. The heat created kills a portion of the fibroid ...

The purpose of this study is to compare the use of ultrasound guidance and nerve stimulator guidance with a popliteal (knee) nerve block for postoperative pain control.

The purpose of this study is to investigate the use of shear wave elastography to assess diastolic heart muscle stiffness for diastolic heart failure patients, and compare the stiffness measurements with the cardiac catheterization (cath lab) results.

The purpose of this study is to evaluate the usefulness of combining a core liver biopsy guided by endoscopic ultrasound and stomach balloon placement by endoscope for the diagnosis and treatment of fatty liver disease and obesity.

The purpose of this study is to evaluate post-mastectomy skin perfusion after mastectomy and before radiation, after radiation and after fat grafting to the breast.  A non-FDA approved Ultrasonic Doppler device that implements two techniques (Higher-Order Perfusion Estimation (HOPE) and non-contrast-ultrasound microvasculature morphometric analysis (NUMMA)) will be used to assess these parameters. The information obtain in this study will help decision making on the use of fat grafting for post-mastectomy radiated patiets and eventually reduce the complications and improve clinical outcomes.

Statistical analysis using logistic regression, linear regression and cox models will be performed. Statistical significance will be ...

The goal of the proposed project is to develop a new type of quantitative ultrasound, based on a fundamentally new mechanism of generation of acoustic waves in bone that allows evaluation of bone properties in a wide frequency range.

The purpose of this study is to determine the diagnostic performance of the nonlinear elasticity parameter mapping method by associating its results with pathology in a population of patients with suspicious breast masses.

The purpose of this study is to address a knowledge gap. Early diagnosis of nerve root avulsion injuries following brachial plexus trauma remain a barrier to the early treatment of these complex injuries.  Traditionally, an observation period of 6 months following brachial plexus injuries has been utilized to allow for reinnervation.  Reinnervation is not possible in the setting of nerve root avulsion from the spinal cord and waiting for reinnervation in this setting unnecessarily delays treatment and potentially compromises outcome.  Having the ability to provide a real time evaluation of nerve root integrity would obviate the need of other more ...

The purpose of this study is to assess the effectiveness of a new ultrasound technique for non-invasive evaluation of liver fibrosis.

The purpose of this study is to implement a rapid hemodynamic heart-lung protocol performed at the bedside by cardiology and critical care fellows and subsequently correlate ultrasound-derived hemodynamic parameters with PAC-derived parameters. 

The purpose of this study is to compare the accuracy of the Auto Registration capability on the EPIQ/PercuNav system against existing manual registration techniques using common anatomical landmarks, for image fusion.

Our goal is to determine if the stiffness of supraspinatus muscle can be measured non-invasively before surgery, using ultrasound B-mode together with a new ultrasound technique called Shear Wave Elastography (SWE). The hope is that this assessment of muscle stiffness before surgery will help the doctors to plan the best surgical approach.

The aims of this study are to correlate quantitative Lung Ultrasound (LUS) with gold-standard invasive hemodynamics during exercise in a continuous fashion, to use pulmonary thermodilution for dynamic Extravascular Lung Water (EVLW) measurements to allow direct correlation with sonographic interstitial lung thickening (B-lines) both at rest and during maximal effort exercise, and to examine how development of EVLW and B-lines relates to exercise capacity, symptoms and ventilatory control.

The purpose of this study is to evaluate whether or not the diaphragm and abdominal muscle thickness determine the duration of mechanical ventilation in adult critically ill patients.

The purpose of this study is to evaluate the feasibility, safety, and initial effectiveness of ExAblate thermal ablation of a subcortical focal epileptic target area in the brain of patients suffering from medication-refractory epilepsy, using the ExAblate transcranial system to produce multiple sonications targeted in the lesion of interest. The investigators will establish the feasibility and collect data to establish the basic safety of this type of treatment as the basis for later studies that will evaluate its full clinical efficacy.

In patients with breast cancer which has metastasized to the lymph nodes under the arm, treatment involves marking one of the metastatic nodes at the time of needle sampling for later removal after months of systemic therapy before surgery. When patients respond well to systemic therapy, the marked node can be hard to find by ultrasound, the imaging modality of choice. Mayo has designed a marker that is conspicuous by ultrasound and has shown short-term safety and good performance in a Phase 0 Clinical Trial. This study investigates the hypothesis that the Mayo marker will be safe, detectable by ultrasound, and minimally ...

The purpose of this study is to evaluate the diagnostic performance of Endoscopic Ultrasound (EUS) shear wave elastography in the assessment of liver fibrosis compared to magnetic resonance (MR) elastography.

The purpose of this study is to to demonstrate the feasibility of performing ultrasound-guided erector spinae plane blocks in the Emergency Department (ED) and Intensive Care Unit (ICU).

We purpose of this study is to evaluate the diagnosis accuracy of the Controlled Attenuation Parameter (CAP) measured by FibroScan® (both with M and XL probes) in all patients who are undergoing liver biopsy for any liver disease.  

The purpose of this research study is to gather information on the feasibility of performing novel molecular analysis on Endoscopic Ultrasound acquired cytologic material and to assess molecular changes in cytology samples to see if that may aid treatment decision planning for future patients.

The purpose of this study is to evaluate the accuracy of diagnosis with contrast enhanced digital mammography when used in addition to standard mammography or ultrasound in patients with suspicious findings.

The purpose of this study is to perform and analyze standard transthoracic echocardiography with contrast and strain imaging in 80 consecutive patients seen in the Mayo Clinic Spontaneous Coronary Artery Dissection (SCAD) Clinic and interpret any prior pre- or post-SCAD echocardiogram studies for comparison.

This study is being done to test the feasibility and accuracy of using an ultrasound-guided core needle biopsy technique as a potential tool for staging urothelial carcinoma of the bladder (UCB).

The objective of the study is to determine if there is a difference in ultrasound image quality of the interscalene block anatomy, at point of care, pre- versus post-operatively in a cohort of patients undergoing shoulder arthroscopy who routinely receive blockade of the brachial plexus for postoperative analgesia.

The primary hypotheses are that the TULSA-Procedure is safe and effective treatment of intermediate grade prostate cancer over 2 years. The primary endpoint is defined as the proportion of patients who maintain urinary continence and erectile potency. The effectiveness co-primary endpoint is defined as the proportion of patients free from treatment failure.

The primary purpose of this study is to assess the feasibility of performing lung and kidney and lung ultrasound elastography among patients with critical illness from different etiologies that could be associated with volume overload.

The purpose of this research study to help us understand whether a type of ultrasound can measure bladder stiffness (or compliance).

The purpose of this study is to benchmark the feasibility of carotid artery biomechanical analysis and vertebral-basilar Transcranial Doppler (TCD) as markers of vascular involvement in presbyacusis and presbyvestibulopathy.

The purpose of this study is to document the primary investigator’s clinical experience performing Ultrasound Guided Carpal Tunnel Release (USCTR) in the clinic procedure room setting through retrospective and prospective analysis of these now routinely collected clinical outcomes. 

The purpose of this study is to evaluate the lateral flow assay (LFA) to be used in conjunction with imaging and existing biomarkers in diagnosed or at-risk-for pancreatic cancer patients.

The purpose of this study is to compare the incisionless thread carpal tunnel release with the standard mini-open carpal tunnel release (standard of care) in patients with bilateral carpal tunnel syndrome.

The purpose of this study is to to better understand the concerns of patients prior to a breast biopsy so that we may improve our practice and ultimately enhance overall patient experience.

This is a Phase 0 clinical trial to evaluate a twinkling biopsy marker (Patent Application Title: Non-Metallic Ultrasound-Detectable Markers Patent Application No.: 62/903,078, Application Type:  Provisional) for ultrasound conspicuity in patients with breast cancer and locally advanced disease involving the axillary lymph nodes.

The purpose of this study is to determine whether contrast-enhanced ultrasound (CEUS) can be used in diagnostic evaluation of breast lesions that cannot be seen using contrast-enhanced MRI (CEMR) and contrast- enhanced dual energy mammography (CEDM).   If so, patients can undergo US guided biopsy which is more comfortable for patients and more cost effective.

The purpose of this study is to to map out the extent of Skin Angiosarcoma disease using ultrasound. This will be compared to the MRI and or PET/CT and with clinical and photographic determination of disease extent confirmed with clinically requested punch biopsies. The patient will be scanned with a commercially avilable GE Logiq 10 machine and then with the 25-30 MHz linear microvessel transducer  for microvessel imaging. These scans will be obtained pretreatment, after 2 cylces of neoadjuvant chemotherapy and after completion of neoadjuvant chemotherapy and radiation therapy prior to surgery. 

The purpose of this study is to apply new microvasculature imaging for differentiation of breast lesions, and prediction of response to preoperative chemotherapy.

The purpose of this study is to combine recent advances in ultrasound imaging, specifically an endonasal transducer array and contrast enhanced ultrasound, to offer an intraoperative image-guided solution for lesion-specific surgical resection to impact clinical outcome. 

To determine the efficacy of using MRI/US fusion imaging technology to direct focal ablation of prostate tissue using nanoparticle-directed laser irradiation.

The overall goal of this project is to study a new 3D ultrasound imaging technology for evaluation of axillary lymph nodes in patients with breast cancer.

The primary aim of this study is to determine if there is any evidence of viral shedding within the gastrointestinal or pulmonary system in patients with a prior recent negative nasopharyngeal PCR test. This will be of critical importance to the practice of endoscopy during this pandemic as it will help:  1) determine if a pre-endoscopy testing strategy is adequate to ramp-up access to semi-urgent and eventually elective procedures, while allowing the decreased utilization of limited or costly personal protective equipment (e.g., N95 respirators) while still keeping the GI endoscopy staff safe; and 2) realize the false negative rate of pre-procedural testing, which is vital to inform procedural practice policy and operations.