A Study to Assess Neuromuscular Ultrasound to Predict the Duration of Mechanical Ventilation.


About this study

The purpose of this study is to evaluate whether or not the diaphragm and abdominal muscle thickness determine the duration of mechanical ventilation in adult critically ill patients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adult ICU patients in the Mayo Clinic Rochester who undergo mechanical ventilation,
  • Patients who meet at least 2 of the following criteria within 2 hours preceding intubation:
  • Heart rate measurement is within 2 hours preceding intubation:
    • Heart rate > 100 beats per minute.
  • BUN, pH, Creatinine, and HCO3 measurements are from the most recent laboratory data prior to intubation:
    • BUN > 25 mg/dL;
    • pH < 7.25;
    • Creatinine > 2.0 mg/dL;
    • HCO3 < 20 mEq/L.

Exclusion Criteria: 

  • Patients who decline research participation.
  • Patients who are mechanically ventilated transiently for a procedure.
  • Patients with documented history of neuromuscular disorder or diaphragmatic paralysis at the time of mechanical ventilation.
  • Patients who underwent thoracic or abdominal surgery within 1 month of study enrollment or during the current hospitalization.
  • Patients who cannot undergo neuromuscular ultrasound, due to the presence of medical tubes and dressings at the site of ultrasound transducer application.
  • Patients who are receiving palliative care/comfort measures only.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Hiroshi Sekiguchi, M.D.

Contact us for the latest status

Contact information:

Hiroshi Sekiguchi M.D.



More information


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