Ultrasound Utility in Carpal Tunnel Syndrome


About this study

As CTS is the most commonly diagnosed compression neuropathy of the upper extremity, assessment of severity and treatment response is important crucial to determine the clinical outcomes. Currently, physical examination and overall functional status as well as pre-op electrodiagnostic (EDX) testing are important in determining patient outcome scores and assessing the treatment response. The physical properties of MN and surrounding tissue may be good biomarkers for this evaluation.

SWE is a qualitative and quantitative method for measuring tissue stiffness. There are limited studies on using SWE for diagnosis of CTS , but other aspects of CTS, including the assessment of severity and treatment response have not been studied. Our central hypothesis is that SWE provides quantitative information about the physical properties of the MN and surrounding tissue that help to identify carpal tunnel syndrome, its severity and response to treatment. If SWE successfully demonstrates efficacy in diagnosing, patient outcome score, and treatment response assessment, it would have a significant clinical impact on patients with CTS, as well as offering an additional confirmatory diagnostic test for true recurrent carpal tunnel syndrome.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria: 

  • Male and female volunteers.
  • Age ≥ 18 years old.
  • Having symptom of claudication and suspected PAD.
  • Scheduled for vascular testing.

Exclusion Criteria: 

  • Individuals less than 18 years of age.
  • Prior surgery.
  • People considered in “vulnerable” populations.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Azra Alizad, M.D.

Contact us for the latest status

Contact information:

Patricia O'Neil

(507) 284-1375


Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Kevin Renfree, M.D.

Open for enrollment

Contact information:

Carter Jones M.S., CCRP

(480) 342-6003


More information


Publications are currently not available

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