Subepithelial Esophageal Lesions: The Mayo Clinic Experience

Overview

About this study

The aims of this study are to:

  1. Study the history of esophageal leiomyomas in patients followed with periodic surveillance with endoscopic ultrasound.

  2. Determine baseline characteristics and symptoms of patients diagnosed with esophageal leiomyomas.

  3. Determine the transformation rate of malignancy or symptoms (if previously asymptomatic) in patients who undergo interval surveillance EUS examinations for esophageal leiomyomas.

  4. Determine risk factors for progression of symptoms or malignancy in patients followed with interval surveillance EUS exams for esophageal leiomyomas.

  5. Assess morbidity and mortality in patients followed with interval surveillance EUS examinations for esophageal leiomyomas.

  6. Identify malignant sub-epithelial tumors, including leiomyosarcomas, granular cell tumors, and gastrointestinal stromal tumors (GIST) to see if there was a history of benign neoplasm preceding their diagnosis.

  7. Evaluate symptom progression in follow up by contacting patient to complete a validated, brief questionnaire (BEDQ: Brief Esopageal Dysphagia Questionnaire).

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Please contact the study team to discuss whether or not you are eligible to participate in a study.

Inclusion Criteria:

  • Adults ≥ 18

Exclusion Criteria:

  • Children less than 18
  • Prior diagnosis of metastatic malignancy, regardless of location

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Karthik Ravi, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20316214

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