A Study to Predict Sepsis-Associated Acute Kidney Injury by Assessing Renal Microvascular Blood Flow and Elasticity with Contrast-Enhanced Ultrasonography and Ultrasound Elastogram


About this study

The purpose of this study is to assess kidney microcirculation using contrast-enhanced ultrasonography associated with kidney ultrasound elastography among patients who are at risk of sepsis-associated acute kidney injury provides strong predictive ability for AKI and potential therapeutic targets. 


Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Sepsis and septic shock patients who are admitted to mixed ICU at Rochester Campus of Mayo Clinic Hospital, Mayo Clinic, Rochester, Minnesota.

Exclusion Criteria:

  • Not providing informed consent.
  • Patients who are allergic to contrast agent (Lumason).
  • Patients who are known or suspected right-to-left, bi-directional, or transient right-to-left cardiac shunts.
  • Patients who have a history of hypersensitivity reactions to sulfur hexafluoride lipid microsphere components or to any of the inactive ingredients in Lumason.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Kianoush Banaei Kashani, M.D., M.S.

Contact us for the latest status

Contact information:

Kianoush Banaei Kashani M.D., M.S.

(507) 266-7093


More information


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