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Assessing Health Literacy and Diabetes Knowledge in Hospitalized Diabetic Patients
Scottsdale/Phoenix, AZ
The purpose of this study is to identify potentially modifiable barriers to hyperglycemia management in hospitalized diabetic patients. Both general hospitalized diabetic patients and first time renal transplant patients will be studied.
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A Study to Examine the Self-Management of Diabetes
Rochester, MN
The purposes of this study are to determine: (a) if there is a relationship between the extent that the individual mode of human agency is employed and the quality of diabetes control among adults who have been diagnosed with DM2 for at least one year; and (b) if there is a relationship between the extent that the proxy mode of human agency is employed and quality of diabetes control among adults who have been diagnosed with DM2 for at least one year.
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Immune mediated diabetes due to PD 1 inhibitors
Rochester, MN
The purpose of this study is to identify immune mediated diabetes in patients treated with PD 1 inhibitors, and characterizing its clinical course, laboratory features and possible risk factors.
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The International Diabetes Closed Loop Trial DCLP4
Rochester, MN
The purpose of this study is to compare the effectiveness and safety of an automated insulin delivery (AID) study system using a Model Predictive Control (MPC) algorithm versus Sensor Augmented Pump (SAP) (which may or may not include PLGS; to be referred to as SAP) therapy in people with type 1 diabetes. A Pilot Phase involving up to 7 participants using the study system for 10-14 days will be conducted prior to the crossover trial.
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Longitudinal Effects of Diabetes-Associated Variation in TCF7L2 on Glucagon and Insulin Secretion in Non-Diabetic Humans
Rochester, MN
The goal of this study is to determine the role of postprandial glucagon suppression and insulin secretion in the progression of glucose intolerance in people with diabetes-associated variation in TCF7L2.
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Impact of Nutrition Education and Access to Nutritious Foods on Diabetes Control.
Mankato, MN
The purpose of this study is to determine if a 6 month supply (1 meal//day) of healthy food choices readily available in the patients home and self management training including understanding how foods impact diabetes, improved food choices and how to prepare those foods, will improve glucose control, and if there will be lasting behavior change modification after the program.
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A Study to Better Understand the Role of the Hormones Glucagon and Insulin in the Progression of Diabetes
Rochester, MN
The purpose of this study is to determine the longitudinal effect of diabetes-associated variation in TCF7L2 on a-cell function and the contribution of a-cell function to longitudinal glucose tolerance and EGP in non-diabetic subjects.
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PGC-1 & Muscle Mitochondrial Dysfunction in Diabetes
Scottsdale/Phoenix, AZ
The goal of this study is to understand how and why insulin resistant individuals respond differently to exercise as compared with insulin sensitive individuals at the skeletal muscle and gene expression level.
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A Study of Patients with Diabetes Mellitus (DM) Dispose of Hazardous Waste Items
Scottsdale/Phoenix, AZ
The objective of this study is to gain understanding of how patients with diabetes mellitus (DM) dispose of hazardous waste items (e.g., needles, used glucometer strips, unused insulin) with the goal of providing education regarding safe practices
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A Study to Establish a Biobank of Blood Samples to Study the Relationship Between Diabetes Mellitus and Other Pancreatic Conditions
La Crosse, WI; Eau Claire, WI; Rochester, MN
The purpose of this study is to establish a biobank of blood samples to study the relationship between diabetes mellitus and other pancreatic conditions.
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Continuous Glucose Monitoring in Hospitalized Patients with Diabetes Mellitus
Jacksonville, FL
The purpose of this study is to determine if patient’s own Continuous Glucose Monitoring (CGMs) worn in the non-ICU hospital setting have adequate accuracy for blood glucose monitoring when compared to point-of-care capillary glucose measurement, and to determine if alerts given by CGMs worn in the non-ICU hospital would prevent episodes of hyperglycemia and hypoglycemia.
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A Study to Evaluate the Effect of a Medically-tailored Meal Service on Changes in Diabetic Patients' A1c
Jacksonville, FL
Patients age 25 to 75 who are in the care of one of the primary care physicians at Mayo Clinic in Jacksonville, Florida or Montage Health in Monterey, California and have a recent HbA1c in the range of 7.5% to 13% will be prospectively identified and eligible for participation in this randomized, crossover clinical trial examining the effect of medically tailored meal delivery on glycemic control. Eligible patients who sign informed consent will be randomized in a 1:1 fashion to treatment sequence AB or treatment sequence BA. In the first study phase, participants randomized to sequence AB will receive 3 ...
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EPIDEMIOLOGY OF DIABETES INTERVENTIONS AND COMPLICATIONS
Rochester, MN
The purpose of this study is to use the well-characterized Diabetes Control and Complications Trial (DCCT) cohort of 1,400 patients to determine the long-term effects of prior separation of glycemic levels on micro- and macrovascular outcomes.
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A Study to Evaluate the Reapplix 3C Patch® System to Treat Diabetic Foot Ulcers
Scottsdale/Phoenix, AZ
The purpose of this study is to compare incidence rates of complete hard-to-heal diabetic foot ulcer healing in Medicare beneficiaries following application of the 3C Patch® plus usual care (i.e., care consistent with the International Working Group on the Diabetic Foot guidelines), tested against a historical control group of similar patients that received usual care during a randomized controlled trial.
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Ursodiol on Insulin Sensitivity, Gastric Emptying and Body Weight With Type 2 Diabetes on Metformin
Rochester, MN
This study will evaluate whether bile acids are able to increase insulin sensitivity and enhance glycemic control in T2DM patients, as well as exploring the mechanisms that enhance glycemic control. These observations will provide the preliminary data for proposing future therapeutic as well as further mechanistic studies of the role of bile acids in the control of glycemia in T2DM.
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Development of Diabetes Mellitus Type 2 in Stress Hyperglycemia and Control of Known Diabetes Mellitus after Discharge
Rochester, MN
The purpose of this study is to determine if Inpatient Stress Hyperglycemia is an indicator of future risk of developing type 2 Diabetes Mellitus.
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A Study to Evaluate Bio-markers Associated with Improved Glucose Control in Patients with Type 1 Diabetes
Rochester, MN
The purpose of this study is to collect blood samples for biomarker assessment in type 1 diabetes prior to and at specific time points during closed loop control.
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A Study Comparing the Effectiveness and Safety of the Morning Injection of Toujeo versus Lantus in Patients with Type 1 Diabetes Mellitus
Rochester, MN
The purpose of this study is to demonstrate that a morning injection of Toujeo compared to Lantus will provide better glycemic control, as shown by Continuous Glucose Monitoring (CGM), in adult patients with type 1 diabetes mellitus.
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A Study of the Metabolome and Microbiome Following Bariatric Surgery, and the Effect on Metabolism in Patients with Type 2 Diabetes
Rochester, MN
The purpose of this study is to identify changes to the metabolome (range of chemicals produced in the body) and microbiome (intestine microbe environment) that are unique to Roux-en-Y gastric bypass surgery and assess the associated effect on the metabolism of patients with type 2 diabetes.
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Measuring Glucagon Kinetics in Humans
Rochester, MN
Our goal in this pilot study is to test and develop a novel method that will accurately measure, in vivo, glucagon kinetics in healthy humans and generate preliminary data in type 1 diabetes (T1DM) subjects under overnight fasted conditions.
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A Study to Evaluate the Safety and Effectiveness of the Drug TTP399 to Target A1c in Type 2 Diabetics
Rochester, MN
This trial is a multi-center, adaptive, randomized, double-blind, placebo- and active- controlled, parallel group, phase 2 study in subjects with Type 2 Diabetes Mellitus to evaluate the effect of TTP399 on HbA1c following administration for 6 months.
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A Study of the Genetic Links of Type 2 Diabetes in Latino Families
Scottsdale/Phoenix, AZ; Rochester, MN
The purpose of this study is to find the inheritable changes in genetic makeup that are related to the development of type 2 diabetes in Latino families.
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Family Centered Wellness Coaching Program in Patients at High Risk for Developing Diabetes
Rochester, MN
To explore the feasibility of conducting a family centered wellness coaching program for patients at high risk for developing diabetes, in a primary care setting.
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To determine engagement patterns.
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To describe characteristics of families who are likely to participate.
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To identify barriers/limitations to family centered wellness coaching.
To assess whether a family centered 8 week wellness coaching intervention for primary care patients at high risk for diabetes will improve self-care behaviors as measured by self-reported changes in physical activity level and food choices.
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Risk Prediction for Immune Checkpoint Inhibitor Associated Diabetes Mellitus
Rochester, MN
The purpose of this study is to identify risk factors for ICI associated diabetes mellitus and to assess the severity and natural course of this immune related adverse effect.
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Pharmacist Collaboration in the Care of Patients with Diabetes within the Primary Care Clinic Setting
Rochester, MN
The primary aim of this study is to compare the outcome measures of adult ECH type 2 diabetes patients who were referred to onsite pharmacist services for management of their diabetes to similar patients who were not referred for pharmacy service management of their diabetes. A secondary aim of the study is to assess the Kasson providers’ satisfaction level and estimated pharmacy service referral frequency to their patients. A tertiary aim of the study is to compare the hospitalization rates of type 2 diabetes rates who were referred to onsite pharmacist services for management of their diabetes to similar patients ...
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Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.
Rochester, MN
This study is being done to understand metformin's mechanisms of action regarding glucose production, protein metabolism, and mitochondrial function.
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A Study of PDD in Type 2 Diabetes
Rochester, MN
The purpose of this study is to learn more about if the medications, Nesiritide and Entresto, could help the function of the heart and kidneys.
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Stories for Change: Digital Storytelling for Diabetes Self-Management among Hispanic Adults
Rochester, MN
The purpose of this study is to evaluate the impact of a digital storytelling intervention derived through a community-based participatory research (CBPR) approach on type 2 diabetes mellitus (T2D) outcomes among Hispanic adults with poorly controlled type 2 diabetes mellitus (T2D) in primary care settings through a randomized clinical trial.
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A Study to Evaluate Diabetes Management Using Quality of Life, Burden of Treatment, Social Integration and Avoidance of Future Events
Rochester, MN
Can QBSAfe be implemented in a clinical practice setting and improve quality of life, reduce treatment burden and hypoglycemia among older, complex patients with type 2 diabetes?
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Penile Length Restoration in Men with Type II Diabetes
Rochester, MN
The purpose of this study is to assess penile length pre- and post-completion of RestoreX® traction therapy compared to control groups (no treatment) among men with type II diabetes.
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An Imaging Study Measuring the Form and Structure of the Layers of the Duodenum in Patients with and without Type 2 Diabetes
Jacksonville, FL
This observational study is conducted to determine how the duodenal layer thicknesses (mucosa, submucosa, and muscularis) vary with several factors in patients with and without type 2 diabetes.
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Supervised Safety and Feasibility Evaluation of the Zone-MPC Control Algorithm Integrated into the iAPS in Pregnant Patients with Type 1 Diabetes
Rochester, MN
The purpose of this research is to test the safety and effectiveness of the interoperable Artificial Pancreas System Smartphone App (iAPS) in managing blood sugars in pregnant patients with type 1 diabetes.
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Unified Safety System (USS) Virginia Closed-Loop Versus Sensor Augmented Pump Therapy for Oversight Control in Type 1 Diabetes
Rochester, MN
The purpose of this study is to use the USS Virginia Closed-Loop system for overnight insulin delivery in adults with Type 1 Diabetes (T1DM) in an outpatient setting to evaluate the system's ability to significantly improve blood glucose levels. This protocol will test the feasibility of "bedside" closed-loop control - an approach comprised of standard sensor-augmented pump therapy during the day using off-the-shelf devices and overnight closed-loop control using experimental devices in an outpatient setting. The rationale for this study is as follows: we anticipate that closed-loop control may ultimately be adopted by patients with T1DM in a selective manner. ...
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The Work of Being a Patient With Diabetes: Data Collection Via a Smartphone Application
Rochester, MN
This mixed methods study aims to answer the question: "What is the work of being a patient with type 2 diabetes mellitus?" .
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Impact of Non-glucose Signals on Glycemic Control in Patients With Type 1 Diabetes
Rochester, MN
This clinical trial will identify exercise-related and emotional stress related effects on glycemic control in patients with type 1 diabetes using sensor-augmented pump (SAP) therapy.
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Impact of Insulin Antibodies on Glucose Variability
Rochester, MN
The purpose of this study is to evaluate glucose variability in patients with type 1 diabetes (T1D) and insulin antibodies, to evaluate the clinical significance of insulin antibodies, and to establish an in vitro assay that would detect antibodies to insulin and insulin analogs.
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Stories for Change: Digital Storytelling for Diabetes Self-Management Among Somali Adults
Rochester, MN
The purpose of this study is to assess the effectiveness of a digital storytelling intervention derived through a community based participatory research (CBPR) approach on self-management of type 2 diabetes (T2D) among Somali adults.
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A Study to Assess the Effect of Psyllium vs. Wheat Dextrin on Glycemic Control and Inflammatory Markets in Diabetes Mellitus 2
Rochester, MN
The purpose of this study is to assess whether psyllium is more effective in lowering fasting blood sugar and HbA1c, and to evaluate the effect of psyllium compared to wheat dextrin on the following laboratory markers: LDL-C, inflammatory markers such as ceramides and hsCRP, and branch chain amino acids which predict Diabetes Mellitus (DM).
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Effects of Hyperglycemia on Myocardial Perfusion in Humans With and Without Type 2 Diabetes
Rochester, MN
The overall goal of this proposal is to determine the effects of acute hyperglycemia and its modulation by Glucagon-like Peptide-1 (GLP-1) on myocardial perfusion in type 2 diabetes (DM). This study plan utilizes myocardial contrast echocardiography (MCE) to explore a) the effects of acute hyperglycemia on myocardial perfusion and coronary flow reserve in individuals with and without DM; and b) the effects of GLP-1 on myocardial perfusion and coronary flow reserve during euglycemia and hyperglycemia in DM. The investigators will recruit individuals with and without DM matched for age, gender and degree of obesity. The investigators will measure myocardial perfusion ...
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A Comparative Effectiveness Study of Major Glycemia-lowering Medications for Treatment of Type 2 Diabetes
Rochester, MN
The GRADE Study is a pragmatic, unmasked clinical trial that will compare commonly used diabetes medications, when combined with metformin, on glycemia-lowering effectiveness and patient-centered outcomes.
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Study of Critical Outcomes in Pregnant Patients on Insulin Pump with Type 1 Diabetes
Rochester, MN
The purpose of this study is to serve as a comparator group to a group of patients that will be managed with AP for varying periods of time during pregnancy.
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Pilot Study of Between Visit Interaction to Improve Glycemic Control in Pregnancy With Pre-existing Diabetes
Rochester, MN
Hypothesis: Increased contact with the diabetes care team throughout pregnancy will lead to improved glucose control during pregnancy.
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Comparison of Bone Quality in Subjects with or without Type 2 Diabetes
Rochester, MN
The purpose of this study is to test the hypothesis that patients with T2DM will have greater deterioration in BMSi and in cortical porosity over 3 yrs as compared to sex- and age-matched non-diabetic controls; and identify the circulating hormonal (e.g., estradiol [E2], testosterone [T]) and biochemical (e.g., bone turnover markers, AGEs) determinants of changes in these key parameters of bone quality, and evaluate the possible relationship between existing diabetic complications and skeletal deterioration over time in the T2DM patients.
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Natural History of Diabetes after Total Pancreatectomy
Rochester, MN
The purpose of this study is to estimate the risk of diabetes related complications after total pancreatectomy. We will contact long term survivors after total pancreatectomy to obtain data regarding diabetes related end organ complications.
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A Study of Nighttime Blood Sugar Control Patterns in Type 2 Diabetes
Rochester, MN
The purpose of this study is to understand nighttime glucose regulation in humans and find if the pattern is different in people with Type 2 diabetes
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A Study to Evaluate the Effect of Exercise on Type I Diabetes
Rochester, MN
The purpose of this study is to gather preliminary data to better understand acute effects of exercise on glucose metabolism. We will address if subjects with Type 1 Diabetes (T1D) are more insulin sensitive during and following a short bout of exercise compared to healthy controls. We will also determine insulin dependent and insulin independent effects on exercise in people with and without type 1 diabetes.
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Dual-Hormone Control of Post-absorptive and Post-prandial Glucose in Type 1 Diabetes
Rochester, MN
The primary goal of this study protocol is to determine the candidate ratio of pramlintide and insulin co-infusion in individuals with type 1 diabetes (T1DM) to enable stable glucose control during the overnight post-absorptive and in the postprandial periods.
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Crossover Feasibility Study of Portable AP Device with Zone-MPC and HMS and Adapted I:C and Basal Insulin
Rochester, MN
The purpose of this trial is to assess the performance of an Artificial Pancreas (AP) device using the Portable Artificial Pancreas System (pAPS) platform for subjects with type 1 diabetes using an insulin pump and rapid acting insulin. This proposed study is designed to compare closed-loop control with or without optimization of initialization parameters related to basal insulin infusion rates and insulin to carbohydrate (I:C) ratios for meals and snacks. The study consists of an evaluation of the Artificial Pancreas device system during two 24-27.5-hour closed-loop phases in an outpatient/hotel environment. Prior to the closed-loop phases, each subject will undergo ...
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Diabetes Technology Clinic Patient Interviews
Rochester, MN
The study is designed to understand the confidence and competence level of patients with type 1 diabetes mellitus in their ability to make changes to their insulin pump.
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A Study to Compare Model Predictive Control (MPC) Artificial Pancreas vs. Sensor Augmented Pump (SAP)/Predictive Low Glucose Suspend (PLGS) with Different Stress Assessments for Type 1 Diabetes Patients
Rochester, MN
The purpose of this study is to compare the effectiveness and safety of an automated insulin delivery (AID) system using a model predictive control (MPC) algorithm versus Sensor-Augmented Pump/Predictive Low Glucose Suspend (SAP/PLGS) therapy with different stress assessments over a 4-week period.
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A Study to Evaluate the Effect of Hyperoxia on Glucose Metabolism in Type 2 Diabetics
Rochester, MN
The purpose of this study is to evaluate if breathing pure oxygen overnight affects insulin sensitivity in participants with diabetes.
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A Study of the Impact of Decision Aids to Enhance Shared Decision Making for Diabetes
Rochester, MN
The purpose of this study is to determine the impact of patient decision aids compared to usual care on measures of patient involvement in decision-making, diabetes care processes, medication adherence, glycemic and cardiovascular risk factor control, and use of resources in nonurban practices in the Midwestern United States.
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A Study to Assess Glycemic Variability in Hospitalized Type 1 Diabetes Patients
Rochester, MN
The purpose of this study is to assess the glycemic variability in patients with type 1 diabetes admitted in the hospital using a glycemic sensor.
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A Study to See if There is a Connection Between Bad Childhood Experiences and Poor Blood Sugar Control in Patients with Type 1 Diabetes
Rochester, MN
The purpose of this study is to see if there is a connection between bad experiences in the patient's childhood, either by the patient or the parent, and poor blood sugar control, obesity, poor blood lipid levels, and depression in patients with type 1 diabetes.
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Data-Driven Behavioral-Change Interventions to Improve Type 1 Diabetes (TID) Treatment Adherence
Scottsdale/Phoenix, AZ
The purpose of this study is to assess a novel informatics approach that incorporates the use of patient’s diabetes self-care data into the design and delivery of individualized education interventions to improve diabetes control.
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A Study to Evaluate the Effect of Exercise on Type I Diabetes
Rochester, MN
The purpose of this study is to gather preliminary data to better understand acute effects of exercise on glucose metabolism. We will address if subjects with Type 1 Diabetes (T1D) are more insulin sensitive during and following a short bout of exercise compared to healthy controls. We will also determine insulin dependent and insulin independent effects on exercise in people with and without type 1 diabetes.
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Dual-Hormone Control of Post-absorptive and Post-prandial Glucose in Type 1 Diabetes
Rochester, MN
The primary goal of this study protocol is to determine the candidate ratio of pramlintide and insulin co-infusion in individuals with type 1 diabetes (T1DM) to enable stable glucose control during the overnight post-absorptive and in the postprandial periods.
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Diabetes Technology Clinic Patient Interviews
Rochester, MN
The study is designed to understand the confidence and competence level of patients with type 1 diabetes mellitus in their ability to make changes to their insulin pump.
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Effect of High Fat and High Glycemic Diets
Rochester, MN
The investigators will determine whether people with high muscle mitochondrial capacity produce higher amount of reactive oxygen species (ROS) on consuming high fat /high glycemic diet and thus exhibit elevated cellular oxidative damage. The investigators previously found that Asian Indian immigrants have high mitochondrial capacity in spite of severe insulin resistance. Somalians are another new immigrant population with rapidly increasing prevalence of diabetes. Both of these groups traditionally consume low caloric density diets, and the investigators hypothesize that when these groups are exposed to high-calorie Western diets, they exhibit increased oxidative stress, oxidative damage, and insulin resistance. The investigators will ...
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Crossover Feasibility Study of Portable AP Device with Zone-MPC and HMS and Adapted I:C and Basal Insulin
Rochester, MN
The purpose of this trial is to assess the performance of an Artificial Pancreas (AP) device using the Portable Artificial Pancreas System (pAPS) platform for subjects with type 1 diabetes using an insulin pump and rapid acting insulin. This proposed study is designed to compare closed-loop control with or without optimization of initialization parameters related to basal insulin infusion rates and insulin to carbohydrate (I:C) ratios for meals and snacks. The study consists of an evaluation of the Artificial Pancreas device system during two 24-27.5-hour closed-loop phases in an outpatient/hotel environment. Prior to the closed-loop phases, each subject will undergo ...
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A Study to Compare Model Predictive Control (MPC) Artificial Pancreas vs. Sensor Augmented Pump (SAP)/Predictive Low Glucose Suspend (PLGS) with Different Stress Assessments for Type 1 Diabetes Patients
Rochester, MN
The purpose of this study is to compare the effectiveness and safety of an automated insulin delivery (AID) system using a model predictive control (MPC) algorithm versus Sensor-Augmented Pump/Predictive Low Glucose Suspend (SAP/PLGS) therapy with different stress assessments over a 4-week period.
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A Study to Assess Maternal and Fetal Outcomes in Pregnancy with Type 1 Diabetes Mellitus and Controls
Rochester, MN
The purpose of this study is to retrospectively and prospectively compare maternal and fetal/newborn clinical outcomes in age-matched pregnant patients with T1D and healthy controls and to assess the relationship between glycemic variability and pregnancy outcomes in the current era.
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Automated Insulin Delivery in Elderly with Type 1 Diabetes
Rochester, MN
The study is being done to find out if low blood sugar (hypoglycemia) can be reduced in people with type 1 diabetes (T1D) 65 years and older with use of automated insulin delivery (AID) system.
The device systems used in this study are approved by the Food and Drug Administration (FDA) for diabetes management. We will be collecting data about how they are used, how well they work, and how safe they are.
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A Dose-response of the Effects of Exendin-9,39 on GI Symptoms and Food Intake
Rochester, MN
Exendin-(9,39) has been shown to have effects on beta-cell function, and after gastric bypass, to accelerate gastrointestinal transit. - infused at rates of 300pmol/kg/min. Given that gastrointestinal transit is typically delayed by Glucagon-Like Peptide-1 (GLP-1) and also that this hormone causes decreased food intake through increased satiation, it is reasonable to expect an effect of Exendin-9,39 on appetite. This may help explain the effects of gastric bypass on food intake. To examine the effect of Exendin on food intake we propose a dose-response study to determine whether the compound has effects in a dose-dependent fashion. We will examine the presence ...
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Effect of TAK-954 on Gastrointestinal and Colonic Transit in Diabetic or Idiopathic Gastroparesis Participants
Rochester, MN
The purpose of this study is to evaluate the dose-dependent effects of TAK-954 on gastric emptying time of solids in participants with diabetic or idiopathic gastroparesis assessed by scintigraphy.
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Gastrointestinal Sensorimotor Dysfunctions in Diabetes Mellitus
Rochester, MN
To understand why patients with indigestion with or without diabetes have gastrointestinal symptoms and in particular to understand where the symptoms are related to increased sensitivity to nutrients.
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A Study to Evaluate the Effectiveness and Safety of Exenatide SR for Diabetes Prevention Following Kidney Transplantation
Rochester, MN; Scottsdale/Phoenix, AZ; Jacksonville, FL
The purpose of this study is to compare the rate of progression from prediabetes at 4 months to frank diabetes at 12 months (as defined by increase in HbA1C or fasting BS to diabetic range based on the ADA criteria) after transplantation in kidney transplant recipients on Exenatide SR + SOC vs. standard-of-care alone.
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A Study of Continuous Glucose Monitoring in Individuals 60 Years Old or Older with Type 1 Diabetes
Rochester, MN
The primary objective of this study is to determine if continuous glucose monitoring (CGM) can reduce hypoglycemia and improve quality of life in older adults with type 1 diabetes (T1D).
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Safety and Efficacy of EndoBarrier in Subjects With Type 2 Diabetes Who Are Obese
Scottsdale/Phoenix, AZ; Rochester, MN
To determine if the EndoBarrier safely and effectively improves glycemic control in obese subjects with type 2 diabetes.
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A Study to Evaluate the Impact of Nutrition Education and Access to Nutritious Foods on Diabetes Control
Mankato, MN
The purpose of this study is to evaluate whether or not a 6 month supply (1 meal//day) of healthy food choices readily available in the patient's home and self management training including understanding of how foods impact diabetes, improved food choices and how to prepare those foods, improve glucose control. In addition, it will evaluate whether or not there will be lasting behavior change modification after the program.
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A Study to Evaluate the Effectiveness and Safety of TAK-906 in Adult Participants With Symptomatic Idiopathic or Diabetic Gastroparesis
Jacksonville, FL
The purpose of this study is to assess the effectiveness and safety of treatment with various dose levels of TAK-906 in adult participants with gastroparesis compared with placebo during 12 weeks of treatment.
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Feasibility Study for a Web Based Health Coaching Program
Rochester, MN
This study is designed to compare an intensive lifestyle and activity coaching program ("Sessions") to usual care for diabetic patients who are sedentary. The question to be answered is whether the Sessions program improves clinical or patient centric outcomes. Recruitment is through invitiation only.
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A Study to Evaluate the Effect of Improving Glycemic Control on Gastric Emptying in Type 1 and Type 2 Diabetes Mellitus
Rochester, MN
The purpose of this study is to evaluate the effects of improving glycemic control, and/or reducing glycemic variability on gastric emptying, intestinal barrier function, autonomic nerve functions, and epigenetic changes in subjects with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) who are switched to intensive insulin therapy as part of clinical practice.
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Shared Decision Making with Diabetic Patients
Rochester, MN
This research study is being done to develop educational materials that will help patients and clinicians talk about diabetes treatment and management options.
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Mediators of insulin resistance in women with a history of gestational diabetes mellitus
Rochester, MN
Women with gestational diabetes mellitus (GDM) are likely to have insulin resistance that persists long after pregnancy, resulting in greater risk of developing type 2 diabetes mellitus (T2DM). The study will compare women with and without a previous diagnosis of GDM to determine if women with a history of GDM have abnormal fatty acid metabolism, specifically impaired adipose tissue lipolysis. The study will aim to determine whether women with a history of GDM have impaired pancreatic β-cell function. The study will determine whether women with a history of GDM have tissue specific defects in insulin action, and also identify the effect of a ...
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Plasma Triglyceride Extraction by the Muscle
Scottsdale/Phoenix, AZ
Increased accumulation of fat into the muscles is associated with what is called insulin-resistant state, which is a pre-diabetic state. The purpose of this research is to find out how fat circulating in the blood following fat consumption is taken up by the muscles in healthy people as well as people that are insulin-resistant. The investigators are specifically interested in how a hormone called insulin is involved in this process. Findings from this research will contribute to our understanding of why insulin-resistant people have increased accumulation of fat in their muscles, and ultimately help to design appropriate interventions to prevent ...
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A Study to Evaluate Copeptin as a Biomarker for Central Diabetes Insipidus Development Following Pituitary Surgery
Rochester, MN
The purpose of this study is to investigate if a blood test measuring copeptin within 24 hours following pituitary surgery could predict development of diabetes insipidus (increased urination and thirst with fluid balance problems) as opposed to the clinical methods we currently use.
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Analysis of Biomarkers in Type 1 Diabetes Mellitus
Rochester, MN
The purpose of this study is to develop a better blood test to diagnose early kidney injury in type 1 diabetes.
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A Study to Evaluate Proinsulin and Glucagon Secretion in Postpartum Women with and without Gestational Diabetes
Rochester, MN
The purpose of this study is to determine the changes in tissue function that occur in the first year postpartum in women with and without gestational diabetes mellitus.
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A Study of the Relationship of Markers of Cellular Senescence to Skeletal Parameters in Type 2 Diabetes Mellitus
Rochester, MN
The purpose of this study is to test whether markers of cellular aging and the SASP are elevated in subjects with obesity and further increased in patients with obesity and Type 2 Diabetes Mellitus (T2DM) and to relate markers of cellular aging (senescence) and the SASP to skeletal parameters (DXA, HRpQCT, bone turnover markers) in each of these groups.
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Addressing Diabetes Together
Rochester, MN
Integration of Diabetes Prevention Program (DPP) and Diabetes Self Management Program (DSMP) into WellConnect.
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A Study of the Effect of Colesevelam on Glucose Metabolism in Patients with Type 2 Diabetes
Rochester, MN
The purpose of this study is to determine the metabolic effects of Colesevelam, particularly for the ability to lower blood sugar after a meal in type 2 diabetics, in order to develop a better understanding of it's potential role in the treatment of obesity.
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Muscle Metabolism Characteristics Related to Diabetes-Related Conditions
Rochester, MN
Muscle insulin resistance is a hallmark of upper body obesity (UBO) and Type 2 diabetes (T2DM), whereas lower body obesity (LBO) is characterized by near-normal insulin sensitivity. It is unknown whether muscle free fatty acid (FFA) availability or intramyocellular fatty acid trafficking differs between different obesity phenotypes. Likewise, we do not understand to what extent the incorporation of FFA into ceramides or diacylglycerols (DG) affect insulin signaling and muscle glucose uptake. By measuring muscle FFA storage into intramyocellular triglyceride, intramyocellular fatty acid trafficking, activation of the insulin signaling pathway and glucose disposal rates we will provide the first integrated examination ...
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Podocyturia in Diabetes Mellitus Type 2 and Proteinuric Glomerulonephritides
Rochester, MN
The goal of this study is to evaluate the presence of podocytes (special cells in the kidney that prevent protein loss) in the urine in patients with diabetes or glomerulonephritis (inflammation in the kidneys). Loss of podocyte in the urine may be an earlier sign of kidney injury (before protein loss) and the goal of this study is to evaluate the association between protein in the urine and podocytes in the urine.
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A Study to Evaluate the Effects of Niacin on FFA in UBO and T2DM in Insulin Resistant States
Rochester, MN
Muscle insulin resistance is a hallmark of upper body obesity (UBO) and Type 2 diabetes (T2DM). It is unknown whether muscle free fatty acid (FFA) availability or intramyocellular fatty acid trafficking is responsible for the abnormal response to insulin. Likewise, we do not understand to what extent the incorporation of FFA into ceramides or diacylglycerols (DG) affect insulin signaling and muscle glucose uptake. We will measure muscle FFA storage into intramyocellular triglyceride, intramyocellular fatty acid trafficking, activation of the insulin signaling pathway and glucose disposal rates under both saline control (high overnight FFA) and after an overnight infusion of intravenous ...
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A Study of the Effects of Inflammation on Fat Tissue and Insulin in People with Different Body Shapes
Rochester, MN
The purpose of this study is to see why the ability of fat cells to respond to insulin is different depending on body shape and how fat tissue inflammation is involved.
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A Study Comparing the Effect of Niacin and Insulin on Splanchnic Bed Fatty Acid Spillover
Rochester, MN
The purpose of this study is to learn more about how the body stores dietary fat. Medical research has shown that fat stored in different parts of the body can affect the risk for diabetes, heart disease and other major health conditions.
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A Study of Adjustable Gastric Banding and Its Effects on After Meal Glucose Metabolism, Independent of Weight Loss
Rochester, MN
The purpose of this study is to determine the mechanism(s) by which common bariatric surgical procedures alter carbohydrate metabolism. Understanding these mechanisms may ultimately lead to the development of new interventions for the prevention and treatment of type 2 diabetes and obesity.
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A Study of The International Diabetes Closed Loop (iDCL) Trial: Clinical Acceptance of the Artificial Pancreas (DCLP3 Extension)
Rochester, MN
The purpose of this 3-month extension study (DCLP3 Extension) following a primary trial (DCLP3 or NCT03563313) to assess effectiveness and safety of a closed loop system (t:slim X2 with Control-IQ Technology) in a large randomized controlled trial.
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A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis 01
Jacksonville, FL
The purpose of this study is to evaluate the safety and effectiveness of Relamorelin compared to placebo in patients with diabetic gastroparesis.
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Patient-Derived Stem Cell Therapy for Diabetic Kidney Disease
Rochester, MN
The purpose of this study is to assess the safety and tolerability of intra-arterially delivered mesenchymal stem/stromal cells (MSC) to a single kidney in one of two fixed doses at two time points in patients with progressive diabetic kidney disease.
Diabetic kidney disease, also known as diabetic nephropathy, is the most common cause of chronic kidney disease and end-stage kidney failure requiring dialysis or kidney transplantation. Regenerative, cell-based therapy applying MSCs holds promise to delay the progression of kidney disease in individuals with diabetes mellitus. Our clinical trial will use MSCs processed from each study participant to test the ...
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The International Diabetes Closed Loop (iDCL) Trial: Clinical Acceptance of the Artificial Pancreas
Rochester, MN
The objective of the study is to assess efficacy and safety of a closed loop system (t:slim X2 with Control-IQ Technology) in a large randomized controlled trial.
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A Study of Pancreatic Polypeptide Response in Patients with Diabetes Mellitus with and without Pancreatic Cancer
Rochester, MN
The purpose of this study is to determine if a blood test called "pancreatic polypeptide" can help distinguish between patients with diabetes mellitus with and without pancreatic cancer.
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The International Diabetes Closed Loop (iDCL) Trial: Protocol 1
Rochester, MN
The objective of the study is to assess the efficacy and safety of home use of a Control-to-Range (CTR) closed-loop (CL) system.
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Pyridorin in Diabetic Nephropathy
Scottsdale/Phoenix, AZ
The purpose of this study is to evaluate the safety and efficacy of oral Pyridorin 300 mg BID in reducing the rate of progression of nephropathy due to type 2 diabetes mellitus.
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Examination of the Pancreas in New-onset Diabetes
Rochester, MN
The purpose of this study is to create a prospective cohort of subjects with increased probability of being diagnosed with pancreatic cancer and then screen this cohort for pancreatic cancer
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Multi-center Trial in Adult and Pediatric Patients With Type 1 Diabetes Using Hybrid Closed Loop System at Home
Rochester, MN
The purpose of this study is to demonstrate the safety and effectiveness of the Hybrid Closed Loop system (HCL) in adult and pediatric patients with type 1 diabetes in the home setting. A diverse population of patients with type 1 diabetes will be studied. The study population will have a large range for duration of diabetes and glycemic control, as measured by glycosylated hemoglobin (A1C). They will be enrolled in the study regardless of their prior diabetes regimen, including using Multiple Daily Injections (MDI), Continuous Subcutaneous Insulin Infusion (CSII) or Sensor-Augmented Pump therapy (SAP)
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A Study to Identify Genetic Risk Determinants in Families with High Penetrance Type 1 Diabetes
Rochester, MN
The purpose of this study is to identify novel genetic variants that predispose to Type 1 Diabetes.
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A Study to Evaluate the Safety and Effectiveness of RM-131 Administered to Patients with Vomiting Symptoms and Moderate to Severe Diabetes Caused Paralysis of the Stomach
Rochester, MN
The purpose of this study is to evaluate the effects of multiple dose regimens of RM-131 on vomiting episodes, stomach emptying and stomach paralysis symptoms in patients with Type 1 and Type 2 diabetes and gastroparesis.
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Anti-VEGF vs. Prompt Vitrectomy for VH From PDR
Rochester, MN
Although vitreous hemorrhage (VH) from proliferative diabetic retinopathy (PDR) can cause acute and dramatic vision loss for patients with diabetes, there is no current, evidence-based clinical guidance as to what treatment method is most likely to provide the best visual outcomes once intervention is desired. Intravitreous anti-vascular endothelial growth factor (anti-VEGF) therapy alone or vitrectomy combined with intraoperative PRP each provide the opportunity to stabilize or regress retinal neovascularization. However, clinical trials are lacking to elucidate the relative time frame of visual recovery or final visual outcome in prompt vitrectomy compared with initial anti-VEGF treatment. The Diabetic Retinopathy Clinical Research ...
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Insulin Deprivation on Brain Structure and Function in Humans With Type 1 Diabetes
Rochester, MN
What are the effects of transient insulin deprivation on brain structure, blood flow, mitochondrial function, and cognitive function in T1DM patients? What are the effects of transient insulin deprivation on circulating exosomes and metabolites in T1DM patients?
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A Study to Assess Bone Quality Characteristics, Comparing Type 2 Diabetes Patients who have or have not had Prior Fragile Bone Fractures
Rochester, MN
The purpose of this study is to assess key characteristics of bone quality, specifically material strength and porosity, in patients who have type 2 diabetes. These patients are at an unexplained increased risk for fractures and there is an urgent need to refine clinical assessment for this risk.
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Medtronic study with Personalized Closed Loop
Rochester, MN
The purpose of this study is to collect device data to assist in the development of a Personalized Closed Loop (PCL) system.
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A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Exploratory Effectiveness of Nimacimab in Patients With Diabetic Gastroparesis
Rochester, MN
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and exploratory effectiveness of nimacimab in patients with diabetic gastroparesis.
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A Study to Evaluate the Effects of Ondansetron on Gastrointestinal Sensorimotor Dysfunctions in Diabetes Mellitus and Dyspepsia
Rochester, MN
The purpose of this study is to understand why patients with indigestion, with or without diabetes, have gastrointestinal symptoms and, in particular, to understand where the symptoms are related to increased sensitivity to nutrients.Subsequently, look at the effects of Ondansetron on these patients' symptoms.
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Trial of IW-9179 in Patients With Diabetic Gastroparesis (DGP)
Rochester, MN
The objectives of this study are to evaluate the safety of IW-9179 in patients with diabetic gastroparesis (DGP) and the effect of treatment on the cardinal symptoms of DGP.
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A Study Assessing the Impact of a Whole Food Plant-Based Diet for Diabetic Patients Who are Undergoing a Total Joint Replacement
Scottsdale/Phoenix, AZ
The purpose of this study is to assess the impact of a whole food plant-based diet on blood sugar control in diabetic patients versus a control group on the American Diabetics Association diet before having a total hip, knee, or shoulder replacement surgery.
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A Study to Determine the Impact of Patient-Centered Education and the Use of Digital Photography for Evaluating Adherence with Routine Foot Care and Decrease the Occurrence and Severity of Foot Ulcerations in High-Risk Diabetic Foot Patients
Scottsdale/Phoenix, AZ
The purpose of this study is to look at the relationship of patient-centered education, the Electronic Medical Record (patient portal) and the use of digital photography to improve the practice of routine foot care and reduce the number of foot ulcers/wounds in patients with diabetes.
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Evaluation of a Mixed Meal Test for Diagnosis and Characterization of Type 3c diabeTes Mellitus Secondary to Pancreatic Cancer and Chronic Pancreatitis
Rochester, MN
Diabetes mellitus is a common condition which is defined by persistently high blood sugar levels. This is a frequent problem that is most commonly due to type 2 diabetes. However, it is now recognized that a small portion of the population with diabetes have an underlying problem with their pancreas, such as chronic pancreatitis or pancreatic cancer, as the cause of their diabetes. Currently, there is no test to identify the small number of patients who have diabetes caused by a primary problem with their pancreas.
The goal of this study is to develop a test to distinguish these ...
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A Prospective Study to Establish a New Onset Hyperglycemia and Diabetes (NOD) Cohort
Eau Claire, WI; Rochester, MN; Mankato, MN; La Crosse, WI
The purpose of this study is to prospectively assemble a cohort of subjects >50 and ≤85 years of age with New-onset Diabetes (NOD):
- Estimate the probability of pancreatic ductal adenocarcinoma (PDAC) in the NOD Cohort;
- Establish a biobank of clinically annotated biospecimens including a reference set of biospecimens from pre-symptomatic PDAC and control new-onset type 2 diabetes mellitus (DM) subjects;
- Facilitate validation of emerging tests for identifying NOD subjects at high risk for having PDAC using the reference set; and
- Provide a platform for development of an interventional protocol for early detection of sporadic PDAC ...
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Dietary Interventions in Prediabetes
Rochester, MN
Assessment of glucose metabolism and liver fat after 12 week dietary intervention in pre diabetes subjects. Subjects will be randomized to either high fat (olive oil supplemented),high carb/high fiber (beans supplemented) and high carb/low fiber diets. Glucose metabolism will be assessed by labeled oral glucose tolerance test and liver fat by magnetic resonance spectroscopy pre randomization and at 8 and 12 week after starting dietary intervention.
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Ox Bile- Conjugated Bile Acids Sodium in Type II Diabetes Mellitus
Rochester, MN
To study the effect of an ileocolonic formulation of ox bile extract on insulin sensitivity, postprandial glycemia and incretin levels, gastric emptying, body weight and fasting serum FGF-19 (fibroblast growth factor) levels in overweight or obese type 2 diabetic subjects on therapy with DPP4 (dipeptidyl peptidase-4) inhibitors (e.g. sitagliptin) alone or in combination with metformin.
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A Study to Evaluate the Effectiveness and Safety of D-PLEX in the Prevention of Sternal Infection Post- Cardiac Surgery
Rochester, MN
The purpose of this study is to assess the effectiveness and safety of D-PLEX administered concomitantly over a period of 90 days (3 months)with the standard of care (SOC) IV prophylactic antibiotic treatment vs. SOC in prevention of post-cardiac surgery sternal infections.
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The Contribution of Incretin Hormones to the Amelioration of Glucose Metabolism After Roux-en-Y Gastric Bypass
Rochester, MN
The study is being undertaken to understand how a gastric bypass can affect a subject's diabetes even prior to their losing significant amounts of weight. The hypothesis of this study is that increased glucagon-like peptide-1 (GLP-1) secretion explains the amelioration in insulin secretion after Roux-en-Y Gastric Bypass (RYGB) surgery.
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Dapagliflozin in Type 2 Diabetes or Pre-diabetes, and PRESERVED Ejection Fraction Heart Failure
Rochester, MN
The primary purpose of this study is to evaluate the impact of dapagliflozin, as compared with placebo, on heart failure, disease specific biomarkers, symptoms, health status and quality of life in patients with type 2 diabetes or prediabetes and chronic heart failure with preserved systolic function.
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A Study to Evaluate the Performance of an Advanced Algorithm with CGM in Adults, Adolescents, and Pediatrics
Rochester, MN
The purpose of this study is to demonstrate the performance of the Guardian™ Sensor (3) with an advanced algorithm in subjects age 2 - 80 years, for the span of 170 hours (7 days).
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A Study to Evaluate How Semaglutide Works Compared to Placebo in People with Type 2 Diabetes and Chronic Kidney Disease
Rochester, MN
The purpose of this study is to evaluate whether or not semaglutide can slow down the growth and worsening of chronic kidney disease in people with type 2 diabetes. Participants will receive semaglutide (active medicine) or placebo ('dummy medicine'). This is known as participants' study medicine - which treatment participants get is decided by chance. Semaglutide is a medicine, doctors can prescribe in some countries for the treatment of type 2 diabetes. Participants will get the study medicine in a pen. Participants will use the pen to inject the medicine in a skin fold once a week. The study will close when ...
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Molecular Regulation of Muscle Glucose Metabolism
Scottsdale/Phoenix, AZ
This protocol is being conducted to determine the mechanisms responsible for insulin resistance, obesity and type 2 diabetes.
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Health Benefits of Pulsed Electromagnetic Field Therapy using Bioboosti
Scottsdale/Phoenix, AZ
While the potential clinical uses of pulsed electromagnetic field therapy (PEMF) are extensive, we are focusing on the potential benefits of PEMF on vascular health. We are targeting, the pre diabetic - metabolic syndrome population, a group with high prevalence in the American population. This population tends to be overweight, low fitness, high blood pressure, high triglycerides and borderline high blood glucose.
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Shared Decision Making With Pharmaceutical Care
Rochester, MN
A research study to enhance clinical discussion between patients and pharmacists using a shared decision making tool for type 2 diabetes or usual care.
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A Study to Evaluate the Therapeutic Effectiveness of Rifaximin in Diabetic Gastroparesis Patients Using Bloating as the Primary Endpoint
Jacksonville, FL
The primary purpose of this study is to prospectively assess symptoms of bloating (severity, prevalence) in patients with diabetic gastroparesis.
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Treatment burden, stress, and coping in the context of social distancing: A qualitative study of patients with diabetes mellitus
Rochester, MN
The purpose of this study is to track the treatment burden experienced by patients living with Type 2 Diabetes Mellitus (T2DM) experience as they work to manage their illness in the context of social distancing measures.
To promote social distancing during the COVID-19 pandemic, health care institutions around the world have rapidly expanded their use of telemedicine to replace in-office appointments where possible.1 For patients with diabetes, who spend considerable time and energy engaging with various components of the health care system,2,3 this unexpected and abrupt transition to virtual health care may signal significant changes to ...
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Stories for Change: Digital Storytelling as a Tool for Engagement in Facilitated Discussion for Diabetes
Rochester, MN
The goal of this study is to evaluate a new format for delivery of a culturally tailored digital storytelling intervention by incorporating a facilitated group discussion following the videos, for management of type II diabetes in Latino communities.
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A Study of the Effects of a Nocturnal Rise in Cortisol on Glucose Production in Type 2 Diabetes
Rochester, MN
The purpose of this study is to assess the effects of a nighttime rise in cortisol on the body's glucose production in type 2 diabetes.
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Inflammation and Stem Cells in Diabetic and Chronic Kidney Disease
Rochester, MN
As the global epidemic of obesity and diabetes mellitus spreads, an exponential rise in incident chronic kidney disease (CKD) complicated by end stage renal disease (ESRD) is predicted, leaving healthcare systems overwhelmed worldwide. Hence, there is urgent need for novel therapies to slow the progression of DKD and optimize the health of this patient population. The purpose of this study is to examine the effect of a supplement on mesenchymal stem cells, physical body function (or frailty), kidney function, and total clearance of senescent cells in individuals with CKD. At present, we are enrolling participants with CKD, with a subset ...
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Multicenter Automatic Defibrillator Implantation Trial With Subcutaneous Implantable Cardioverter Defibrillator
Scottsdale/Phoenix, AZ
The MADIT S-ICD trial is designed to evaluate if subjects with a prior myocardial infarction, diabetes mellitus and a relatively preserved ejection fraction of 36-50% will have a survival benefit from receiving a subcutaneous implantable cardioverter defibrillator (S-ICD) when compared to those receiving conventional medical therapy.
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A Study of Immune Cell Abnormalities Found in Individual Patients who have Type 1 Diabetes and are Waiting for Pancreas or Pancreas/Kidney Transplant Surgery
Rochester, MN
The purpose of this study is to measure and characterize specific immune cell abnormalities found in patients who have type 1 diabetes and are on the waiting list for either a pancreas alone or a pancreas and kidney transplant.
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A Study to Evaluate the Effectiveness and Safety of Aramchol Versus Placebo in Subjects With NASH (ARMOR)
Rochester, MN
The purpose of this study is to evaluate the effect of Aramchol as compared to placebo on NASH resolution, fibrosis improvement and clinical outcomes related to progression of liver disease (fibrosis stages 2-3 who are overweight or obese and have prediabetes or type 2 diabetes).
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A Study to Assess Screening for Diabetic Retinopathy Using Retinal Camera in Family Medicine Clinic
Jacksonville, FL
The purpose of this study is to evaluate the ability of appropriately-trained family physicians to screen for and identify Diabetic Retinopathy using retinal camera and, secondarily, to describe patients’ perception of the convenience and cost-effectiveness of retinal imaging.
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A Study of the Adolescent Perception of Living with Type 1 Diabetes
Rochester, MN
The purpose of this study is gain the adolescent perspective on living with type 1 diabetes.
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A Study of the Measurement of Blood Sugar Variation in Type 1 Diabetic Children, and Finding the Causes
Rochester, MN
The purpose of this study is to use multiple devices to measure blood sugar changes and the reasons for these changes in healthy and diabetic children.
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Study to Assess Painful Diabetic Peripheral Neuropathy After High-frequency Spinal Cord Stimulation
Rochester, MN
The purpose of this study is to assess painful diabetic peripheral neuropathy after high-frequency spinal cord stimulation.
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A Study of the Effect of Dapagliflozin on Symptoms and Biomarkers in Diabetes Patients with Heart Failure
Rochester, MN
The primary purpose of this study is to evaluate the impact of dapagliflozin, as compared with placebo, on heart failure disease-specific biomarkers, symptoms, health status, and quality of life in patients who have type 2 diabetes and chronic heart failure with reduced systolic function.
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A Study to Understand the day-to-day Variability in Stomach Emptying and Gastrointestinal (GI) Transit in Patients with Digestive Symptoms
Rochester, MN
The purpose of this study is to understand the day-to-day variability in stomach emptying and gastrointestinal (GI) transit in patients with digestive symptoms. This information will be useful for interpreting the results of stomach emptying studies in future.
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Determinants of Diabetic Nephropathy in American Indians
Scottsdale/Phoenix, AZ
The purpose of this study is to examine the evolution of diabetic kindey injury over an extended period in a group of subjects who previously completed a clinical trial which assessed the ability of losartan to protect the kidney from injury in early diabetic kidney disease. We will also explore the relationship between diabetic kidney disease and other diabetes complications, including neuropathy and retinopathy.
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A Study to Assess Educational Needs and Perceived Barriers to Care Among Individuals with Chronic Health Conditions and Their Caregivers
Rochester, MN
The purpose of this study is to assess educational needs and barriers to care in both patients with cancer and other serious chronic conditions, as well as their caregivers.