Circulating Angiogenic Cells and Diabetic Vascular Disease


About this study

This study is being done to determine the roles that several molecules play in the repair of injured cells that line your blood vessels.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Healthy subjects (fasting plasma glucose <100 mg/dL, two-hour glucose during the 75-g OGTT <140 mg/dL, and A1C <5.7%)
  • Non-smokers and non-obese (BMI£28),
  • Males/females (18-45 years old).
  • Candidates will be free of systemic diseases and conditions known to affect vascular or endothelial function (i.e. hypertension, hypercholesterolemia, coronary artery disease, cancer, inflammatory disease, or smoking).
  • T1DM patients will be non-smoker, free of complications (such as retinopathy, nephropathy, neuropathy, coronary heart disease, and hypertension).

Exclusion Criteria: 

  • Candidates will be considered ineligible if they have active infection, trauma, or exposure to any invasive
  • medical procedures within 2 weeks before collecting blood.
  • The subjects who have medications including “over-the-counter” medications within 2 weeks before collecting blood, will also be excluded (diabetic subjects
  • will be treated with prescribed medications only).
  • Subjects will be asked to refrain from caffeine on the day of the study visit and also refrain from alcohol use on the day before the study visit and the day of the visit. 
  • Subjects will also be asked to fast for 8 hours before they come in for the blood draw.
  • All female subjects must
  • have a negative pregnancy test in order to participate in the study. 
  • Subjects who are breast-feeding will be excluded. 


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Zvonimir Katusic, M.D., Ph.D.

Closed for enrollment

More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


Mayo Clinic Footer