A Study to Assess Glycemic Variability and Fluctuations in Cognitive Status in Adults with Type 1 Diabetes

Overview

About this study

The objective for thisstudy is to characterize the impact of glycemic excursions on cognition in Type 1 Diabetes (T1D) and determine mediators and moderators of this relationship. This study will allow us to determine how glycemic excursions impact cognition, as well as to identify mediators and moderators of this relationship that could lead to novel interventions.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Aged ≥ 18 years of age.
  • Clinical diagnosis of insulin dependent presumed autoimmune type 1 diabetes by the site investigator.
  • Disease duration of > 1 year.
  • Fluent in English (capable of consenting to the study and following task instructions in English).
  • Participant understands the ecological momentary assessment and agrees to comply with it to the best of their ability.
  • Has 24-hour access to a smart phone with reliable internet access.

Exclusion Criteria:

  • Individuals < 18 years of age.
  • Unable to complete cognitive assessments due to significant visual, motor or hearing impairment.
  • Any medical or psychiatric condition or treatment (via clinic medical records) that is judged by the PIs to interfere with the completion of the study (e.g., active dialysis or chemotherapy, recent myocardial infarction, inpatient psychiatric admission, organ transplant, acute neurological insult, terminal medical condition).
  • Clinical diagnosis of dementia based on clinic medical record data.
  • Current use of real-time continuous glucose monitoring.
  • Unable to complete EMA assessments between 9am – 9pm through the study period (e.g., night shift work, planned travel across time zones, or occupation that does not reliably allow breaks to complete assessments within a reasonable period; e.g., within an hour).

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Yogish Kudva, M.B.B.S.

Open for enrollment

Contact information:

Corey Reid B.S.

(507) 255-0316

Reid.Corey@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20509064

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