A Study to Evaluate Pneumococcal Polysaccharide Vaccine Effectiveness in Children with Type 1 Diabetes

Overview

About this study

Diabetics are at risk for invasive pneumococcal infections and are more likely to have severe outcomes with infection compared to the general population. The pneumococcal (PPSV23) vaccination is recommended for all people with type 1 diabetes, but whether the vaccine is beneficial for this population has not been established.  The purpose of this study is to determine if children with type 1 diabetes have adequate immune response to the PPSV23 vaccination and to assess factors affecting immune response through a pre and post vaccination blood sample.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Children ages 3-18 years old.
  • Clinical diagnosis of Type 1 diabetes.

Exclusion Criteria: 

  • Newly diagnosed with Type 1 diabetes within the past month of study date.
  • Contraindications to receiving 23 valent pneumococcal vaccines.
  • Other conditions associated with compromised immunity and vaccine response.
  • Primary or Secondary Immune deficiency.
  • Previous receipt of PPSV-23 vaccination.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Ana Creo, M.D.

Closed-enrolling by invitation

What is this? (?)
"Close"
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Taylor Cronen B.S.

(507) 293-6835

cronen.taylor@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

.
CLS-20509822

Mayo Clinic Footer