Extracellular Vesicle Cargo in Obesity and Type 2 Diabetes


About this study

The objectives of this study are to identify circulating extracellular vesicle (EV)-derived protein and RNA signatures associated with Type 2 Diabetes (T2D), and to identify changes in circulating EV cargo in patients whose T2D resolves after sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adults age ≥ 21 years.
  • Enrolled in the Bariatric Surgery Program.
  • Patients with A1c of 6.5 or higher within the last 6 months. OR
  • Patients with A1c less than 6.5; have diagnosis of stable type 2 diabetes for > 6 months.

Exclusion Criteria:

  • Individuals < 21 years of age.
  • Disqualified for Bariatric Surgery.
  • BMI < 35 kg/m^2.

Eligibility last updated 8/29/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Michael Edwards, M.D.

Closed-enrolling by invitation

What is this? (?)
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Mauricia Buchanan R.N.


More information


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