A Study of Adjustable Gastric Banding and Its Effects on After Meal Glucose Metabolism, Independent of Weight Loss


About this study

The purpose of this study is to determine the mechanism(s) by which common bariatric surgical procedures alter carbohydrate metabolism. Understanding these mechanisms may ultimately lead to the development of new interventions for the prevention and treatment of type 2 diabetes and obesity.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Age 30 - 65 years
  • Was seen in the Nutrition Clinic at the Mayo Clinic
  • Potentially eligible to undergo adjustable gastric banding
  • Has had a fasting glucose concentration of 126 mg/dl on two or more occasions or has a history of type 2 diabetes treated with one or two oral agents other than thiazolidinediones
  • Willing to be screened at the Mayo Clinic Clinical Research Unit (CRU)
  • Equal number of controls, also with type 2 diabetes from the Nutrition Clinic, who are not interested in pursuing surgical intervention
    • The groups will be matched for age, gender and BMI
    • Duration and severity of diabetes (HbA1c and number of oral medications needed to achieve glycemic control)

Exclusion Criteria

  • Less than 30 years of age
  • On insulin (to minimize the possibility of type 1 diabetes)
  • Older than age 65 years (to minimize the potential confounding effects of age on glucose tolerance)
  • Has no known active systemic illness 
  • No history of microvascular or macrovascular complications of diabetes

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Adrian Vella, M.D.

Closed for enrollment

More information


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