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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 31-40 of 122 for knee

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  1. A Study to Evaluate the Use of Pharmacogenomics in the Perioperative Period to Guide Drug Therapy in Patients Undergoing Total Knee Arthroscopy

    Scottsdale/Phoenix, AZ

  2. A Study to Evaluate NextScience® Xperience™ versus Normal Saline Irrigation Solution for Decreasing Bioburden After Primary Total Hip and Knee Arthroplasty

    Jacksonville, FL

  3. A Study to Evaluate Wearable Biofeedback Sleeve for Injury Prevention and Rehabilitation of Traumatic Knee Injury

    Minneapolis, MN, Rochester, MN

  4. Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement

    Rochester, MN

  5. Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement

    Scottsdale/Phoenix, AZ

  6. Regional Prophylactic Vancomycin With Restricted Tourniquet Time in Primary Total Knee Replacement

    Scottsdale/Phoenix, AZ

  7. Arthroscopic Partial Meniscectomy in OA: A 12-Year Follow-Up

    Rochester, MN

  8. Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections for Knee Osteoarthritis

    Rochester, MN

  9. Ultrasound Guided vs Unguided Intra-articular Knee Injections

    Rochester, MN

  10. A Study to Compare Pain Protocol With and Without Opioids Following Total Joint Arthroplasty

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