Ultrasound Guided vs Unguided Intra-articular Knee Injections


About this study

To determine the accuracy of unguided versus ultrasound (US) guided knee joint injections in obese patients with no clinically detectable effusion.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • BMI > 30
  • No clinically detectable knee effusion
  • Clinical or radiographic evidence of knee osteoarthritis or inflammatory arthritis
  • Must be referred to the Pain Clinic for treatment

Exclusion Criteria

  • History of surgery on the affected knee
  • Evidence of untreated systemic infection or systemic immunocompromise
  • Evidence of cutaneous infections near the study knee injection site
  • Patients on warfarin with an INR > 3.0
  • Patients on oral antiplatelet or anticoagulant medications will be excluded if they have documented evidence of renal insufficiency (GFR < 60)
  • History of iodinated contrast allergy or significant reaction to corticosteroids or lidocaine

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Matthew Pingree, M.D.

Closed for enrollment

More information


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