Arthroscopic Partial Meniscectomy in OA: A 12-Year Follow-Up

Overview

About this study

The goals of this continuation of MeTeOR are to determine: a) whether the greater structural damage observed at five years in subjects treated with APM persists over 12 years; and b) whether structural changes observed in the first five years are associated with worse pain and function and greater TKR utilization at 12 years. We propose the following aims:

  1. Conduct a 12-year follow-up visit of MeTeOR subjects to characterize the extent of cartilage damage over 12 years and identify factors associated with OA progression. MeTeOR participants will complete questionnaires and performance tests and undergo MRI and radiographs 12 years after randomization. Our analyses of cartilage damage will account for clinical and demographic features at baseline and prognostically salient events occurring over follow-up. We hypothesize that subjects with greater baseline levels of cartilage damage and those treated with APM will experience greater cartilage damage over 12 years.
     
  2. Assess whether the extent of structural progression over the first five years post-treatment in persons with OA and meniscal tear predicts worse clinical outcomes at 12 years. We hypothesize that more rapid progression over the initial five years will be predictive of greater pain, worse functional status, worse performance test results, and higher use of TKR at 12 years, independent of clinical and demographic features ascertained over the first five years. We will also assess the extent of progression in cartilage damage that is predictive of a clinically meaningful difference in KOOS Pain scores.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Participants with knee pain of at least four weeks duration and present with at least one mechanical symptom (e.g., clicking, popping, locking, giving way).
  • Potential subjects required to have meniscal tear confirmed by MRI and evidence of cartilage damage or osteophyte on MRI or radiograph.

Exclusion Criteria:

  • Subjects with inflammatory arthritis, prior APM, or workers’ compensation, as well as subjects with Kellgren-Lawrence (KL) Grade 4 radiographs (advanced OA).

 

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Adam Tagliero, M.D.

Closed for enrollment

Contact information:

Ciara Terry M.S.

(507) 538-3562

Terry.Ciara@mayo.edu

More information

Publications

Publications are currently not available