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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 21-30 of 122 for knee

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  1. Confirmatory Study of NeoCart in Knee Cartilage Repair

    Rochester, MN

  2. A Study to Evaluate the Safety and Feasibility of Intra-articular Transplantation of Autologous Adipose Derived Stromal Vascular Fraction (SVF) for Treatment of Osteoarthritis of the Knee

    Jacksonville, FL

  3. A Study of Diagnostic Accuracy of The Mi-eye2™ Compared to Magnetic Resonance Imaging in Knee Arthroscopy Patients

    Scottsdale/Phoenix, AZ

  4. Using Ice Around Postoperative Total Knee Incisions – Does This Make Sense?

  5. A Study of the Safety of Joint Injected Sc-rAAV2.5IL-1Ra (a Virus Carried Gene Therapy) in Patients with Moderate Knee Osteoarthritis

    Rochester, MN

  6. Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression

    Rochester, MN, Jacksonville, FL

  7. A Study to Evaluate Functional Predictive Value of Collective Outcome Measure(s) Status Post Total Hip/Knee Arthroplasty

    Jacksonville, FL

  8. Comparison of Three Surgical Techniques to Achieve Patella Symmetry During Resection

    Rochester, MN

  9. Periarticular Bupivacaine + Meloxicam ER Solution Versus Standard Practice During Total Knee Arthroplasty

    Rochester, MN

  10. A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain

    Jacksonville, FL

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