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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 11-20 of 122 for knee

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  1. A Study to Compare the Effectiveness of Adductor Canal Pain Catheters Following Total Knee Arthroplasty

    Jacksonville, FL

  2. A Study of the Safety and Usability of Culture Expanded STEM Cells Derived from the Patient's Own Fat Tissue for Treatment of Knee Osteoarthritis

    Rochester, MN

  3. A Study of Giving Celecoxib and Dexamethasone with Manipulation Under Anesthesia to Treat Postoperative Stiffness after Total Knee Replacement Surgery

    Rochester, MN

  4. A Study to Compare A-CP HA Kit, Hyaluronic Acid and Placebo To Treatment Knee Osteoarthritis

    Jacksonville, FL

  5. Randomized Controlled Trial of Tranexamic Acid in Total Knee Arthroplasty: Intravenous vs. Topical

    Rochester, MN

  6. Dexamethasone in Total Knee Arthroplasty

    Rochester, MN

  7. Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for TKA

    Rochester, MN

  8. RCT Comparing Robotically-Assisted vs. Manually-Executed Total Knee Arthroplasties

    Rochester, MN, Scottsdale/Phoenix, AZ, Jacksonville, FL

  9. Cooled Radiofrequency vs. Hyaluronic Acid to Manage Knee Pain

    Rochester, MN

  10. A Study of Patient Satisfaction Comparing Medial Constrained Versus Posterior Stabilized Total Knee Arthroplasty from a Single Design

    Rochester, MN

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