Clinical Trials

The purpose of this study is to evaluate the feasibility and effectiveness of adopting the use of a Hypertension management interactive care plan (ICP) using a remote BP monitoring device in primary care practice (device connected BP ICP).

The purpose of this study is to evaluate the effectiveness of a calming virtual reality (VR) environment in reducing office blood pressure (OBP) among patients with suspected white coat hypertension (WCH) or white coat effect (WCE). Effectiveness will be assessed by comparing pre- and post-VR OBP measurements. WCH/WCE diagnosis will be confirmed using ambulatory blood pressure monitoring (ABPM).

Hypertension is the major risk factor for cardiovascular and cerebrovascular diseases worldwide. The escalating prevalence of inadequate sleep now parallels that of hypertension. Observational and experimental evidence favoring a causal relation between insufficient sleep and hypertension are particularly compelling - sleeping 6 hours or less per night is associated with a 20-32% higher probability of incident hypertension. Since sleep curtailment is largely voluntary, sleep deficiency may be corrected and the detrimental health consequences potentially reversed. In this study the investigators aim to investigate the effects of 8 weeks of sleep enhancement/extension vs health education in prehypertensive and stage 1 hypertensive ...

The purpose of this study is to learn about whether a community health clinic program on heart disease risk factors delivered through a digital app on smartphones and tablet devices will promote healthy habits and improve blood pressure among African-Americans.

The purpose of this study is to determine how hypertension impacts blood pressure responses during exercise. 

This is a Phase Ib, open-label, randomized, multicenter, two-arm study designed to assess the safety, efficacy, and pharmacokinetics of cobimetinib administered in combination with niraparib, with or without atezolizumab, to patients with advanced platinum-sensitive ovarian cancer.

The primary goal of this study is to evaluate the overall user experience of the Pregnancy Coach and ensure that it is well tolerated and used properly before moving to a larger randomized efficacy trial.

Hypertension is a major risk factor for cardiovascular and renal disease, and a leading cause of premature mortality worldwide. Early hypertension studies showed that treating elevated blood pressure (BP) reduces patients' risk of cardiovascular disease and all-cause mortality. In subsequent research, patients achieved greater improvement in cardiovascular outcomes when their treatment was aimed at a moderate systolic BP target (<150mmHg) than at higher targets. Although observational data suggest that even lower BP targets may be beneficial, this has not been seen in randomized trials; instead, "intense" treatment of hypertension (i.e., to a target systolic BP <120mmHg) was found to have ...

The purpose of this study is to determine if ultrasound waves (SW) treatment changes single kidney blood flow, restores kidney function, increases the number of circulating endothelial progenitor cell (EPC), or lowers high blood pressure.

The purpose of this study is to evaluate the cardiovascular properties of MANP in African Americans (AA) with hypertension.

The aims of this study are to determine the types and severity of previously undiagnosed sleep deficiencies in otherwise healthy Somali Americans, apply a research framework to define psychosocial, behavioral, environmental, and biological mechanisms mediating sleep deficiencies in Somali Americans, and examine the relationship between sleep deficiencies and increased blood pressure in Somali Americans.

The purpose of this study is to assess if it is possible to use a carotid MRI/MRA to see if cholesterol lowering medication is causing a reduction in the amount of plaque in the arteries.

The mian objective of this small pilot study is to evaluate the efficacy of an individualized breathing protocol on lowering blood pressure among adults with borderline or elevated BP (SBP≥130mmHg, DBP≥90mmHg, or both) as well as their effects on other reported health measures such as sleep, anxiety, and depression. 

The aim of this study is two fold: First the investigators want to determine the safe and most effective dose of subcutaneous (SQ) BNP in subjects with resistant hypertension. Second, the investigators want to demonstrate efficacy of chronically (one week) administered SQ BNP in resistant hypertension in reducing blood pressure.

Evidence suggests that roughly 30% of the US adult population sleeps less than 7 hours per night, and those who do show 20-52% increased risk to develop cardiovascular diseases, particularly hypertension. 

The purpose of this study is to look at the cardiovascular and metabolic effects of prolonged sleep in prehypertensive and stage 1 hypertensive people who report habitual short sleep.

The purpose of this study is to determine if the wrist or forearm is more accurate in blood pressure measurement when the care team is unable to obtain an upper arm measurement in an outpatient clinic setting.

Blood pressure rises in postmenopausal (PM) women and may be caused by widespread microvascular vasodilator dysfunction in conjunction with increased efferent sympathetic vasoconstrictor nerve activity. The goal of this study is to measure the effects of regular physical activity on vasodilator effects of acute administration of estrogen in postmenopausal women.

The primary purpose of this study is to determine the effect of latanoprostene bunod (LBN) ophthalmic solution 0.024% (a single dose and 7 days of once daily [QD] dosing) on 2 aspects of aqueous humor (AqH) dynamics (episcleral venous pressure [EVP] and outflow facility) in participants with ocular hypertension (OHT).

SYMPHONY is prospective, multi-center, open-label, single-arm, Phase 3b psychometric validation study of the PAH-SYMPACT, a new quality of life questionnaire for patients with pulmonary arterial hypertension. Patients will be in the study for 5 1/2 months, 4 months of which they will receive macitentan, 10 mg, once daily.

The primary objectives are to demonstrate the final content validity of the PAH SYMPACT instrument, to demonstrate the psychometric characteristics of reliability and construct validity of the PAH-SYMPACT instrument, and to demonstrate the ability of the PAH SYMPACT instrument to detect change. The secondary objective is to assess the safety of macitentan in ...

The purpose of this study is to determine how menopause influences blood pressure responses during exercise in women.

This study is being done to see how a subcutaneous (SQ or subcu) injection of a new natriuretic peptide, or hormone, called MANP affects your blood pressure, the glucose and lipids levels and other peptide (hormone) levels in your blood.

24-week study to evaluate the efficacy and safety of macitentan for the treatment of portopulmonary hypertension.

The RPD Pilot trial will evaluate the safety and effectiveness of Verve Medical's RPDTM renal denervation system for hypertensive patients with uncontrolled blood pressure, despite use of two anti-hypertensive medications and lifestyle changes. The novelty of the RPDTM system relates to its placement via natural orifice into the pelvis of the kidney (bilaterally) for delivery of radiofrequency energy to ablate the nerves that pass through the outer wall of the renal pelvis, a technique referred to as renal pelvic denervation (RPD).

Evidence suggests a relationship between sleep deprivation and cardiovascular disease. The investigators wish to determine whether 9 nights of modest sleep restriction results in activation of cardiovascular disease mechanisms, thus potentially increasing the risk of cardiovascular disease. The investigators hypothesize that sleep restriction will result in elevated blood pressure, inflammation, and neurocognitive deficits.

The investigators believe epilepsy alters the way the body controls blood pressure, heart rate and breathing, and these changes increase the risk of sudden unexpected death in patients with epilepsy (SUDEP). SUDEP-7 is a risk scoring tool which may correlate with these changes to the heart and blood vessels. This research study measures those differences which may help identify new markers to help predict those patients at greatest risk in the future.

The purpose of this study is to evaluate the safety, tolerability and effect of 1 or 2 mg baxdrostat versus placebo, administered once daily (QD) orally, on the reduction of systolic blood pressure in approximately 720 participants aged ≥ 18 years with hypertension, despite a stable regimen of 2 antihypertensive agents at baseline, one of which is a diuretic (uncontrolled hypertension); or ≥ 3 antihypertensive agents at baseline, one of which is a diuretic (treatment-resistant hypertension).

The purpose of the study is to show the blood pressure lowering effect of aprocitentan, a new drug, when added to other anti-hypertensive drugs of patients with difficult to control (resistant) high blood pressure (hypertension), and to show that blood pressure reduction is kept for long period of time.

The purpose of this research study is to better understand why patients with a disease that causes problems with the autonomic nervous system often have high blood pressure when they lie down. We hope that if we learn more about the cause for this problem, we will be able to treat the problem better in the future.

The objectives of this study are to demonstrate that patients with CNS hypersomnias exhibit cardiovascular and cognitive disturbances, and to demonstrate that CNS medications medications impact these cardiovascular and cognitive disturbances.

The purpose of this study is to learn how uterine fibroids may be connected to heart disease and high blood pressure. It is not known what causes fibroids, but they frequently occur in women who also have high blood pressure, heart disease, and stroke. The investigators of this study want to learn if certain changes in the blood vessels or nerve activity can put women at risk for these diseases and for fibroids.

We propose a pilot study to assess safety and benefit of renal artery ablation at the time of planned atrial fibrillation ablation.

A surveillance of respiratory tract related adverse events in patients treated with Tyvaso® (treprostinil) Inhalation Solution versus other FDA approved therapies.

Hypothesis: We hypothesize that patients from the Family Medicine Department at Mayo Clinic Florida who participate in RPM will have significantly reduced emergency room visits, hospitalizations, and hospital contacts.  

Aims, purpose, or objectives: In this study, we will compare the RPM group to a control group that does not receive RPM. The primary objective is to determine if there are significant group differences in emergency room visits, hospitalizations, outpatient primary care visits, outpatient specialty care visits, and hospital contacts (inbound patient portal messages and phone calls). The secondary objective is to determine if there are ...

The purpose of this study is to determine whether short-term treatment with Fisetin reduces the rate of death and long term complications related to COVID-19.

The purpose of this study is to evaluate the effietiveness of remdesivir (RDV) in reducing the rate of of all-cause medically attended visits (MAVs; medical visits attended in person by the participant and a health care professional) or death in non-hospitalized participants with early stage coronavirus disease 2019 (COVID-19) and to evaluate the safety of RDV administered in an outpatient setting.