Vascular Function and Uterine Fibroids


About this study

The purpose of this study is to learn how uterine fibroids may be connected to heart disease and high blood pressure. It is not known what causes fibroids, but they frequently occur in women who also have high blood pressure, heart disease, and stroke. The investigators of this study want to learn if certain changes in the blood vessels or nerve activity can put women at risk for these diseases and for fibroids.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Women 25-50 years old
  • Premenopausal

Exclusion Criteria:

  • Postmenopausal
  • Pregnant or currently breastfeeding
  • Using blood pressure medications or anti-depression medications
  • High blood pressure
  • Diabetes
  • Disease in the kidneys, lungs, or blood vessels
  • Chronic diseases (for example: Crohn's disease, rheumatoid arthritis, bipolar mood disorder, etc.)
  • Smoker
  • High cholesterol
  • BMI higher than 30

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Michael Joyner, M.D.

Closed for enrollment

More information


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