A Study to Understand Why Laying Down May Influence High Blood Pressure in Patient's with a Disease that Causes Problems with the Autonomic Nervous System


About this study

The purpose of this research study is to better understand why patients with a disease that causes problems with the autonomic nervous system often have high blood pressure when they lie down. We hope that if we learn more about the cause for this problem, we will be able to treat the problem better in the future.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

MSA and PAF:

  • Males or females age 18-75 years.
  • Clinically diagnosed as probable MSA or probable PAF based on established research criteria.
  • Orthostatic BP drop ³30 mmHg systolic and/or ³15 mmHg diastolic within 3 minutes of head-up tilt.
  • Supine BP ³ 160 mmHg systolic and/or 95 mmHg diastolic.

Control Subjects:

  • Males or females age 18-75 years.
  • Normal autonomic reflex screen.

Exclusion Criteria:

  • Pregnant/lactating females – a pregnancy test will be required for women of childbearing potential.
  • The presence of failure of organ systems or systemic illness that can affect autonomic function.
  • Concomitant therapy with anticholinergic, alpha- and beta-adrenergic antagonists or other medication which could interfere with testing of autonomic function.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Wolfgang Singer, M.D.

Closed for enrollment

Contact information:

Tonette Gehrking CAP

(507) 284-0336


More information


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