Sleep Extension and Blood Pressure


About this study

Evidence suggests that roughly 30% of the US adult population sleeps less than 7 hours per night, and those who do show 20-52% increased risk to develop cardiovascular diseases, particularly hypertension. 

The purpose of this study is to look at the cardiovascular and metabolic effects of prolonged sleep in prehypertensive and stage 1 hypertensive people who report habitual short sleep.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age: 18 to 65 years old (inclusive).
  • Gender: both males and females.
  • Body mass index (BMI): 18.5-34.9 kg/m^2.
  • Habitual sleep duration < 7 hours.
  • Presence of either:
    • Prehypertension: office systolic BP (SBP) 120-139 mmHg and/or diastolic BP (DBP) 80-89 mmHg;
    • Stage 1 hypertension: office SBP 140-159 mmHg and/or DBP 90-99 mmHg.
  • Either on no prescription medications (other than oral contraceptive pills, or intrauterine devices) or on stable medical regimen for at least 1 month, if taking prescription medications for chronic conditions.
  • Not pregnant or breast feeding and not intending to become pregnant or breast feed.
  • Not a current smoker or tobacco user.
  • Ability to provide written informed consent.

Exclusion Criteria:

  • Vulnerable study populations will be excluded.
  • Pregnancy.
  • Smoking.
  • Presence of overt cardiovascular diseases, diabetes, chronic kidney disease, cancer, sleep disorders, psychiatric disorders.
  • If taking prescription medications for chronic conditions, change in therapy (type, frequency and/or dosage) over the previous month.
  • Habitual sleep duration ≥ 7 hours.
  • Excessive alcohol (≥ 15 drinks/week in men and ≥ 8 drinks/week in women) and/or excessive caffeine intake (> 400 mg).
  • Currently on a diet and/or actively trying to lose weight.
  • Currently or previously (during the past 2 months) participation in any other research study at the discretion of study personnel.
  • Blood/plasma donation during the past 2 months.
  • Unwillingness or inability to adjust sleep schedule.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Virend Somers, M.D., Ph.D.

Open for enrollment

Contact information:

CPL Hypertension Sleep Study

More information


Publications are currently not available

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