dementia

Displaying 76 studies

  • A Study of the Risk of Risk of Dementia and Heart Failure in Total Joint Arthroplasty Rochester, MN

    This project is focused on understanding the risk of cognitive impairment and dementia in total hip and total knee arthroplasty patients. It involves 4 aims:

    AIM 1. To determine the risk of dementia in patients with TJA. Using the REP, we will identify a population-based cohort of 9,000 TJA patients and a matched cohort of 9,000 non-TJA patients. The overall risk of dementia and subtypes will be compared between the two cohorts.

    AIM 2. To determine cognitive function and neuroimaging measures in patients with TJA. Within the existing data from the MCSA cohort (IRB: 14-004401), we ...

  • Imaging Dementia—Evidence for Amyloid Scanning (IDEAS) Study Rochester, MN; Jacksonville, FL

    The Imaging Dementia—Evidence for Amyloid Scanning (IDEAS) Study will establish an open-label, longitudinal cohort study to assess the impact of amyloid PET on patient outcomes. The study will be performed in accordance with the Center for Medicare & Medicaid Services (CMS) policy of Coverage with Evidence Development (CED) in Medicare beneficiaries who meet the Appropriate Use Criteria (AUC) for amyloid PET (Johnson et al. 2013). Our hypothesis is that amyloid PET will decrease uncertainty and increase confidence in the underlying cause of cognitive impairment, that this will translate into earlier counseling and interventions in these domains, and that these interventions ...

  • Tau PET Imaging in African Americans Jacksonville, FL; Rochester, MN

    The purpose of this study is to gather information and learn more about imaging tests in racially different people who are cognitively normal or have dementia.

  • Decreasing Agitation in Patients with Dementia Through the Use of Weighted Blankets Rochester, MN

    The purpose of this study is to reduce behaviors and psychotic symptoms of dementia by using a weighted blanket as a non-pharmacological method to decrease agitation and distress in the elderly population.

  • Prospective Measures of Outcome in Rapidly Progressive Dementia Jacksonville, FL

    This study will conduct assessment of patients with rapidly progressive dementia (RPD) to review clinical information and perform additional assessments to better understand the disease. Cognitive impairment and function will be assessed concurrent with clinical assessments using validated measures applied in the assessment and monitoring of patients with age-related neurodegenerative diseases. Clinical information will be combined with interval blood/serum, genetic (DNA, analyses of associated measures of transcription factors and proteins, with integration of induced pluripotent stem cell models), cerebrospinal fluid (CSF) and neuroimaging biomarkers when available. The ability of these novel measures to predict outcomes and clinical / pathological diagnoses will be ...

  • Brain Health and Dementia Prevention Registry Jacksonville, FL; Rochester, MN

    The purpose of this study is to create a registry of patients having a clinical diagnosis and collect demographics, cognitive testing, blood and cerebrospinal fluid so that biomarkers and genetic difference can be found in different patient groups.

  • A Study Using Genetic Panel to Assist in Diagnosis of Hereditary Young Onset Dementia Scottsdale/Phoenix, AZ

    The purpose of this study is to use a specific gene panel to assist in the diagnosis of a hereditary form of young onset dementia.

  • Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech Rochester, MN

    The study is designed to determine the relationship between structural and functional changes in the brain on imaging and progression of speech and language, neurological and neuropsychological features in patients with neurodegenerative apraxia of speech (AOS).

  • A Study to Improve the Quality of Dementia Care Rochester, MN

    The purpose of this study is to change the way we care for those with advanced dementia in memory care units. Through integrated technologies and innovative architectural build, the specific aims are to reduce symptom burden, psychotropic medication use, dementia related behaviors, caregiver burden and health care utilization while improving sleep, mood, and function for those who are currently residing in memory care units.

  • Long-Term Extension Study of Intepirdine (RVT-101) in Subjects With Dementia With Lewy Bodies: Jacksonville, FL; Rochester, MN

    This 6-month extension study will provide further information regarding the long-term safety and tolerability of intepirdine (RVT-101) in subjects with Dementia with Lewy bodies (DLB) who have participated in the double-blind, placebo-controlled, lead-in study RVT-101-2001.

  • A Study of Armodafinil for Patients with Dementia with Lewy Bodies Rochester, MN

    The purpose of this study is to examine the effects of the medication Armodafinil in patients who have dementia with Lewy bodies which is associated with memory loss and other thinking problems, excessive daytime sleepiness, hallucinations, delusions, apathy, and reduced quality of life.

  • Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects Jacksonville, FL; Rochester, MN

    This study is being done to learn more about normal thinking and behavior, mild thinking and behavior problems, Frontotemporal Dementia and other forms of dementia in families in which one or more relatives have a mutation associated with Frontotemporal Dementia.

  • Cognitive Change in Behavioral Variant Frontotemporal Dementia (FTD) Rochester, MN

    The objectives of the study are to; (1) estimate the change in disease -related cognitive decline over 1 year on a battery of cognitive tests administered to participants with early-stage symptomatic Behavioral Variant Frontotemporal Dementia (bvFTD) phenotypic variant; (2) identify the cognitive test or brief battery of cognitive tests which are the most sensitive to detect bvFTD progression; (3) determine the optimal schedule of administration of cognitive tests to detect bvFTD progression; (4) evaluate the relationship between cognitive tests and measures of behavior, function, caregiver's burden, quality of life (QOL); and (5) obtain blood samples for genetic and exploratory biomarkers ...

  • ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) Rochester, MN; Jacksonville, FL

    The purpose of this study is to evaluate sporadic (s-) and familial (f-) frontotemporal lobar degeneration (FTLD) patients and asymptomatic family members of f-FTLD patients, characterizing the cohorts longitudinally and informing clinical trial design.  FTLD is a neurodegenerative disorder of the nervous system which there are no approved treatments or cures.

    The study has two arms: a “longitudinal arm” involving a comprehensive assessment of clinical, functional, imaging, and biofluid data collection, and a “biofluid-focused arm” involving limited clinical data to accompany biospecimen collection.

  • Study Evaluating Intepirdine (RVT-101) in Subjects With Dementia With Lewy Bodies: The HEADWAY-DLB Study Jacksonville, FL; Rochester, MN

    This study seeks to evaluate the efficacy and safety of intepirdine (RVT-101) in patients with dementia with Lewy bodies.

  • A Study to Evaluate Safety of Long-term AL001 Dosing in FTD Patients Rochester, MN

    The puppse pf tjos stidu os tp evaluate the safety, tolerability, pharmacokinets (PK) and pharmacodynamics (PD) of AL001 in participants with a Granulin mutation or C9orf72 mutation causative of frontotemporal dementia.

  • Remote Blood Biomarker Monitoring in Frontotemporal Lobar Degeneration Rochester, MN; Jacksonville, FL

    The purpose of this study is to collect and analyze blood specimens from individuals carrying known familial frontotemporal lobar degeneration (f-FTLD) mutations compared to a control group of individuals without known f-FTLD mutations.  

  • A Study of Change in Imaging Biomarkers of Dementia with Lewy Bodies (DLB) and Associations with Cognitive and Functional Decline Jacksonville, FL; Rochester, MN

    To determine the paths of change in imaging biomarkers of DLB and their associations with rate of cognitive and functional decline.

  • Safety and Efficacy Study Evaluating TRx0237 in Subjects With Behavioral Variant Frontotemporal Dementia (bvFTD) Jacksonville, FL; Rochester, MN

    The purpose of this study is to demonstrate the safety and efficacy of TRx0237 in the treatment of patients with behavioral variant frontotemporal dementia (bvFTD).

  • A Study to Evaluate PR006 in Patients with Frontotemporal Dementia with Progranulin Mutations (FTD-GRN) Jacksonville, FL

    The purpose of this study is to evaluate the safety and effect of intra-cisternal PR006 administration on progranulin protein (PGRN) levels in patients with frontotemporal dementia with progranulin mutations (FTD-GRN). Three escalating dose (low dose, medium dose and high dose) cohorts are planned. 

  • Study to Assess the Safety, Tolerability, and Pharmacodynamic (PD) Effects of FRM-0334 in Subjects With Prodromal to Moderate Frontotemporal Dementia With Granulin Mutation Rochester, MN

    The purposes of this study are to investigate the safety, tolerability, and pharmacodynamics of FRM-0334 in subjects with prodromal to moderate frontotemporal dementia with granulin mutation.

  • Open-Label Study of TRx0237 in Subjects With Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia (bvFTD) Jacksonville, FL; Rochester, MN

    The purpose of this study is to provide subjects who have completed participation in a Phase 2 or Phase 3 trial with TRx0237 continued access to therapy and to evaluate the long-term safety of TRx0237.

  • A Study Evaluating Nelotanserin for Treatment of Visual Hallucinations in Subjects with Lewy Body Dementia Rochester, MN

    The purpose of this study is to evaluate the safety and effectiveness of Nelotanserin for the treatment of visual hallucinations in patients with Lewy body dementia.

  • Behavioral Interventions to Prevent or Delay Dementia Scottsdale/Phoenix, AZ; Jacksonville, FL; Rochester, MN

    This study will compare the effectiveness of different combinations of 5 types of behavioral interventions across patient-centered outcomes. It will also evaluate which outcomes (e.g. quality of life, cognition, function, mood) matter most to people at risk for dementia and their care partners. The results of this study have the potential to direct patients, families, and health care providers as to which combinations of behavioral interventions provide the greatest potential impact on which dementia prevention outcomes. Greater use of behavioral strategies that are targeted to the outcomes of most important to the patient will likely improve patient compliance and treatment ...

  • A Study to Collect Blood DNA Samples from Patients with Clinically Diagnosed Alzheimers Disease, Lewy Body Disease, and Frontotemporal Degeneration Rochester, MN

    The purpose of this study is to collect blood samples for DNA analysis from patients clinically diagnosed with Alzheimers disease, Lewy Body disease, and Frontotemporal degeneration.

  • Effects of Aging and Aerobic Exercise Training on Brain Glucose Metabolism Rochester, MN

    Aging is associated with a loss of brain function and conditions such as dementia and Alzheimer's disease. It is likely that decreased brain metabolism is contributing to the progression of age related degenerative diseases. Aerobic exercise training can increase brain volumes and is associated with decreased risk for degenerative brain conditions. However, little is know about the changes that occur to brain metabolism with aerobic training and aging.

  • An Efficacy and Safety Study of JNJ-54861911 in Participants Who Are Asymptomatic at Risk for Developing Alzheimer's Dementia Jacksonville, FL

    The purpose of this study is to evaluate whether treatment with JNJ-54861911 slows cognitive decline compared with placebo treatment, as measured by a composite cognitive measure, the Preclinical Alzheimer Cognitive Composite (PACC), in amyloid-positive participants who are asymptomatic at risk for developing Alzheimer's dementia.

  • A Study to Evaluate Compensatory Training to Support Everyday Function and Adherence to Brain Healthy Lifestyle Changes in Those at Risk for Alzheimer's Disease Scottsdale/Phoenix, AZ

    The primary purpose of this study is to evaluate acceptability of a combination compensation development and lifestyle modification program for brain health in those with subjective cognitive complaint without objective impairment measured by: a) the proportion of invited participants who chose to enroll; and b) quantitative and qualitative program satisfaction ratings.

  • A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies Rochester, MN; Jacksonville, FL

    The primary objective is to evaluate the long-term safety and tolerability of aducanumab after a wash-out period imposed by discontinuation of feeder studies in participants who had previously received aducanumab (i.e., previously treated participants) or who had previously received placebo (i.e, treatment-naïve participants).

  • A Study of the Effectiveness of LY3314814 in Patients with Mild Alzheimer's Disease Dementia Jacksonville, FL

    The purpose of this study is to evaluate the effectiveness of LY3314814 in the treatment of people who have mild Alzheimer's disease dementia.

  • 221AD302 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease Jacksonville, FL

    The primary objective of the study is to evaluate the efficacy of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) score as compared with placebo in participants with early AD. Secondary objectives are to assess the effect of monthly doses of aducanumab as compared with placebo on clinical progression as measured by Mini-Mental State Examination (MMSE), AD Assessment Scale-Cognitive Subscale (13 items) [ADAS-Cog 13], and AD Cooperative Study-Activities of Daily Living Inventory (Mild Cognitive Impairment version) [ADCS-ADL-MCI].

  • Advanced Care Planning in Dementia Jacksonville, FL

    The goal of this study is to gain a better understanding of the status of advanced care planning among caregivers of patients with dementia and examine how this differs by race and disease stage.

  • A Study to Evaluate Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease Rochester, MN

    The purpose of this study is to investigate how abrupt loss of ovarian hormones following bilateral oophorectomy affects overall aging, physical performance, and cognitive function, including the risk for Alzheimer’s disease in women who had this procedure performed prior to natural menopause for benign conditions.

  • An Efficacy and Safety Trial of MK-8931 in Mild to Moderate Alzheimer's Disease (P07738) Scottsdale/Phoenix, AZ

    This study consists of two parts, Part I and Part II. The purpose of Part I of the study is to assess the efficacy and safety of MK-8931 compared with placebo administered for 78 weeks in the treatment of Alzheimer's Disease (AD). The primary study hypotheses for Part I are that at least one MK-8931 dose is superior to placebo at 78 weeks of treatment with respect to change from Baseline in Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog) score and that at least one MK-8931 dose is superior to placebo at 78 weeks of treatment with respect to change ...

  • An Extension Study of ABBV-8E12 in Early Alzheimer's Disease (AD) Jacksonville, FL

    The purpose of this study is to assess the long-term safety and tolerability of ABBV-8E12 in subjects with early Alzheimer's disease (AD).

  • Evaluation of Retinal Imaging in Patients with Alzheimer’s Disease Rochester, MN

    The purpose of this study is to explore the various retinal modalities to determine if they may provide a non-invasive method of identifying populations at risk for developing Alzheimer’s Disease (AD) and predict disease progression.

  • Metabolic Cerebral Imaging in Incipient Dementia (MCI-ID) Scottsdale/Phoenix, AZ

    A brain PET scan is recognized as "reasonable and necessary" for some patients with "a recently established diagnosis of dementia" (Centers for Medicare and Medicaid Services, Decision Memo CAG-00088R, 2004), but evidence is less clear for patients having less severe cognitive problems. A substantial portion of such patients will develop Alzheimer's disease and other forms of dementia, which affect millions of people in the U.S., costing us over $100 billion annually. This project employs a prospective randomized protocol to determine whether PET scanning can help distinguish those patients with early Alzheimer's changes in their brains from those having other causes ...

  • Dementia Questionnaire Jacksonville, FL

    The aim of this study is to develop a dementia questionnaire that is sensitive and specific in detecting the many diseases evaluated in a memory disorder clinic. In this study we have designed an informant-based questionnaire with special emphasis on unique features of different types of dementia.

  • Partnership for Early Detection of Alzheimer's Disease Using Advanced MR Technology Rochester, MN

    The primary objective of this application is to establish the feasibility of widespread clinical use of advanced MRS technology for early AD diagnosis in a strategic alliance between MR physicists at the UMN and physician scientists at Mayo Clinic.

  • A Study to Evaluate the Efficacy and Safety of MABT5102A in Patients with Mild to Moderate Alzheimer's Disease Scottsdale/Phoenix, AZ

    The purpose of this study is to evaluate the safety and effectiveness of MABT5102A in patients who have mild to moderate Alzheimer's Disease.

  • A Study of CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease Jacksonville, FL

    The purpose of this study is to determine the effects of CNP520 on cognition, global clinical status, and underlying AD pathology, as well as the safety of CNP520, in people at risk for the onset of clinical symptoms of AD based on their age, APOE genotype and elevated amyloid.

  • 221AD301 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease Rochester, MN

    The primary objective of the study is to evaluate the efficacy of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) score as compared with placebo in participants with early AD. Secondary objectives are to assess the effect of monthly doses of aducanumab as compared with placebo on clinical progression as measured by Mini-Mental State Examination (MMSE), AD Assessment Scale-Cognitive Subscale (13 items) [ADAS-Cog 13], and AD Cooperative Study-Activities of Daily Living Inventory (Mild Cognitive Impairment version) [ADCS-ADL-MCI].

  • Effectiveness of Florbetapir (18F) PET Imaging in Changing Patient Management and the Relationship Between Scan Status and Cognitive Decline Scottsdale/Phoenix, AZ

    This study is designed to determine the effectiveness of florbetapir (18F) in changing patient management and to evaluate the association between scan status and cognitive decline.

  • TRC-PAD Program: In-Clinic Trial-Ready Cohort Rochester, MN; Jacksonville, FL

    The purpose of this study is to develop a large, well-characterized, biomarker-confirmed, trial-ready cohort to facilitate rapid enrollment into AD prevention trials utilizing the APT Webstudy and subsequent referral to in-clinic evaluation and biomarker confirmation. Participants with known biomarker status may have direct referral to the Trial-Ready Cohort. If you are interested in being selected for the TRC-PAD study, you should first enroll in the APT Webstudy (https://www.aptwebstudy.org/welcome).

  • A Study to Evaluate Intentional Technology Pairing for Caregivers of Patients with Alzheimer’s Disease and Other Types of Dementia Rochester, MN

    The purpose of this study is to facilitate focus groups to assess/identify important qualities and characteristics that dementia caregivers are looking for in a supportive person, and to design a prototype website for matching current and former caregivers.

  • Magnetic Resonance Elastography of Dementia Rochester, MN

    The purpose of this study is to develop and test the effectiveness of an investigational imaging technique called magnetic resonance elastography (MRE) to measure the stiffness (mechanical properties) of tissues.

  • Mayo Alzheimer's Disease Research Center Scottsdale/Phoenix, AZ; Jacksonville, FL; Rochester, MN

    This study is being done to learn more about normal memory and aging, mild memory and thinking problems, Alzheimer's disease and other forms of dementia.

  • Cerebrospinal Fluid (CSF) Biomarkers for Prediction of Dementia Jacksonville, FL; Rochester, MN

    To further investigate biomarkers in CSF as possible predictors for mild cognitive impairment and dementia

  • DNA, Blood and Skin Cell Repository for Research on ALS and Related Neurodegenerative Disorders at Mayo Clinic Florida Jacksonville, FL

    This study is intended to obtain clinical information and establish a repository of DNA, RNA, peripheral blood monocyte, lymphocyte and skin tissue samples from people with ALS and related neurodegenerative motor neuron diseases, people with a family history of these conditions, and healthy people with no family history of these disorders. The samples will be used in future research to learn about how these disorders affect people, what causes these conditions, and how the investigators can tell when someone has this kind of disease. Future research may also include the generation of stem cells from stored blood cell and skin ...

  • DaTSCAN Imaging in Aging and Neurodegenerative Disease Rochester, MN

    The investigators propose using DaTscan in patients with mild cognitive impairment (MCI), Parkinson's disease (PD), dementia with Lewy bodies (DLB), Alzheimer's disease (AD), and other neurodegenerative syndromes and disorders, to test several hypotheses - some confirmatory, and some novel. Such use will provide new data on the potential clinical and research utility of DaTscan in neurodegenerative diseases. The findings on DaTscan will be correlated with clinical diagnoses and other multimodal imaging studies (e.g., MRI, MRS, FDG-PET, and amyloid-PET) to enhance our understanding of neurodegenerative diseases.

  • A Study to Evaluate the Cognitive Effects of Oral p38 Alpha Kinase Inhibitor Neflamapimod in Dementia with Lewy Bodies Rochester, MN

    The purpose of this study is to evaluate the effect of neflamapimod on cognitive function as assessed in a study-specific Cogstate Neuropsychological Test Battery (NTB).

  • Biospecimen Biorepository for the Study of ALS, ALS-FTD and Similar Neurodegenerative Disorders Jacksonville, FL

    The purpose of this study is to collect CSF and blood samples that can be used in future research studies to identify potential biomarkers in blood and CSF collected in ALS patients. Biomarkers are non-genetic elements in your blood and CSF that may help us diagnose and monitor ALS more easily. There are no readily available sources of longitudinal CSF, plasma or serum samples from people with ALS, ALS-FTD or similar neurodegenerative disorders or their family members for use in the identification of potential ALS biomarkers. Future research will examine potential biomarkers in blood and CSF collected over time to ...

  • PiB PET Scanning in Speech and Language Based Dementias Rochester, MN

    The study is designed to determine whether there are clinical features that can be used as biomarkers to predict whether underlying Alzheimer's pathology is the cause of a speech and language based dementia. The primary hypothesis is that the proportion of patients who test positive for beta-amyloid deposition will vary across different speech and language based dementias.

  • Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3) Protocol Jacksonville, FL; Rochester, MN

    Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been realized in informing the design of therapeutic trials in AD. ADNI3 continues the previously funded ADNI-1, ADNI-GO, and ADNI-2 studies that have been combined public/private collaborations between academia and industry to determine the relationships between the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of Alzheimer's disease (AD). The overall goal of the study is to continue to discover, optimize, standardize, and validate clinical trial measures and biomarkers used in AD research.

  • Advancing Reliable Measurement in Alzheimer's Disease and Cognitive Aging Jacksonville, FL

    This study seeks to validate and further develop the NIH Toolbox for Assessment of Neurological and Behavioral Function® (NIHTB) for use in studies of cognitive aging beginning with normal cognition through progression into amnestic Mild Cognitive Impairment (aMCI) and into dementia of the Alzheimer’s Type, early stage (DAT).

  • Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or PDD) Rochester, MN

    This study seeks to evaluate the safety and efficacy of Nelotanserin for the treatment of Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) in subjects with dementia with Lewy bodies (DLB) or Parkinson's disease dementia (PDD).

  • Mayo Clinic Olmsted Study of Aging (MCSA) Rochester, MN

    This study is being done to learn more about normal memory and aging, mild memory and thinking problems, Alzheimer's disease and other forms of dementia. This study will help us determine how often memory problems occur in people in our community, and help to identify factors that may influence changes in memory and thinking skills.

  • Distraction Apron to Reduce Length of Hospital Stay in Patients Requiring Individual Assignment Nursing Cares Rochester, MN

    The purpose of this study is to determine if the use of a distraction apron will decrease the length of hospital stay in patients with dementia or cognitive impairment.

  • Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) Jacksonville, FL; Rochester, MN

    Frontotemporal Lobar Degeneration (FTLD) is the neuropathological term for a collection of rare neurodegenerative diseases that correspond to four main overlapping clinical syndromes: frontotemporal dementia (FTD), primary progressive aphasia (PPA), corticobasal degeneration syndrome (CBS) and progressive supranuclear palsy syndrome (PSPS). The goal of this study is to build a FTLD clinical research consortium to support the development of FTLD therapies for new clinical trials. The consortium, referred to as Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL), will be headquartered at UCSF and will partner with six patient advocacy groups to manage the consortium. Participants will be evaluated at ...

  • A Study to Address End-of-Life Disparities Among African Americans with Mild Cognitive Impairment and Dementia Jacksonville, FL

    The purpose of this study is to reduce disparities in end-of-life care by increasing engagement in advance care planning among African Americans with mild cognitive impairment and early dementia and their caregivers.

  • A Study to Evaluate the Efficacy and Safety of ABBV-8E12 in Subjects With Early Alzheimer's Disease Jacksonville, FL

    This study seeks to evaluate the efficacy and safety of ABBV-8E12 in subjects with Early Alzheimer's Disease.

  • Anti-Bullous Pemphigoid Antibodies in Patients with Neurological Disease Rochester, MN

    The purpose of this study is to learn more about Lewy Body disease and a skin condition called Bullous Pemphigoid.

  • A Study to Develop a Program for those Living Alone with Mild Cognitive Impairment Scottsdale/Phoenix, AZ

    The purpose of this study is to develop a program for individuals living alone with mild cognitive impairment (MCI).

  • Study to Evaluate the Pathophysiology of Multiple System Atrophy, Parkinson's Disease, Parkinson's Disease with Autonomic Failure and Dementia with Lewy Bodies Using Microneurographic Recordings of Muscle Sympathetic Nerve Activity Rochester, MN

    The purpose of this study is to understand why patients with multiple system atrophy, Parkinson’s disease, Parkinson’s disease with autonomic failure, and dementia with Lewy bodies have a fall in blood pressure on standing up. It is believed that different patients develop these symptoms for different reasons. The reasons could be:

    • damage to nerve supply to the legs

    • the autonomic nerves are not working properly

    • the brain is not controlling blood pressure or heart rate properly

    This study will look at these different reasons.

  • Biospecimen Collection to Investigate the Causes of ALS Jacksonville, FL

    The purpose of this study is to collect and study blood samples that can be used in current and future research studies to identify genetic risk factors in ALS and identify potential biomarkers in blood collected in ALS patients. Biomarkers are non-genetic elements in your blood that may help us diagnose and monitor ALS more easily. There are no readily available sources of longitudinal DNA, RNA, monocytes, serum or plasma from people with ALS, ALS-FTD or similar neurodegenerative disorders or their family members for use in the identification of potential changes in gene structure over time or biomarkers in ALS. ...

  • Efficacy and Safety Trial of Verubecestat (MK-8931) in Participants With Prodromal Alzheimer's Disease (MK-8931-019) Scottsdale/Phoenix, AZ

    This study consists of two parts, Part I and Part II. The purpose of Part I of the study is to assess the efficacy and safety of verubecestat (MK-8931) compared with placebo administered for 104 weeks in the treatment of amnestic mild cognitive impairment (aMCI) due to Alzheimer's Disease (AD), also known as prodromal AD. Participants will be randomized to receive placebo, or 12 mg or 40 mg verubecestat, once daily. The primary study hypothesis for Part I is that at least one verubecestat dose is superior to placebo with respect to the change from baseline in the Clinical Dementia ...

  • A Biospecimen Repository for Neurodegenerative Disease Research in Cooperation with the National Cell Repository for Alzheimer Disease Jacksonville, FL

    The purpose of this study is to collect clinical data, serial blood samples for plasma, serum, DNA and RNA extraction, and a single time blood sample for peripheral blood monocytes for the preparation of stem cell lines and lymphocytes for the preparation of lymphoblastoid cell lines. There will also be a single time skin biopsy sample for tissue examination and preparation of skin fibroblasts from patients who have familial or sporadic ALS, ALS-FTD or similar neurodegenerative motor neuron disorders, and are participating in NINDS funded research projects in the Mayo Clinic ALS Center.

  • Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder Rochester, MN

    This study seeks to evaluate the long-term safety and effectiveness of nelotanserin for the treatment of visual hallucinations (VHs) and Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) in subjects with Lewy body dementia (LBD).

  • A Study to Evaluate MR of CSF Dynamics Rochester, MN

    The purpose of this study is to evaluate changes in CSF dynamics (e.g., velocity, flow rate) between patients with normal pressure hydrocephalus and healthy controls, as well as patients with other dementia disorders.

  • A Study of the Brain & Body Donation Program Scottsdale/Phoenix, AZ

    The purpose of this study is to study the structure and biochemistry of the brain and/or bodily fluid and tissue after death.  Comparison of specimens from normal and diseased individuals provide essential clues that lead to a greater understanding of the diseased state which, in turn, will lead to new ideas for therapy.

  • A Study to Evaluate Presbycusis and Presbyvestibulopathy and Risk for Mild Cognitive Impairment and Dementia Jacksonville, FL

    The purpose of this study is to examine baseline vestibular and balance problems with cognitive function and diagnosis as compareed to previously studied associations of Presbycusis with cognition function.

  • A Biorepository for the Center for Multiple Sclerosis and Autoimmune Neurology Scottsdale/Phoenix, AZ; Rochester, MN

    The purpose of this study is to establish a repository consisting of clinical information, radiological data, serum, peripheral blood lymphocytes, plasma, cerebrospinal fluid (CSF), urine, stool, DNA and tissue specimens collected from patients who have central nervous system (CNS)  inflammatory diseases. 

  • A Study Evaluating the Use of 48-hour Ambulatory EEG Monitoring in Early Onset Alzheimer’s Disease Jacksonville, FL

    The purpose of this study is to characterize and study the relationship of the clinical risk factors and predictors of seizures and epilepsy in patients with Early Onset Alzheimer's Disease (EOAD) using a 48-hour CAA-EEG.

  • A Study of Early-onset Alzheimer's Disease Jacksonville, FL; Rochester, MN

    The purpose of this Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is designed to look at disease progression in individuals with early onset cognitive impairment . Clinical/cognitive, imaging, biomarker, and genetic characteristics will be assessed across three cohorts: (1) early onset Alzheimer's Disease (EOAD) participants, (2) early onset non-Alzheimer's Disease (EO-nonAD) participants,and (3) cognitively normal (CN) control participants.

  • Cross-sectional, Multinational, Noninterventional Study to Evaluate the Psychometric Comparability of Culturally Adapted Versions of the Global Preclinical Alzheimer’s Cognitive Composite (G-PACC) Jacksonville, FL

    The main goal of this study is to evaluate whether a certain set of memory and thinking tests that are in English also work in other languages after they are translated. The measures will test your memory, thinking, problem solving, and everyday function abilities.

  • A Study to Assess Educational Needs and Perceived Barriers to Care Among Individuals with Chronic Health Conditions and Their Caregivers Jacksonville, FL; Rochester, MN

    The purpose of this study is to assess educational needs and barriers to care in both patients with cancer and other serious chronic conditions, as well as their caregivers.

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