Targeting Neuroinflammation As A Contributing Pathology In Alzheimer’s Disease Dementia

Overview

About this study

The purposes of this study are to determine if neuroinflammation, as measured by PET imaging, is associated with Ab plaques in cognitively impaired vs. cognitively unimpaired participants, to determine if neuroinflammation, as measured by neuroinflammation PET imaging, is associated with the rate of cognitive in the 5 years preceding PET imaging, and to determine if neuroinflammation, as measured by PET imaging, is associated with plasma biomarkers of inflammation or other neurologic diseases and related blood tests.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

1. Males or females 60 years of age or older.

2. Meet the requirements for one of the four groups (CU A−, CU A+, MCI A+, AD A+)

3. Undergoing neurologic evaluation procedures with cognitive testing in the MCSA or ADRC for a minimum of about 3 years.

4. All participants must have had an amyloid PiB PET scan and MRI brain scan within the previous 3 years

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Val Lowe, M.D.	Closed-enrolling by invitation What is this? (?) "Close" Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.	Contact information: Brevin Ndovu 5075387897 ndovu.brevin@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Val Lowe, M.D.

Closed-enrolling by invitation

Contact information:

Brevin Ndovu

5075387897

ndovu.brevin@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials