A Study of the Risk of Risk of Dementia and Heart Failure in Total Joint Arthroplasty


About this study

This project is focused on understanding the risk of cognitive impairment and dementia in total hip and total knee arthroplasty patients. It involves 4 aims:

AIM 1. To determine the risk of dementia in patients with TJA. Using the REP, we will identify a population-based cohort of 9,000 TJA patients and a matched cohort of 9,000 non-TJA patients. The overall risk of dementia and subtypes will be compared between the two cohorts.

AIM 2. To determine cognitive function and neuroimaging measures in patients with TJA. Within the existing data from the MCSA cohort (IRB: 14-004401), we will identify the sub-cohort of 1,200 patients with TJA and compare their cross-sectional and longitudinal cognition and neuroimaging measures with a matched cohort of non-TJA subjects.

AIM 3. To determine the association between serum and synovial fluid metal ion levels with cognitive function and neuroimaging findings. We will prospectively recruit 100 TJA patients presenting for revision TJA and with at least 10 years of exposure to TJA implants. Serum metal ion levels will be measured and TJA patients will undergo cognitive assessments and neuroimaging, similar to the MCSA cohort.

AIM 4. To determine neuropathological features and metal ion levels in postmortem brain autopsy tissue of patients with TJA. We will use stored brain autopsy tissues of 100 patients with TJA and 100 non-TJA subjects.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients with TJA and matched controls.

Exclusion Criteria: 

  • None.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Hilal Maradit Kremers, M.D.

Closed-enrolling by invitation

What is this? (?)
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Christina Stenzel

(507) 538-8112


More information


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