A Study of Change in Imaging Biomarkers of Dementia with Lewy Bodies (DLB) and Associations with Cognitive and Functional Decline

Overview

About this study

To determine the paths of change in imaging biomarkers of DLB and their associations with rate of cognitive and functional decline.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Please contact the study team to discuss whether or not you are eligible to participate in a study.

Inclusion Criteria:

  • Diagnosis of probable DLB, clinical diagnosis of probable DLB will be made using the published criteria, or clinical diagnosis of mild cognitive impairment (MCI) due to Lewy Body disease.
  • At least 18 years of age.
  • Have a reliable informant who personally speaks with or sees that subject at least weekly.
  • Subject is sufficiently fluent in English to complete all measures.
  • Subject must be willing and able to consent to the protocol and undergo up to 6 visits. Baseline visit, 6 month visit and then yearly evaluations (year 1, 2, 3, and 4 from the baseline visit).
  • Subject must be willing and able to undergo neuropsychological testing.
  • Subject must have no contraindication to MRI imaging.

Exclusion Criteria:

  • Presence of another neurologic disorder which could impact findings, such as multiple sclerosis, brain tumors, etc.
  • Subject is unwilling to return for follow-up yearly, undergo neuropsychological testing and MR imaging.
  • If undergoing Tau imaging cannot have QT Prolongation.
  • Subject has no reliable informant.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Neill Graff Radford, M.D.

Open for enrollment

Contact information:

Memory Disorder Clinic - FL

(904)953-6523

Rochester, Minn.

Mayo Clinic principal investigator

Bradley Boeve, M.D.

Open for enrollment

Contact information:

Alzheimer’s Disease Research Center

(507) 284-1324

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20424750

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