Wisconsin Registry For Alzheimer’s Prevention (WRAP)

Overview

About this study

The purpose of this study is to derive person-level estimates of the preclinical window, defined as the interval between the onset of AD proteinopathy and the onset of cognitive decline.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Aged 40-89
Ability to speak English fluently.
Understanding and willingness to undergo study procedures.
Visual and auditory acuity adequate for neuropsychological testing.
A person who knows the participant well and can answer informant-based questionnaires and interviews.

Exclusion Criteria:

Major neurological disorders: A current diagnosis of dementia; certain other major and active diseases involving the brain such as Huntington’s disease.
Current major, severe, and/or unstable schizophrenia, bipolar, or other psychiatric disorder with psychotic features.
Lacks capacity to provide informed consent.

Exclusion Criteria for Roll-over and Follow-up Visits:

Medical condition that makes cognitive testing not feasible or invalid as determined by the study team.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 08/11/2026. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
La Crosse, Wis. Mayo Clinic principal investigator Daniel Anderson, D.O.	Closed for enrollment	Contact information: Jodi Kaseno 6083927187 kaseno.jodi@mayo.edu

Mayo Clinic Location

Status

Contact

La Crosse, Wis.

Mayo Clinic principal investigator

Daniel Anderson, D.O.

Closed for enrollment

Contact information:

Jodi Kaseno

6083927187

kaseno.jodi@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials