cardiovascular disease prevention

Displaying 20 studies

  • Characterizing HIV-related Diastolic Dysfunction Rochester, MN

    The purpose of this study is to better understand how the heart’s health and function is affected by HIV infection and use of active antiretroviral therapy.

  • Cardiovascular Health Promotion Among African-Americans by FAITH! Rochester, MN

    Given the importance of healthy lifestyle practices to cardiovascular disease (CVD) prevention and the utility of church-based interventions in African-American adults, the investigators developed a theory-informed, strategically-planned, health and wellness intervention with Rochester, Minnesota (MN) and Twin Cities area (Minneapolis, St. Paul, MN) churches with predominately African-American congregations. The objective of the study was to partner with churches to implement a multi-component, health education program through the use of core educational sessions delivered through a digital-application accessible on demand via interactive access on computer tablets and the Internet. The overarching goal was to increase the awareness and critical importance of ...

  • A Study to Improve Cardiovascular Health Among African Americans within Faith Communities Rochester, MN

    The purpose of this study is to apply a community-based participatory research (CBPR) approach to rigorously refine and test the feasibility and preliminary effectiveness of our existing cardiovascular (CV) health and wellness digital application (app) prototype to improve CV health according to the American Heart Association Life’s Simple 7 (LS7) framework among African-American (AA) adults within faith communities.

  • A Study to Understand the Extent of Routine Cardiovascular Screening in Patients with Rheumatoid Arthritis Rochester, MN

    The purpose of this study is to understand the extent of routine cardiovascular screening in patients with rheumatoid arthritis to improve management of their cardiovascular disease and optimize cardiovascular preventive strategies for this group of patients.

  • Using Quantitative Measures to Determine the Effectiveness of Standard of Care Preventative Treatments for Cardiovascular Disease in the Homeless Jacksonville, FL

    The purpose of this study is to determine the effectiveness of intensive, guideline-directed, preventative therapies on cardiovascular disease in the homeless population to help develop an appropriate care model for preventing and treating CVD in the homeless.

     


     

  • Evaluating Childhood Cardiovascular Health Outcomes in NEPTUNE and CureGN Rochester, MN

    The purpose of this research study is to learn more about the risks to heart health in children and young adults with nephrotic syndrome. Nephrotic syndrome is a rare kidney condition that can affect children. They may be more likely to develop heart disease, high blood pressure and high cholesterol. We hope that the results of this study will help us to learn which tests should be used to determine which patients are most at risk for developing these illnesses.

  • An Outcomes Study to Assess Statin Residual Risk Reduction with Epanova in High Cardiovascular Risk Patients with Hypertriglyceridemia La Crosse, WI

    The purpose of this study is to evaluate the effectiveness of adding epanova to statin therapy for lowering major adverse cardiovascular events in high cardiovascular risk patients with hypertriglyceridemia.

  • Understanding Return to Play for Athletes with Cardiovascular Disease Rochester, MN

    The purpose of this study is to understand the logistical aspects and the barriers that athletes with cardiovascular disease have faced in the process of returning to play, to understand the decision-making process that occurs among athletes, their families, medical professionals, and the school/club administration in choosing to return to the field, and to understand the contingency/emergency plans in the athletes who returned to play.

  • Reducing CVD Risk in African Americans Faith Communities Rochester, MN

    The ultimate goal of our partnership with local African-American churches is to implement an effective, multi-component intervention to increase awareness of the critical importance of healthy lifestyle in the prevention of cardiovascular disease (CVD). We will utilize the American Heart Association (AHA) prevention strategy, "Life's Simple 7" to address the major risk factors for CVD: diet, smoking, physical inactivity, hypertension, diabetes, cholesterol and obesity in order to improve overall cardiovascular health. Our main strategy consists of a community-based participatory research approach that involves focus groups to assess participant knowledge and beliefs about CVD risk factors prior to program initiation. We ...

  • Atrial Fibrillation Screening and Education Study Rochester, MN

    The purpose of this study is to evaluate the outcomes of a community placed atrial fibrillation (AF) screening and education program

  • A Study to Compare the Effectiveness of an Invasive Treatment Approach versus Conservative Medication Alone Strategy for Patients with Stable Ischemic Heart Disease Jacksonville, FL

    The purpose of this study is to determine if an initial invasive strategy of cardiac catheterization and optimal revascularization with optimal medical therapy is the best management strategy compared with an initial conservative strategy of optimal medical therapy alone for higher-risk patients with stable ischemic heart disease.

  • A Study Validating the "Foods for Health" Portfolio of Functional Food Products, for People Unable to take Statin Drugs Rochester, MN

    The purpose of this study is to evaluate the ability of a range of new, easy to use, proprietary food based products to affect cardiovascular disease (CVD) risk factors by positively impacting blood cholesterol levels in statin intolerant and/or statin unwilling participants.

  • Get Going: Accelerometer-Based Intervention to Promote Physical Activity in Frail Older Adults La Crosse, WI; Rochester, MN

    A multicenter prospective randomized clinical trial testing the hypothesis that a patient-centered actigraphy intervention will result in increased physical activity for frail older adults increase during the critical first 30 days after a cardiovascular hospitalization.

  • A Study to Determine the Impact of Individualized Estrogen Therapy on Cardiovascular Disease Risk Parameters in Young Women after Bilateral Oophorectomy Rochester, MN

    The purpose of this study is to compare the cardiovascular function in young women (<46 years)="" following="" bilateral="" oophorectomy="" who="" are="" treated="" with="" either="" the="" standard="" dose="" of="" estradiol="" (100="" mcg="" transdermal="" patch="" or="" equivalent="" oral="" dose)="" or="" titrated="" estradiol="" dosing="" to="" achieve="" average="" premenopausal="" estradiol="" level="" (80-120="" pg/ml),="" to="" characterize="" the="" relationship="" between="" the="" serum="" estradiol="" level="" and="" cardiovascular="" function="" in="" young="" women=""><46 years) on estradiol replacement after bilateral oophorectomy, and to compare the body composition in young women following bilateral oophorectomy who are treated with either the standard dose of estradiol (100 mcg transdermal patch or equivalent ... years)="" on="" estradiol="" replacement="" after="" bilateral="" oophorectomy,="" and="" to="" compare="" the="" body="" composition="" in="" young="" women="" following="" bilateral="" oophorectomy="" who="" are="" treated="" with="" either="" the="" standard="" dose="" of="" estradiol="" (100="" mcg="" transdermal="" patch="" or="" equivalent="" ...="">

  • A Study to Compare the Effectiveness of Invasive versus Conservative Medical Approaches in Patients with Stable Ischemic Heart Disease and Advanced Chronic Kidney Disease Scottsdale/Phoenix, AZ

    The purpose of the ISCHEMIA-CKD trial is to determine the best management strategy for patients with stable ischemic heart disease (SIHD), at least moderate ischemia and advanced chronic kidney disease (CKD; estimated glomerular filtration rate [eGFR] <30 or on dialysis). This is a multicenter randomized controlled trial with a target randomization of ~1000 patients with advanced CKD and at least moderate ischemia on stress testing. Participants will be assigned at random to a routine invasive strategy (INV) with cardiac catheterization (cath) followed by revascularization plus optimal medical therapy (OMT) or to a conservative strategy (CON) of OMT, with cath and ...

  • A Study of Stress Management Intervention in a Women's Heart Clinic, The Heart SMART Program Rochester, MN

    The purpose of this study is to see how usefull will the Heart SMART program be in moderate or high stress patients who are referred to the Women's Heart and Preventive Cardiology clinics at Mayo Clinic.

  • Treating Breast Cancer Patients Undergoing Trastuzumab Treatment with Carvedilol to Reduce Incidence of Heart Failure Scottsdale/Phoenix, AZ; Jacksonville, FL; Rochester, MN

    The purpose of this study is to evaluate different strategies of cardiovascular therapy with Carvedilol, aiming to reduce the incidence of left ventricular ejection fraction (LVEF) decline and heart failure (HF) in patients undergoing curative intent Trastuzumab for breast cancer.

     

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  • Cardiopulmonary Exercise Testing as a Tool for Cardiac Screening Pre-Transplant Scottsdale/Phoenix, AZ

    The purpose of this study is to determine the change in exercise capacity by comparing VO2 max results pre & post renal transplant.

       

  • A Study to Evaluate Brain Natriuretic Peptides for the Avoidance of Treatment-Related Heart Failure in Breast Cancer Survivors Rochester, MN

    The purpose of this study is to determine if Brain Natriuretic Peptide (NT-pro-BNP) values increase over time in breast cancer survivors and correlate with cardiac dysfunction. This study will define the average NT-pro-B-natriuretic peptide values in female breast cancer patients 1, 2, 3, 4, and 5 years out from anthracycline-based chemotherapy.

  • A Study to Evaluate Cardiopulmonary Exercise Testing in Liver Transplant Candidates Scottsdale/Phoenix, AZ

    The purpose of this study is to determine agreement between cardiopulmonary exercise testing and cardiac stress testing (SOC) for the identification of subclinical coronary artery disease in liver transplant candidates, to determine agreement between cardiopulmonary exercise testing and dobutamine stress echocardiogram (SOC) for the identification of cirrhotic cardiomyopathy in liver transplant candidates, and to determine agreement between peak oxygen consumption from cardiopulmonary exercise testing and the liver frailty index or the six-minute walk test (SOC), for the identification of frailty in liver transplant candidates.

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