A Study to Evaluate Cardiopulmonary Exercise Testing in Liver Transplant Candidates


About this study

The purpose of this study is to determine agreement between cardiopulmonary exercise testing and cardiac stress testing (SOC) for the identification of subclinical coronary artery disease in liver transplant candidates, to determine agreement between cardiopulmonary exercise testing and dobutamine stress echocardiogram (SOC) for the identification of cirrhotic cardiomyopathy in liver transplant candidates, and to determine agreement between peak oxygen consumption from cardiopulmonary exercise testing and the liver frailty index or the six-minute walk test (SOC), for the identification of frailty in liver transplant candidates.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients 50 - 70 years old.
  • Waitlisted patients with cirrhosis or those undergoing LT evaluation at the Mayo Clinic, Arizona Liver Transplant Center. 

Exclusion Criteria:

  • Patients under 50 and over 70 years old.
  • Patients with platelets < 30,000, INR > 3, GFR < 30, left main coronary stenosis, moderate/severe stenotic valvular disease, atrial fibrillation and other arrhythmias, resting ventricular ejection fraction < 50%, portopulmonary hypertension, severe COPD, or an exercise contraindication.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Elizabeth Carey, M.D.

Open for enrollment

Contact information:

Blanca Lizaola-Mayo M.D.



More information


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