Using Quantitative Measures to Determine the Effectiveness of Standard of Care Preventative Treatments for Cardiovascular Disease in the Homeless


About this study

The purpose of this study is to determine the effectiveness of intensive, guideline-directed, preventative therapies on cardiovascular disease in the homeless population to help develop an appropriate care model for preventing and treating CVD in the homeless.



Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • ≥ 18 years of age;
  • Must meet definition of homeless as defined in the Health Act of 2009.
  • Have 1 or more of the following:
    • Documented CVD;
    • A CVD 10-year risk at least 7.5% using the American College of Cardiology ASCVD Risk Estimator Plus;
    • 2 or more CVD risk factors;
    • CVD risk factors include advanced age, smoking history, family history of premature CVD in a first degree relative, hypertension, hyperlipidemia, diabetes.

Exclusion Criteria:

  • Severe psychiatric illness defined by a licensed psychiatrist.
  • Severe liver or muscle disease that precludes use of statins.
  • Documented cirrhosis, or Hep B or Hep C infections, will serve as contraindication.
  • Heavy alcohol abuse defined as drinking 5 or more drinks on the same occasion on each of 5 or more days in the past 30 days (SAMHSA 2015).


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Jacksonville, Fla.

Mayo Clinic principal investigator

Brian Shapiro, M.D., M.A.

Closed for enrollment

More information


Publications are currently not available

Mayo Clinic Footer