Evaluating Childhood Cardiovascular Health Outcomes in NEPTUNE and CureGN


About this study

The purpose of this research study is to learn more about the risks to heart health in children and young adults with nephrotic syndrome. Nephrotic syndrome is a rare kidney condition that can affect children. They may be more likely to develop heart disease, high blood pressure and high cholesterol. We hope that the results of this study will help us to learn which tests should be used to determine which patients are most at risk for developing these illnesses.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  1. Participants age 6-21 years enrolled in either NEPTUNE or CureGN(The lower age limit was chosen based on ability to cooperate with study-related procedures.)

  2. Participants with a diagnosis of FSGS

  3. Participants with a diagnosis of MCNS with active disease defined as follows:

            a) steroid dependent- relapse during corticosteroid therapy or within 2 weeks of discontinuing corticosteroids

            b) frequently relapsing- ≥2 relapses in 6 months or ≥4 relapses in 12 months or

            c) steroid resistant - failure to induce remission with corticosteroids within 8 weeks

     4.   Informed consent from the parent or guardian and assent from a minor of ≥ 7 years

   Exclusion Criteria

  1. Participants with a diagnosis of IgA nephropathy, membranous nephropathy or other glomerular disease that is not FSGS or MCNS

  2. Participants on dialysis or who have a kidney transplant

  3. Participants with major co-morbid conditions such as cardiac disease, pulmonary disease, neurologic disease, diabetes mellitus or a genetic syndrome

  4. Participants/guardians or participants who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Cheryl Tran, M.D.

Closed for enrollment

Contact information:

Julia Byrne



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