Biostatistics Online Modules

The Mayo Clinic Center for Clinical and Translational Science (CCaTS) offers a broad range of statistics-related online modules. To access these modules, you must be logged into the Mayo Clinic network.

Mayo Clinic employees: Enroll now

  1. Access My Learning through HR Connect.
  2. Click "Learning" and search by course title or course code.

Modules

BlueSky Statistics Modules (502E00BLSK0001)

BlueSky is a statistical analysis tool, available via the Mayo Dock, to which Mayo Clinic currently holds an enterprise-wide license. For those who need personalized assistance, the CCaTS Service Center offers one-on-one statistical and epidemiologic consultations.

Modules in this training contain information on:

  • Dataset Creation
  • Creating Variables with Formulas
  • Dataset Manipulation
  • Descriptive Statistics and Saving Output

Working with the Statistician (502E00CMS090018)

Most researchers rely on statisticians to help them analyze their results. What information should you take to your statistical consultation? You and your statistician will both be glad you learned the answer in this module.

Presenter: Felicity T. Enders, Ph.D.

Data-Monitoring Committees (502E00CMS110027)

The Mayo Clinic Institutional Review Board recently issued a guidance document on Data and Safety Monitoring Plan (DSMP) guidelines (Guidance IRB 10379.002). Elements of a DSMP include study-stopping and participant-stopping rules.

All randomized clinical trials must begin with the assumption of clinical equipoise — that either treatment represents a viable alternative. As a study accrues participants, researchers garner information regarding the clinical equipoise assumption and must reach decisions regarding the continuation of the study.

This module addresses many of the logistical aspects associated with interim monitoring of clinical studies, with emphasis on efficacy evaluation, while providing guidance on appropriate statistical considerations for the repeated evaluation of the study data.

Presenter: Rickey E. Carter, Ph.D.

Research Protocols — Guides to Success

Scientific advances are based on reproducible science. At the heart of reproducible science is the research protocol. This module discusses guidelines for protocol preparation consistent with regulatory requirements and best practices. Participants also learn to differentiate a research protocol from a grant application.

The module makes recommendations on the importance for specific and measurable outcome measures in the context of mandatory reporting requirements (for example, Clinicaltrials.gov results reporting). Additionally, it highlights institutional resources that can assist investigators with protocol preparation.

Presenter: Rickey E. Carter, Ph.D.

Beyond Bar and Line Graphs: Time for a New Data Presentation Paradigm

Non-Mayo participants: Enroll here

Data presentation is an essential skill for scientists. Figures are critically important because they often show the data supporting key findings. However, a visually appealing figure is of little value if it is not appropriate for the type of data being presented. This module teaches participants how to select the right type of figures when presenting continuous data in small sample size studies.

The module's systematic review of research articles published in top physiology journals shows that most papers presented continuous data in bar and line graphs. This is a problem, as many different data distributions can lead to the same bar or line graph. The full data may suggest different conclusions from the summary statistics. Papers rarely include scatter plots, box plots and histograms that allow readers to critically evaluate continuous data.

The module directs learners to several resources that allow them to quickly make univariate scatter plots for small sample size studies, including Excel templates and instructions for GraphPad Prism. It also provides links to blog posts from other investigators that show how to make univariate scatter plots and box plots in R. Finally, the module discusses steps that students and investigators can take to improve the quality of data presentation in published papers.

Presenter: Tracey L. Weissgerber, Ph.D.