Essentials of Clinical and Translational Science (ECaTS)

Are you ready to take a deeper dive into the world of clinical and translational science?

Essentials of Clinical and Translational Science (ECaTS) provides medical professionals with foundational knowledge of research terminology, research methods and processes, clinical epidemiology, and biomedical statistics.

Upon completion, learners understand basic terminology and methodological concepts in epidemiology from a clinical perspective. They also learn basic statistical methods used in various clinical study designs. The program prepares learners to review medical literature critically, such as scholarly publications.

Program highlights

  • Thirty hours of educational content available anytime and anywhere.
  • Access to four hours of Fundamentals of Clinical and Translational Science (FunCaTS) at no additional charge.
  • Self-directed and self-paced (asynchronous).
  • Participants will have access to the course materials for one year.
  • A digital badge is awarded upon successful completion of the program.
  • Aligns with IV.A.5.b and IV.A.5.c Accreditation Council for Graduate Medical Education (ACGME) practice-based learning and improvement competency (ACGME Common Program Requirements).
  • Includes content assessed on the United States Medical Licensing Examination (USMLE) Step 1 exam under the competency of Practice-Based Learning and Improvement, which requires understanding and application of the principles of biostatistics and epidemiology (USMLE Step 1 Content Outline and Specifications).


The course cost is $2,500 for non-Mayo participants. Mayo Clinical employee internal pricing is discounted and shown after logging in to the Executive Education registration page.


ECaTS is available to all Mayo Clinic employees and the general public.


Registration is available anytime on our Executive Education registration page.

Disclaimer: The content and program do not fulfill prerequisite requirements for Mayo Clinic Graduate School of Biomedical Sciences graduate credit courses or transfer to the CCaTS Certificate Program or Postdoctoral Master's Degree Program.


The ECaTS online self-paced course can be completed in about 30 hours. It is delivered through two main units, Principles of Epidemiology, delivered by Walter A. Rocca, M.D., M.P.H., and Statistics in Clinical and Translational Science, delivered by Felicity T. Enders, Ph.D. The units are outlined below.

Course outline

  • Principles of Clinical Epidemiology.
    • Introduction and Foundations.
    • The Population Survey: Incidence and Prevalence.
    • The Population Survey: Time, Place and Person.
    • Bias and Causal Inference.
    • Confounding, Mediation, & Interaction: Beyond X & Y.
    • The Case-Control Study.
    • The Cohort Study.
    • The Clinical Trial.
  • Statistics in Clinical and Translational Science.
    • Summary Statistics and Graphing.
    • Confidence Intervals.
    • Confidence Intervals for Binary.
    • Introduction to a Hypothesis.
    • Hypotheses Testing for Continuous Outcomes.
    • Hypotheses Testing for Categorical Outcomes.
    • Graphs for Diagnostic Testing and Survival Data.

The course includes two summative exams, one for each unit, which the learner must pass with a score of 80% or higher to obtain the ECaTS digital badge.

Supplemental curriculum

Included with your registration for ECaTS is our introductory course, Fundamentals of Clinical and Translational Science (FunCaTS). An important introduction to ECaTS, FunCaTS is highly recommended.

Looking for additional online professional development modules? Visit the CCaTS Workforce Development webpage.


Please contact the CCaTS Executive Education and Workforce team with any questions.