Office of Clinical Trials
The Office of Clinical Trials supports clinical trials by advancing efficient trial activation, improving participant access and strengthening innovative trial design.
The office works across Mayo Clinic's campuses to connect research teams, clinical practice leaders, sponsors and centralized research resources. Through shared governance, technology-enabled solutions and coordinated operational support, the Office of Clinical Trials helps reduce administrative burden and address common challenges in clinical research.
What we support
The Office of Clinical Trials supports clinical trials through three connected areas of focus: efficient trial activation and conduct, improved access to trial participation, and translation of novel and pragmatic clinical trial designs into practice.
Vision
Mayo Clinic has a strong history in clinical research. The Office of Clinical Trials aims to be a trusted partner in planning, running and translating clinical trials for patients, researchers, industry and government agencies.
Mission
The office's mission is to help improve patient health by providing researchers and study teams with high-level support for the design, activation, conduct and translation of clinical trials.
Efficient trial activation and conduct
The team supports rigorous protection for human research participants while helping study teams activate and conduct trials more efficiently. This includes streamlined activation processes, centralized resources, digital tools and portfolio oversight to support high-quality, cost-effective clinical research.
Mayo Clinic has expanded its Full Facilitation Model to support trial activation and introduced activation lanes tailored to trial characteristics, patient impact and operational needs. This approach helps study teams match activation timelines to the complexity and urgency of each trial.
The Office of Clinical Trials also supports responsible portfolio management through improved oversight of studies with no participant enrollment. Standardized monitoring, notifications and review processes help study teams identify enrollment challenges earlier and make data-informed decisions about trial continuation, additional support or closure.
Improving access to clinical trials
The Office of Clinical Trials works to make clinical trials easier for patients and care teams to find, consider and join. This includes integrating clinical trials more deliberately into routine clinical practice and using digital tools to support earlier, smarter patient matching.
Current efforts include artificial intelligence-enabled trial matching, patient-facing discovery tools, clinical workflow improvements and decision-support tools that help care teams identify trial opportunities. These approaches are designed to reduce friction for clinical teams, improve enrollment and help more patients learn about relevant trials.
The team also supports decentralized clinical trial capabilities through Clinical Trials Beyond Walls. This work includes remote participant monitoring, app-based patient-reported outcomes, wearable integrations, remote biospecimen collection and home delivery of study medications when appropriate. These approaches can reduce participation burden and expand access for patients who may not be able to complete all trial activities in traditional clinical settings.
Novel and pragmatic clinical trial design
The Office of Clinical Trials supports the translation of novel clinical trial designs, including pragmatic trials embedded in real-world clinical care settings. Recent efforts include hands-on education, department-level outreach, protocol development resources and tools that help investigators understand how pragmatic trials, decentralized trials, artificial intelligence-enabled studies and digital innovation relate to one another.
Strategic fit
The office supports Mayo's mission to improve healthcare by helping clinical trials move from planning to activation, enrollment, conduct and translation. Its work strengthens the connection between research and practice by aligning operational support, clinical workflows, participant access and trial innovation.
As part of CCaTS, this work also aligns with National Center for Advancing Translational Sciences priorities by addressing barriers that slow translation, supporting generalizable solutions and improving the efficiency and effectiveness of clinical research.
Cultural fit
The Office of Clinical Trials team reflects Mayo Clinic's value of teamwork. Staff collaborate across research, clinical practice, technology, community engagement and sponsor partnerships to support high-quality trials that meet patient needs.
By integrating research more closely into clinical care, expanding digital and decentralized capabilities, and supporting innovative study designs, the team helps Mayo Clinic bring more trial opportunities to patients while strengthening the infrastructure needed for rigorous clinical research.
For questions about clinical trial support, sponsor engagement or available resources, contact us.