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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 61-70 of 122 for knee

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  1. A Study of Performance of a New Investigational Prosthesis Design and Explore How Mimicking the Human Ankle May Enhance Maneuverability of Walking

    Rochester, MN

  2. 53-Week Study Evaluating The Safety And Efficacy Of Intra-Articular Injections Of TPX-100 With Mild To Severe Tibio-Femoral Osteoarthritis Of The Knee

    Rochester, MN

  3. Severity of Chronic Knee Pain After Total Knee Replacement

    Rochester, MN

  4. A Study to Validate the PAKA (Patient Approved Knee Assessment) for Sports-Related Knee Surgery

    Rochester, MN

  5. What is the Value of a Star When Choosing a Provider for Total Joint Replacement?

  6. A Study to Evaluate Preventative Saphenous Nerve Neurectomy in Primary Total Knee Arthroplasty

    Jacksonville, FL

  7. A Study to Evaluate Meniscal Extrusion with and without Medial Knee Unloader Bracing Using Ultrasound

    Minneapolis, MN

  8. A Study to Evaluate Cardiotoxicity in Total Hip and Knee Arthroplasty

    Rochester, MN

  9. A Study to Evaluate the Incidence of Infrapatellar Branch of the Saphenous Nerve Encounters during Knee Arthroplasty

    Jacksonville, FL

  10. Highly Congruent Polyethylene and Posterior Stabilized Designs in Total Knee Arthroplasty

    Rochester, MN

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