A Study to Evaluate Preventative Saphenous Nerve Neurectomy in Primary Total Knee Arthroplasty


About this study

The purpose of this study is to evaluate the incidence of chronic knee pain at 6 months following primary total knee arthroplasty. Secondary outcomes include incidence of knee numbness, postoperative sensory loss or change at the knee, range of motion (ROM), resting pain with Visual Analog Scale (VAS), Knee Injury and Osteoarthritis Outcome Score (KOOS), quality of life measurement assessed by SF-36.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Primary unilateral total knee arthroplasty (TKA)  candidate.
  • Patients aged 18 to 90 years old.

Exclusion Criteria:

  • Body Mass Index (BMI) >40.
  • Unable to complete follow-up questionnaires.
  • Poor compliance risk.
  • Health condition deemed by physician to preclude patient’s ability to participate in the trial. 
  • Previous surgery at the knee (excluding arthroscopy).


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Glenn Shi, M.D.

Open for enrollment

Contact information:

Glenn Shi M.D.



More information


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