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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 81-90 of 123 for knee

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  1. A Study to Assess Pre- and Postoperative Serum Mast Cell Tryptase Levels in Primary TKA Patients to Determine Whether There is an Association with the Development of Post-operative Stiffness

    Rochester, MN

  2. A Study to Evaluate Whether Ultrasound Can Detect Medial Meniscal Extrusion More Frequently Than MRI?

    Minneapolis, MN

  3. A Study to Evaluate Manipulation Under Anesthesia After Bilateral Primary Total Knee Arthroplasty

    Rochester, MN

  4. A Study to Assess and Compare Regenerative Injection Therapies such as Bone Marrow Aspiration and Concentration (BMAC) and Platelet Rich Plasma (PRP) for Osteoarthritis

    Jacksonville, FL

  5. A Study to Evaluate Sex Disparities in Arthrogenic Muscle Inhibition

    Rochester, MN

  6. A Study Comparing Ultrasound versus Nerve Stimulator Guidance Used with a Nerve Block for Postoperative Knee Pain Control

    Scottsdale/Phoenix, AZ

  7. A Study Evaluating Time to Return of Lower Extremity Motor Function Following Spinal Anesthetic with Mepivacaine Versus Low-Dose Bupivacaine for Primary Total Hip and Knee Arthroplasty

    Rochester, MN

  8. A Study of Using Only One Question to Assess Outcomes After Total Hip or Knee Replacement

  9. Genetic Expression in Osteolysis, Infection, Arthrofibrosis & Metal Reactions in THA & TKA: A Microarray Analysis to Characterize Individual Host Response to the Molecular Mechanisms of Loosening and Arthrofibrosis

    Rochester, MN

  10. A Study to Establish and Validate Standard Operating Procedures for Laboratory Tests on Synovial Fluid

    Rochester, MN

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