Inclusion Criteria:

- Meets American College of Rheumatology Classification criteria for knee osteoarthritis.

Exclusion Criteria:

- Any inability to complete study procedures, including, but not limited to low English
language literacy.

- Unstable medical condition that presents as an absolute or relative contraindication
for participation (e.g., unstable angina, poorly controlled diabetes mellitus, end
stage renal failure, automated implantable cardioverter-defibrillator that cannot be
disabled before RFA).

- Severe untreated bleeding disorder (anticoagulants may be continued during phase II
treatments in most patients).

- Severe vision or hearing impairment or serious cognitive impairment that could
interfere with consent or outcome assessment.

- Poorly controlled serious psychiatric condition.

- Active substance abuse.

- Scheduled joint replacement on the affected knee.

- History of unilateral total knee arthroplasty (TKA) with complaints of KOA pain
limited to the operated knee.

- Ulcers or an open wound in the region of the index knee.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 9/21/22. Questions regarding updates should be directed to the study team contact.