Clinical Trials

Overview

About this study

The purpose of this study is to evaluate the effectiveness and safety of tramadol and oxycodone therapy in comparison to oxycodone alone as part of a multimodal pain regimen to reduce postoperative opioid consumption, pain, minimize adverse events and complications for primary total knee arthroplasty (TKA) and primary total hip arthroplasty (THA).
We hypothesize that for patients undergoing primary TKA or THA, the use of a combined tramadol and oxycodone therapy as part of a multimodal pain regimen will provide greater pain relief and less opioid consumption within 90 days after surgery without an increase in adverse events as compared to patients receiving oxycodone alone.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Participating Mayo Clinic locations

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